Your Genes Are Not Your Destiny!

Courtesy of GreenMedInfo.com *Written By: Annemarie Colbin, Ph.D.

 

 

How living things get to be what they are is a question that has occupied philosophers and scientists for a very long time.  In the past two or three hundred years, the focus has been on what Gregor Mendel has called units of heredity, or the physical elements that are transmitted from parents to offspring.  These are now called genes, and have become an integral part of the conversation about human beings and their health.

What genes are

The cells of living beings contain chromosomes, which are recognized as the bearers of inheritable information.  Chromosomes contain a double helix of DNA (deoxyribonucleic acid) and protein.  DNA  is a long series of units called nucleotides.  It is believed that DNA makes RNA (ribonucleic acid), which differs from DNA in chemical composition.  RNA translates the information coded in the DNA and prompts the specific development of various proteins in the body. 

Genes are stretches of DNA on the chromosome, and they may be thousands of nucleotide units in length.  Gene splicing, or genetic engineering, consists of snipping one (or more) genes out of the DNA of one organism and splicing it into the DNA of another organism, much like film or sound tapes are spliced to re-arrange the sequence of images or sound.

What genes do

Individual genes provide codes for the many thousands of proteins, including enzymes, that are found in the human body.  The theory called the central dogma of molecular biology is as follows: DNA makes RNA makes protein in a one-way, irreversible sequence, and no reverse feedback is possible -- that is, the environment cannot influence the DNA, and acquired characteristics are not heritable.21(p104) The genotype is the total inheritable genetic line of a class of organism (e.g., A sheep), while the phenotype is the individual expression of those genes in a single organism (e.g., a particular lamb).

The chromosome theory of inheritance includes the following:
The collection of chromosomes in the fertilized egg constitutes the complete set of instructions for determining the timing and details of the formation of all the organs and tissues
DNA is self-replicating
DNA does not adapt to environmental stimuli
DNA is the generator of the structure that emerges from the fertilized egg in sexual reproduction.

The reductionism of genetics was firmly established with the work of Richard Dawkins, whose concept of the selfish gene proposed that organisms are nothing but the way in which genes reproduce.

What they don't do

Brian Goodwin, a British biologist and author of How the Leopard Changed its Spots: The Evolution of Complexity, is one of a number of scientists less than enamored with the gene/chromosome theory of inheritance.  I will paraphrase his objections to the list enumerated in the previous section.

This proposition is incorrect.  Genetic instructions, which create proteins, are insufficient to explain the processes that lead to the various organ formations such as those of the heart, nervous system, or limbs.  Genes are not sufficient to explain the morphology of the organism.
DNA is not an independent replicator; it can only replicate accurately within the context of the cell in which it resides.  That is, it needs a supportive environment, including an energy source and enzymes to help in the replication process.   This means that the whole unit reproduces, not the DNA by itself.
There is ample evidence that yeasts and bacteria can change their DNA in response to environmental information.
DNA stabilizes the morphology of the organism, but does not generate it by itself.
In addition, while a particular gene defect might be associated with a particular disease, it cannot predict if, when, and how that disease will manifest itself. 

Genetic engineering, which is the splicing of genes from one organism into the germ cells of another, for all its magical promises, is a literal Pandora Box.   There are serious concerns about the irreversible effect that genetically modified organisms such as corn and soy might have on the ecosystem and its life forms, because these changes in genetic material are inheritable as well as laterally, (or horizontally) transmissible via pollen, insects, and wind-borne DNA particles.

Cloning, a procedure that allows the development of new individuals from individual cells of adult animals, instead of by normal egg and sperm union, theoretically should produce animals identical to the parent donor of the cells; however, many cloned embryos die before birth and the survivors often have growth abnormalities such as breathing difficulties, heart problems, and gross overweight.

Genetics is quickly becoming the new religion, and proposes to explain everything from breast cancer to personality trains as stemming from the simple action of genes.  There is a danger here.  As Ruth Hubbard and Elijah Wald argue in Exploding the Gene Myth: How genetic information is produced and manipulated by scientists, physicians, employers, insurance companies, educators, and law enforcers, The myth of the all-powerful gene is based on flawed science that discounts the environmental context in which we and our genes exist.  It has many dangers, as it can lead to genetic discrimination and hazardous medical manipulations.     
Bruce Lipton, Ph.D., a former cell biologist and professor, in his book The Biology of Belief:  Unleashing the Power of Consciousness, Matter and Miracles (Hay House:  2005), clearly shows that genes are totally at the mercy of their environment – having a gene related to a disease does not in the least predict that one will get such a disease.  (By the way, everyone should read this book about mind-body medicine!)  This new understanding about the important influence of the environment is called "epigenetics."

