Resveratrol DOES provide anti-aging benefits

nutraMetrix Isotonix® Resveratrol

Courtesy of CBS.com
 
After some debate, Harvard Medical School researchers are saying they have confirmed that compound resveratrol that's found in red wine does provide anti-aging benefits.

The study, which was published on March 8 in Science, shows that resveratrol stimulates production of SIRT1, a serum that blocks diseases by speeding up the cell's energy production centers known as mitrochondria.

Researchers have also figured out which gene allows resveratrol to produce SIRT1, and believe that some drugs currently in clinical trials may be able to provide the same anti-aging benefits as well. 

"In the history of pharmaceuticals, there has never been a drug that binds to a protein to make it run faster in the way that resveratrol activates SIRT1," senior author David Sinclair, Harvard Medical School professor of genetics, said in a press release. "Almost all drugs either slow or block them."

Resveratrol is a naturally-occuring polyphenols antioxidant that is found in some plant products like grapes and cocoa. It is categorized as a phytoalexin, an antimicrobial compound that is produced by plants to protect them from rough environments like excessive ultraviolet light, infections and climate changes.

Resveratrol has been linked to protection against obesity and diabetes, a reduced risk for blood clotting and a way to lower "bad" LDL cholesterol, due to the compound's ability to dilate blood vessels, increase nitric oxide and block the stickiness of platelets. However, some research came into question when Dr. Dipak K. Das, director of the cardiovascular research center at the University of Connecticut who led several reseveratrol studies, was accused of making up results in January 2013.

There was also a controversy behind whether SIRT1's production was actually influenced by resveratrol. Earlier studies have used a man-made chemical group which glowed brighter the more SIRT1 activity went up. Without this chemical, the experiments didn't work. Some scientists believed that because of this, it meant that SIRT1's activity was only a laboratory construct and didn't exist in nature.

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"We had six years of work telling us that this was most definitely not an artifact," Sinclair, who initially published a study in 2006 linking resveratrol to SIRT1 and longevity in mice using that man-made chemical, said. "Still, we needed to figure out precisely how resveratrol works. The answer was extremely elegant." 

To prove that there was a link between resveratrol and SIRT1, scientists discovered that the man-made chemical was actually close to three amino acids that were naturally found in cells, one of which is tryptophan, the chemical thought to make people drowsy after eating turkey. Instead of using the florescent chemical, researchers used a tryptophan residue in a test tube to see if it would create more SIRT1, which it did. 

Then, Sinclair and his team looked at 2,000 mutants of the gene responsible for SIRT1 to find out how resveratrol worked, and found one mutation that stopped resveratrol's effects by swapping out one of the 747 amino acid residues. 

After they found where this mutation was found on SIRT1-creating gene and how to control it, researchers replaced the normal SIRT1 gene in manufactured muscle and skin cells with the one that stopped resveratrol's effect. They then introduced resveratrol and some other medications in clinical trials. Resveratrol and some of the medications were able to speed up mitrochondria by activating more SIRT1 in normal cells, but the mutated cells were unaffected by the substances.

"This was the killer experiment," said Sinclair. "There is no rational alternative explanation other than resveratrol directly activates SIRT1 in cells. Now that we know the exact location on SIRT1 where and how resveratrol works, we can engineer even better molecules that more precisely and effectively trigger the effects of resveratrol."
It is important to note that Sinclair is a co-founder and scientific advisor of Sirtris, a GlaxoSmithKline company. Sirtris currently has a number of sirtuin (SIRT1)-activating compounds in clinical trials.

Sinclair told the Telegraph in a separate interview that he wants to continue the studies to see if reveratrol can help people who are already really healthy. 

"Things there are also looking promising. We're finding that ageing isn't the irreversible affliction that we thought it was," he commented. "Some of us could live to 150, but we won't get there without more research."

Many agree that the information is promising.

"This is not weak evidence at this point," Leonard Guarente, a biologist at the Massachusetts Institute of Technology and a Sirtris scientific advisory board member, added to the Los Angeles Times."You would really bet the ranch on this one." 

"It might bring together the different views so we can move forward," Brian Kennedy, president and chief executive of the Buck Institute for Research on Aging in Novato, Calif., added in a press release. Kennedy previously questioned the results of studies using resveratrol and yeast. "This is how science works."

