Can't Get To The Gym? Have A Glass of Red Wine

Thursday, June 28th 2012 at 7:00 pm by Margie King, Health Coach (Courtesy of GreenMedInfo.com)

It may sound like a dream come true for many of us, but a research study published in the FASEB Journal,  suggests that resveratrol, the healthy compound found in red wine, could help counter the negative effects of being a couch potato.

The study tested the effects of resveratrol on rats under conditions resulting from spaceflight and sedentary lifestyles, and may tell researchers something about the same effects on people.  The report describes rat experiments that simulated the weightlessness of spaceflight. Some rats were fed resveratrol and others were not. The group fed resveratrol did not develop insulin resistance, muscle loss, or loss of bone mineral density, as did those who were not fed resveratrol.

Resveratrol has often been cited as the secret to the French Paradox - the fact that French people enjoy low levels of cardiovascular disease, even though their diets are rich in saturated fats and oils. Some researchers think the reason for this so-called paradox lies in France's love of red wine, which is the most important dietary source of resveratrol.  Other sources include grapes, raspberries, mulberries, blueberries, cranberries and surprisingly, peanuts.

According to Gerald Weissmann, M.D., Editor-in-Chief of the FASEB Journal, "There are overwhelming data showing that the human body needs physical activity, but for some of us, getting that activity isn't easy. A low gravity environment makes it nearly impossible for astronauts. For the earthbound, barriers to physical activity are equally challenging, whether they be disease, injury, or a desk job. Resveratrol may not be a substitute for exercise, but it could slow deterioration until someone can get moving again."
Scientists studied rats that underwent simulated weightlessness and were given a daily dose of resveratrol. The control group showed decreased muscle mass and strength, development of insulin resistance, loss of bone mineral density and lower resistance to breakage. The group receiving resveratrol showed none of these complications.

According to the researchers their study suggests that resveratrol may be able to prevent the harmful consequences of sedentary behaviors in humans.

Resveratrol is a polyphenol and acts as a powerful antioxidant suppressing "free radicals" which can cause cell damage. Various clinical trials have indicated that it may have anti-aging properties and prevent the growth of some cancers in mice, inhibit enzymes that cause inflammation, shrink tumors and increase blood flow, thus reducing cardiovascular diseases. In many cases, it has also been shown to extend the life of obese animals and help to regulate insulin sensitivity.  In fact, all good reasons to enjoy a glass of red wine.

****

 Learn more about Isotonix® Resveratrol

Key Ingredients Found In Isotonix® Resveratrol:

Resveravine® (20% resveratrol extract): 10 mg

Resveratrol is a natural antioxidant found in red wine. Resveravine is a natural extract from Vitis vinifera standardized to contain 20% oligostilbenes. Resveravine is 100 to 300 times more concentrated in trans-resveratrol than other products made from grape skin. It provides antioxidant protection of low-density lipoprotein (LDL) particles, promotes normal platelet activity, vasorelaxation and blood flow, all which support cardiovascular health. It has been shown to promote apoptosis (programmed cell death) in unhealthy cells. Another proposed mechanism of action involves the study of the SIRT-1 gene (also known at the longevity gene). Sirtuins, known as Silent Information Regulators (SIRs), are deacetylase enzymes identified in all living creatures. Sirtuin proteins are known to play an important role in keeping regions of chromosomes turned off. Sirtuin controls the enzyme that converts acetate, a source of calories, into acetyl-CoA, a key component of cellular respiration. In humans, there are seven different sirtuins, SIRT-1 to SIRT-7. SIRT-1 has been studied by scientist for its potential effect on human cell lifespan.*

Resveratrol promotes normal activity of SIRT-1. Studies have shown that SIRT-1 activates a critical component of calorie restriction in mammals and promotes fat mobilization. The most recent study (Nature 2006) demonstrated that obese mice fed red wine extract (resveratrol) were in better health and lived longer than obese mice that were not fed the red wine extract. The resveratrol group, were more able to maintain heart health compared to mice that were not fed resveratrol. SIRT-1 activation also supports healthy mitochondrial function and supports energy expenditure. Resveratrol has also been shown to have phytoestrogen activity and may support optimal estradiol activity. Other studies have documented neuroprotective benefits associated with resveratrol supplementation.*

A comparison test was made to evaluate the activating effect on human SIRT-1 of Resveravine and pure trans-resveratrol. Only the trans-resveratrol form of the molecule promotes normal activation of the mammalian SIRT-1 gene in vitro test. Resveravine was more than eight times more likely to promote SIRT-1 activity than pure trans-resveratrol, showing that Resveravine is more efficient than resveratrol in promoting the normal activity of SIRT-1. Therefore, while the specific mechanisms of SIRT-1 and resveratrol are still unclear, the studies show that SIRT-1 is essential in lifespan extension and health improvement, and resveratrol promotes SIRT-1 activity.*

Studies in numerous species have demonstrated that reduction of calories 30 to 50 percent below ad libitium levels of a nutritious diet can promote a longer lifespan, improve overall health, promote normal stress resistance and decelerate functional decline. Studies showed that, SIRT-1 activates a critical component of calorie restriction in mammals, and promotes fat mobilization in adipocytes by repressing PPAR (test conducted on mice). Because healthy fat levels have been show to promote a longer murine lifespan, it is suggested that calorie restriction could be connected to SIRT-1 and life extension in mammals.