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Click HERE to purchase nutraMetrix Isotonix® Resveratrol

Primary Benefits of nutraMetrix Isotonix® Resveratrol*:

• Maintains cell health
• Promotes normal cell cycle activity
• Promotes apoptosis (programmed cell death) in unhealthy cells
• Promotes normal nuclear factor kappa B (NF-Kappa B – protein) and cyclooxygenase-2 (COX-2 - enzyme) activity
• Promotes normal activity of the SIRT-1 gene (involved in calorie restriction, fat mobilization, mitochondrial function)
• Promotes cardiovascular health (promotes normal platelet activity, helps maintain normal vasorelaxation, provides antioxidant protection of LDL particles).
• Superior antioxidant and high ORAC value
• Promotes a healthy prostate gland
• Helps promote apoptosis in unhealthy prostate cells

Key Ingredients Found In nutraMetrix® Isotonix® Resveratrol:

Resveravine® (20% resveratrol extract): 10 mg

Resveratrol is a natural antioxidant found in red wine. Resveravine is a natural extract from Vitis vinifera standardized to contain 20% oligostilbenes. Resveravine is 100 to 300 times more concentrated in trans-resveratrol than other products made from grape skin. It provides antioxidant protection of low-density lipoprotein (LDL) particles, promotes normal platelet activity, vasorelaxation and blood flow, all which support cardiovascular health. It has been shown to promote apoptosis (programmed cell death) in unhealthy cells. Another proposed mechanism of action involves the study of the SIRT-1 gene (also known as the longevity gene). Sirtuins, known as Silent Information Regulators (SIRs), are deacetylase enzymes identified in all living creatures. Sirtuin proteins are known to play an important role in keeping regions of chromosomes turned off. Sirtuin controls the enzyme that converts acetate, a source of calories, into acetyl-CoA, a key component of cellular respiration. In humans, there are seven different sirtuins, SIRT-1 to SIRT-7. SIRT-1 has been studied by scientist for its potential effect on human cell lifespan.*

Resveratrol promotes normal activity of SIRT-1. Studies have shown that SIRT-1 activates a critical component of calorie restriction in mammals and promotes fat mobilization. The most recent study (Nature 2006) demonstrated that obese mice fed red wine extract (resveratrol) were in better health and lived longer than obese mice that were not fed the red wine extract. The resveratrol group were more able to maintain heart health compared to mice that were not fed resveratrol. SIRT-1 activation also supports healthy mitochondrial function and supports energy expenditure. Resveratrol has also been shown to have phytoestrogen activity and may support optimal estradiol activity. Other studies have documented neuroprotective benefits associated with resveratrol supplementation.*

A comparison test was made to evaluate the activating effect on human SIRT-1 of Resveravine and pure trans-resveratrol. Only the trans-resveratrol form of the molecule promotes normal activation of the mammalian SIRT-1 gene in vitro test. Resveravine was more than eight times more likely to promote SIRT-1 activity than pure trans-resveratrol, showing that Resveravine is more efficient than resveratrol in promoting the normal activity of SIRT-1. Therefore, while the specific mechanisms of SIRT-1 and resveratrol are still unclear, the studies show that SIRT-1 is essential in lifespan extension and health improvement, and resveratrol promotes SIRT-1 activity.*

Studies in numerous species have demonstrated that reduction of calories 30 to 50 percent below ad libitium levels of a nutritious diet can promote a longer lifespan, improve overall health, promote normal stress resistance and decelerate functional decline. Studies showed that, SIRT-1 activates a critical component of calorie restriction in mammals, and promotes fat mobilization in adipocytes by repressing PPAR (test conducted on mice). Because healthy fat levels have been shown to promote a longer murine lifespan, it is suggested that calorie restriction could be connected to SIRT-1 and life extension in mammals.

As an alternative strategy, new research has focused on the development of calorie restriction mimetics, compounds that mimic the effect of calorie restriction by targeting metabolic and stress response pathways affected by calorie restriction, but without restricting caloric intake. Resveratrol has been suggested as a potential calorie restriction mimetic.  

Supplementing mice with resveratrol significantly increases their aerobic capacity. By promoting healthy SIRT-1 activity, resveratrol promotes healthy mitochondrial function and supports energy expenditure, thereby promoting healthy weight. In vivo test conducted on mice on a high-calorie diet, resveratrol shifts the physiology of middle-aged mice on a high-calorie diet towards that of mice on a standard diet and promotes their overall health.  

BioVin® Advanced (French Red Wine Extract with 5% resveratrol): 200 mg

Red wine extract containing oligomeric proanthocyanins (OPCs), known to be extremely effective in supporting cardiovascular health by supporting normal blood circulation, strengthening blood vessels, and promoting normal platelet activity. BioVin Advanced provides OPCs and additional Resveratrol. The red wine grape contains two main constituents shown to be of significant antioxidant value: red wine polyphenols (flavonoids) and trans-resveratrol (mentioned above). Oligomeric proanthocyanins are flavonoid complexes that act as super potent antioxidants in the human body. BioVin Advanced combines the antioxidant properties of OPCs with trans-resveratrol to promote phase 2 metabolizing enzymes, which are involved in the detoxification of the body’s cells, promoting apoptosis (programmed cell death) in unhealthy cells, promoting healthy cholesterol levels, and general free-radical scavenging properties.*

VitaBlue® Wild Blueberry Extract (12.5% anthocyanins): 50 mg

Blueberries rank highest among many fruits and vegetables for ORAC activity and contain 25-30 different types of anthocyanins. Anthocyanin gives blueberries (and other fruits) their rich blue and red coloring, and is a powerful flavonoid antioxidant. The mechanism of action surrounding anthocyanins has been studied at the molecular level, demonstrating effects such as the promotion of healthy cells and apoptosis (programmed cell death). Blueberries provide large amounts of chlorogenic acid, which is thought to be important in promoting cellular health. VitaBlue Wild Blueberry Extract supports the body’s COX-2 inhibitors and provides powerful antioxidants in much higher quantities than fresh blueberries, and show to be effective in promoting cardiovascular health, contributing to normal cell cycle traverse, and maintaining overall cellular health.*

 

What Makes nutraMetrix® Isotonix® Resveratrol Unique?

Poor cellular and cardiovascular health is becoming a worldwide epidemic. An unhealthy diet of processed, high-calorie, high-fat foods, pollution, smoking, and sedentary lifestyles all contribute to poor cell and heart health. Scientists revealed The French Paradox, which states that even though the French drink, smoke and eat high-fat foods, they have some of the lowest incidences of poor cardiovascular and cellular health. Scientists attribute this to the large amounts of red wine that the French consume or, more importantly, an extract found in red wine: resveratrol. Resveratrol is an ingredient with incredible clinical research, revealing it supports cardiovascular and normal cell health. Because wine is so highly processed, the actual amount of resveratrol is quite low. One would have to drink at least three bottles of red wine a day to experience the effects of resveratrol extract. Additionally, the content of resveratrol in red wine is inconsistent and varies by type of wine, region and processing techniques. Resveratrol extract or more specifically, Resveravine®, which is a more concentrated form of resveratrol, ensures that the body reaps all of the benefits of resveratrol, without the ill effects from three bottles of wine.*

Isotonix Resveratrol is an isotonic-capable supplement made from three patented ingredients: Resveravine with 20% resveratrol extract, BioVin® Advanced with 5% resveratrol extract, and VitaBlue® (wild blueberry extract), designed to promote normal cell health. Isotonix Resveratrol works to maintain cell health, promote normal cell cycle activity, promote apoptosis (programmed cell death) in unhealthy cells, support the normal activity of the SIRT-1 gene, and promote cardiovascular health by promoting healthy platelet activity, promoting vasorelaxation, and providing antioxidant protection of LDL particles. Resveravine is a combination of trans-resveratrol (20% purity) and viniferin extracted from vine stems, which work synergistically to enhance the effectiveness of resveratrol extract. Trans-resveratrol is the predominate isomer found in red wine grapes and juice, and Resveravine is 100 to 300 times more concentrated in trans-resveratrol than other products from grape skin. According to the Linus Pauling Institute at Oregon State University, trans-resveratrol may have a higher bioavailability than other isomers of resveratrol. Resveravine provides a higher level of free radical defense against oxidative stress, stronger promotion of normal cellular activity and higher antioxidant protection of LDL particles than pure resveratrol extract.*