As an alternative strategy, new research has focused on the development of calorie restriction mimetics, compounds that mimic the effect of calorie restriction by targeting metabolic and stress response pathways affected by calorie restriction, but without restricting caloric intake. Resveratrol has been suggested as a potential calorie restriction mimetic.  

Supplementing mice with resveratrol significantly increases their aerobic capacity. By promoting healthy SIRT-1 activity, resveratrol promotes healthy mitochondrial function and supports energy expenditure, thereby promoting healthy weight. In vivo test conducted on mice on a high-calorie diet, resveratrol shifts the physiology of middle-aged mice on a high-calorie diet towards that of mice on a standard diet and promotes their overall health.  

BioVin® Advanced (French Red Wine Extract with 5% resveratrol): 200 mg

Red wine extract containing oligomeric proanthocyanins (OPCs), known to be extremely effective in supporting cardiovascular health by supporting normal blood circulation, strengthening blood vessels, and promoting normal platelet activity. BioVin Advanced provides OPCs and additional Resveratrol. The red wine grape contains two main constituents shown to be of significant antioxidant value: red wine polyphenols (flavonoids) and trans-resveratrol (mentioned above). Oligomeric proanthocyanins are flavonoid complexes that act as super potent antioxidants in the human body. BioVin Advanced combines the antioxidant properties of OPCs with trans-resveratrol to promote phase 2 metabolizing enzymes, which are involved in the detoxification of the body’s cells, promoting apoptosis (programmed cell death) in unhealthy cells, promoting healthy cholesterol levels, and general free-radical scavenging properties.*

VitaBlue® Wild Blueberry Extract (12.5% anthocyanins): 50 mg

Blueberries rank highest among many fruits and vegetables for ORAC activity and contain 25-30 different types of anthocyanins. Anthocyanin gives blueberries (and other fruits) their rich blue and red coloring, and is a powerful flavonoid antioxidant. The mechanism of action surrounding anthocyanins has been studied at the molecular level, demonstrating effects such as the promotion of healthy cells and apoptosis (programmed cell death). Blueberries provide large amounts of chlorogenic acid, which is thought to be important in promoting cellular health. VitaBlue Wild Blueberry Extract supports the body’s COX-2 inhibitors and provides powerful antioxidants in much higher quantities than fresh blueberries, and show to be effective in promoting cardiovascular health, contributing to normal cell cycle traverse, and maintaining overall cellular health.*

Astaxanthin: A Rising Star in Alzheimer's Prevention

Courtesy ofMercola.com

By Dr. Mercola
In the United States, someone develops Alzheimer's disease every 69 seconds, and by 2050 this is expected to increase to a new case every 33 seconds, according to the Alzheimer's Association's 2011 Alzheimer's Disease Facts and Figures.
The disease is currently at epidemic proportions, with 5.4 million Americans—including one in eight people aged 65 and over—living with Alzheimer's disease.
By 2050, this is expected to jump to 16 million, and in the next 20 years it is projected that Alzheimer's will affect one in four Americans. If that comes to pass, it would then be more prevalent than obesity and diabetes is today!
Alzheimer's is a sad, devastating disease that develops slowly and gets worse over time. Worse yet, there is no known cure and very few treatments. Alzheimer's drugs are often of little to no benefit at all, which underscores the importance of prevention throughout your lifetime.
Alzheimer's develops over the course of a few decades, so the time to start preventing it is yesterday. Your approach to preventing this terrible disease should be a comprehensive lifestyle approach.
I will be discussing the most important aspects of this in a moment, but first, I would like to share new findings about one particular nutritional supplement that has scientists very excited in the battle against Alzheimer's disease.