Studies of numerous species have shown that a reduction in calories has been linked to a longer lifespan. The SIRT-1 gene activates a critical component of calorie restriction in mammals and promotes fat metabolization. There is evidence that resveratrol may be a calorie restriction mimetic, a compound that mimics the effects of calorie restriction by targeting metabolic and stress response pathways affected by calorie restriction, but without restricting caloric intake, which may be helpful in promoting a longer lifespan. By promoting healthy SIRT-1 activity, resveratrol promotes healthy mitochondrial function and supports energy expenditure, thereby promoting a healthy weight.*

Isotonic, which means “same pressure,” bears the same chemical resemblance of the body’s blood, plasma and tears. All fluids in the body have a certain concentration, referred to as osmotic pressure. The body’s common osmotic pressure, which is isotonic, allows a consistent maintenance of body tissues. In order for a substance to be absorbed and used in the body’s metabolism, it must be in an isotonic state. 

Isotonic dietary supplements are delivered in an isotonic solution. This means that the body has less work to do to obtain maximum absorption of the nutrients. The isotonic state of the suspension allows nutrients to pass directly into the small intestine and rapidly absorb into the bloodstream. With Isotonic capable products, little nutritive value is lost, making the absorption of nutrients highly efficient while delivering maximum results.

Frequently Asked Questions About nutraMetrix® Isotonix® Resveratrol:

Resveratrol contains wine extracts. Is it alcohol free?

Yes. Resveratrol is alcohol free; there is no alcohol in this product.*

I am currently taking medication to manage my cholesterol. Can I still take Resveratrol?

There are no documented interactions with cholesterol medication and any of the ingredients in Resveratrol. However, before taking any natural supplement, you should consult your physician.

Are there any contraindications for Isotonic Resveratrol?

Yes. If you are currently taking warfarin (Coumadin) or other anti-platelet/anti-coagulant, you should not take this product. If you are taking any other prescription drugs or have an ongoing medical condition, you should consult your physician before using this product. Women who are pregnant or nursing should not take this product.*

Can I take Resveratrol and still have a glass of wine with dinner?

Yes. There is no cause of concern.*

         

I already take a multivitamin. Why do I need Resveratrol?

Resveratrol is not a multivitamin. It is a product designed to promote optimal cell health and provide cardiovascular support.*

If I am an alcoholic, can I still take Resveratrol even though it is from red wine?

Yes. Isotonix Resveratrol does not contain alcohol. Resveratrol is an extract from grape skins and vines that are used to make red wine.*

Will I get drunk from taking Resveratrol?

No. Isotonix Resveratrol does not contain alcohol.

Is this product vegetarian friendly?

Yes. Isotonix Resveratrol is a vegetarian product.

Who should take this product?

Clinical studies have shown that resveratrol extract may be helpful in promoting apoptosis (programmed cell death) in unhealthy cells, supporting normal cell cycle activity, promoting the normal activity of the SIRT-1 gene, thereby supporting overall cellular health. If you are interested in promoting cellular health and maintaining good cardiovascular health, then Isotonix Resveratrol is perfect for you.*

Can men and women take this product?

Yes. However, women with a history of estrogen-sensitive cancers (breast, ovarian, uterine) should not take this product. Women who are pregnant or nursing should not take this product.*

When should I start to see/feel the effects of this product?  What should I expect?

The antioxidant benefits of Isotonix Resveratrol should be noticeable in about four to six weeks. Please remember that everyone’s body is different, so for some it may take longer to notice the benefits of Resveratrol. You should expect to feel better and healthier overall.*

Do I need OPC-3 if I take this product?

Isotonix OPC-3 is a superior antioxidant with many health benefits. Isotonix Resveratrol can be taken with other antioxidants; in fact, antioxidants work in several mechanisms, and they build upon each other. For a complete, comprehensive antioxidant defense, taking OPC-3 and Resveratrol is a smart choice to protect your body from the damaging effects of free radicals.*

* These statements have not been evaluated by the Food and Drug Administration.
This product(s) is not intended to diagnose, treat, cure or prevent any disease.

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