Astaxanthin is a Rising Star in Alzheimer's Prevention

Astaxanthin is a natural pigment with unique properties and many clinical benefits, including some of the most potent antioxidant activity currently known. It is the same pigment that makes flamingos pink.
These birds are born with grey feathers—and after consuming their natural diet of astaxanthin-containing algae and crustaceans, they turn pink! It has been found to reduce the accumulation of phospholipid hydroperoxidases (PLOOH)—compounds known to accumulate in the red blood cells of people who suffer from dementia—and scientists now believe astaxanthin could help prevent dementia, including Alzheimer's.
As a fat-soluble nutrient, astaxanthin readily crosses your blood-brain barrier. One studyⁱⁱ found it may help prevent neurodegeneration associated with oxidative stress, as well as make a potent natural "brain food."
The molecules of astaxanthin neutralize free radicals and other oxidants without being destroyed or becoming pro-oxidants themselves in the process. It's is a unique molecule whose shape allows it to precisely fit into a cell membrane and span its entire width. In this position, astaxanthin can intercept potentially damaging moleculesbefore they can damage your cells.
In fact, astaxanthin is hundreds of times more effective than vitamin E in squelching singlet oxygen free radicals, and far exceeds the free radical scavenging power of vitamin C, CoQ10, beta-carotene, and green tea. According to a recent article in the Alternative Medicine Review:

"Astaxanthin improved cognition in a small clinical trial and boosted proliferation and differentiation of cultured nerve stem cells…   Astaxanthin's clinical success extends beyond protection against oxidative stress and inflammation, to demonstrable promise for slowing age-related functional decline."

This supports the findings of a prior 2011 study in the British Journal of Nutrition that showed taking 6 mg or 12 mg of astaxanthin daily for 12 weeks lowered levels of PLOOH by 40 percent and 50 percent, respectively.
It is unlikely you will be able to obtain enough astaxanthin from diet alone… unless you are a flamingo. You can get some astaxanthin by taking krill oil, which is a fantastic omega-3 fat supplement. But you can boost your astaxanthin even MORE by adding a pure astaxanthin supplement to your nutritional regimen.  For optimal absorption, make sure to take krill oil and/or astaxanthin with a fat-containing meal, since both are fat-soluble.

"Senior Moments" are NOT a Normal Part of Aging

In spite of how common memory loss is among Westerners, it is NOT a "normal" part of aging. Research has shown that even mild "senior moments" are caused by the same brain lesions associated with Alzheimer's disease and other forms of dementia. These cognitive changes are by no means inevitable! People who experience very little decline in their cognitive function up until their deaths have been found (post-mortem) to be free of brain lesions, showing that it's entirely possible to prevent the damage from occurring in the first place.

What Causes Alzheimer's Disease?

In order to effectively prevent a disease, you must address its underlying causative factors. Although we do not have definitive "proof" of what, specifically, causes Alzheimer's, a number of factors have been linked to an increased risk of dementia, and we know enough about those to in turn make educated recommendations for preventing this type of brain deterioration.
The more risk factors you have, the higher your changes are for developing dementia. You may already know I have become passionate about warning of the dangers of fructose. There is NO question in my mind that regularly consuming more than 25 grams of fructose per day will increase your risk of losing your mind.Fructose will catalyze the impact of virtually every other risk factor, like exposure to toxins such as aluminum, or mercury, or even genetic predispositions. It does this by impairing your body's normal self-repair capacity and its ability to recover from these types of assaults.
Following are a number of other factors associated with an increased risk of Alzheimer's disease. Please note that the first four are related to fructose intake.
Health conditions and drug therapies

• Obesity, especially increased belly fat, insulin resistance, and diabetes: diabetics have up to 65 percent higher risk of developing Alzheimer's disease. Keep your fasting insulin level below 3 by minimizing sugar and grains and exercising regularly.
• Elevated uric acid levels: fructose is one of the primary factors that drives up uric acid, which is another reason to avoid excess sugar.
• High blood pressure.
• Heart disease and atrial fibrillation^iv: If you have "atrial fib," you are 44 percent more likely to develop dementia.
• Thyroid dysfunction.^v
• Head trauma^vi: There appears to be a "strong link" between a history of head trauma and Alzheimer's disease, especially if the trauma occurred repeatedly or involved loss of consciousness—so keep your seat belt fastened.
• Anticholinergic drugs: Drugs that block acetylcholine, a nervous system neurotransmitter, have been shown to increase your risk of dementia. These drugs include certain nighttime pain relievers, antihistamines, sleep aids, certain antidepressants, medications to control incontinence, and certain narcotic pain relievers.
One study found that those who took drugs classified as "definite anticholinergics" had a four times higher incidence of cognitive impairment. Regularly taking two of these drugs further increased the risk.

Nutritional deficiencies

• Vitamin D deficiency: In 2007 researchers at the University of Wisconsin uncovered strong links between low levels of vitamin D in Alzheimer's patients and poor outcomes on cognitive tests. Vitamin D may enhance the levels of important chemicals in your brain that protect your brain cells and combat the brain inflammation seen in dementia patients.
  A 2011 study at UCLA found the combination of vitamin D3 and curcumin (the pigment that makes turmeric yellow) to be a highly beneficial combination for Alzheimer's patients.Vitamin D can also fight depression, which is experienced frequently by people with dementia.
  
  
• Vitamin B deficiencies: Elevated homocysteine levels due to vitamin B6, B12 and folate deficiencies; according to a small Finnish study recently published in the Journal Neurology, people who consume foods rich in B12 may reduce their risk of Alzheimer's in their later years.
• Insufficient omega-3 fats: High intake of the omega-3 fatty acid DHA lowers your risk for Alzheimer's by preventing the associated cell damage. Researchers also report that DHA "dramatically reduces the impact of the Alzheimer's gene."
• Vitamin E deficiency: A 2008 study showed that Alzheimer's patients who took 2,000 IU of vitamin E daily showed a 26 percent lower mortality rate.

Environmental toxins

• Aluminum toxicity: avoid antiperspirants, non-stick cookware, and vaccines containing aluminum (and mercury) adjuvants/additives, such as the flu vaccine
• Mercury toxicity: Avoid fish and seafood, which is usually contaminated with mercury, and avoid dental amalgams, which are probably the largest sources of mercury; implement the mercury detox protocol and utilize a biological dentist if you have dental amalgams
• Fluoride toxicity: More than 23 different studies indicate even moderate fluoride exposure may have damaging effects on your brain
• Copper toxicity: Evidence exists that copper can leach out of copper pipes and into tap water, and when consumed over time, can build up in your body. Copper toxicity has been linked to Alzheimer's disease, heart disease, and diabetes. You should also avoid vitamin/mineral pills that contain copper and iron, especially if you're over the age of 50
• Cell phone radiation. Radiation from cell phones and mobile phone handsets may damage areas of your brain associated with learning, memory and movement, and may trigger Alzheimer's disease

Exercise Your Body, Exercise Your Brain

Clearly, the BEST way to "treat" Alzheimer's is to lead a lifestyle that will prevent it in the first place. John J. Ratey, a psychiatrist who wrote the book Spark: The Revolutionary New Science of Exercise and the Brain, says there is overwhelming evidence that regular exercise helps fight dementia and improves mental acuity. Physical exercise may also protect against mild cognitive impairment by:

• Promoting production of nerve-protecting compounds
• Increasing blood flow to your brain
• Improving development and survival of neurons
• Promoting essential cell and tissue repair mechanisms, including growth of new brain cells
• Decreasing your risk of heart and blood vessel diseases that can impact brain function

In essence, exercise encourages your brain to work at optimum capacity by causing your nerve cells to multiply, strengthening their interconnections, and protecting them from damage. Exercising your mind daily is as important as exercising your body, so be sure to incorporate some mentally challenging activities into your life, such as playing an instrument, doing puzzles, reading, or other similar activities.

Natural Treatments for Your Anti-Alzheimer's Arsenal

Finally, there are a few other nutritional recommendations worth noting for their specific benefits in preventing and treating dementia. So, although your fundamental strategy for preventing dementia should involve a comprehensive lifestyle approach, you may want to consider adding a few of these natural dietary agents to your anti-Alzheimer's arsenal.
The three natural foods/supplements that have good science behind them, in terms of preventing age-related cognitive changes, are coconut oil, Gingko biloba, and alpha lipoic acid.

1. Coconut Oil: The primary fuel your brain needs for energy is glucose. However, your brain is able to run on more than a single type of fuel, one being ketones (ketone bodies), or ketoacids. Ketones are what your body produces when it converts fat (as opposed to glucose) into energy.
The medium chain triglycerides (MCT) found in coconut oil are GREAT source of ketone bodies, because coconut oil is about 66 percent MCTs.In fact, ketones appear to be the preferred source of brain food in patients affected by diabetes or Alzheimer's.

2. Gingko biloba: Many scientific studies have found that Ginkgo biloba has positive effects for dementia. Gingko, which is derived from a tree native to Asia, has long been used medicinally in China and other countries. Fifteen years ago, in one of the first issues of my newsletter, I posted the results of a 1997 study from JAMA^x that showed clear evidence that Ginkgo improves cognitive performance and social functioning for those suffering from dementia. Research since then has been equally promising.
   One study in 2006 found Gingko as effective as the dementia drug Aricept (donepezil) for treating mild to moderate Alzheimer's type dementia. A 2010 meta-analysis^xi found Gingko biloba to be effective for a variety of types of dementia.
   
3. Alpha lipoic acid (ALA): ALA can stabilize cognitive functions among Alzheimer's patients and may slow the progression of the disease.