According to the Wall Street Journal (1/ 9/2010), the progression of coronary heart disease, diabetes, hypertension, prostate cancer, obesity, and other chronic conditions have been reversed with integrative medicine approaches such as plant-based diets, yoga, meditation and psychosocial support.  These approaches may change the expression of hundreds of genes in only a few months. Genes associated with cancer, heart disease and inflammation were downregulated  ("turned off") whereas protective genes were upregulated ("turned on.") Even drugs have not been shown to do this.

Genes and nutrition

The Central Dogma would assume that genes will always provide the same information and express the same proteins.  Interestingly, several environmental factors may limit or change the expression of genetic information, notably aging and dietary manipulations.  There was an experiment done with "agouti" mice, which have a genetic abnormality that makes them yellow, fat, and diabetic from birth.  But when "agouti" mothers were given a nutritionally enriched diet, their children turned out with the normal brown coat, thin, and healthy.  Interestingly, the healthy offspring still had the "agouti" gene, they just didn't express it.

This experiment seems to show that nutrition can indeed influence genetic expression, for illness as well as for health.  In other words:  FOOD OVERRIDES GENETICS!  Keep that in mind when you are contemplating the difficulties of healthy eating. 

 ********* 

Would you like to "read" YOUR genetic code?

 

When it comes to our bodies, we want to make choices that have a positive impact on our health. But some of those decisions – eating the wrong foods, making certain lifestyle choices, even the way we exercise – could impact our body's ability to maintain optimum health. Even if we think we’re making the right choices, there are other factors that help determine our overall picture of health.

Genetics play a huge role in how our bodies process nutrients, how they respond to activity and how we react to our environment and surroundings. When it comes to your health, the answers are in your genes. Your DNA tells a story: how you process foods, how you react to exercise, how your environment affects your body, how your family history plays a part in your health.
What if you could learn about your health with a simple test, one that could give you realistic and reasonable recommendations to promote your quality of life? It’s time to make informed decisions about your health – no more guesswork, just facts.

The Gene SNP DNA Analysis combines your individual diet, lifestyle and environment information and is scientifically merged with your genetic background to provide an exclusive Health Action Plan designed specifically for you. It will help provide practical suggestions intended to promote your health and wellness. Based on variations in your DNA and lifestyle factors, the Gene SNP DNA Analysis will make recommendations based on how your body metabolizes food, utilizes nutrients, removes toxins and responds to physical activity. By understanding how your genetic profile affects your well-being, the Gene SNP DNA Analysis will help you take charge of optimizing your wellness. The Gene SNP DNA Analysis examines a wide variety of genes and SNPs, providing a customized Health Action plan that focuses on diet, nutrition, exercise and supplementation based on your genetic profile.    

Now you can be sure your personalized Health Action Plan includes the best possible supplementation thanks to the integration of the most advanced nutraceutical products available, Isotonix. Each product has been carefully chosen to provide you with the best supplementation based on your individualized Health Action Plan. By integrating the Gene SNP DNA Analysis with the Isotonix product line, you’ll be receiving the very best supplementation support to maintain the healthiest of lifestyles.

No longer will you have to accept a “one-size-fits-all” vitamin and nutrition regimen. Using our exclusive patent rights to screen genetic variations, Gene SNP DNA Analysis uncovers the ability of your genes to respond to nutritional and environmental factors that affect various areas of your health.

The best part is that the results remain accurate throughout your life since your gene makeup does not change. Since your genes don’t change, you have the ability to optimize the function of your genes through diet, exercise and nutritional supplementation. And while you can’t change your genes, you can change your lifestyle. As you progress through your Health Action Plan, following the recommendations specifically suited for you and your body, you can make changes to your online customer profile and receive an updated Health Action Plan with recommendations based on your new, healthier lifestyle.

Remember the Gene SNP Program is as easy as 1, 2, 3!
1)    Complete the Gene SNP DNA Analysis, including the Online Customer Profile
2)    Receive your Customized Health Action Plan
3)    Order your customized supplements

 

nutraMetrix® Gene SNP™ DNA Analysis (Nutrition & Fitness Kit)

 Further References

• Mae-Wan Ho, Genetic Engineering:  Dream or Nightmare? (New York: Continuum, 1999).
• Richard Dawkins, The Selfish Gene (Oxford, UK: Oxford University Press, 1976).
• Brian Goodwin, How the Leopard Changed Its Spots:  The evolution of complexity (New York: Charles Scribner's Sons, 1994).
• Ruth Hubbard and Elijah Wald, Exploding the Gene Myth:  How genetic information is produced and manipulated by scientists, physicians, employers, insurance companies, educators, and law enforcers (Boston, MA: Beacon Press, 1999).
• David Humphreys and others, A Epigenetic Instability in ES Cells and Cloned Mice,@ Science 293, no. 5527  (July  6) (2001): 95-97.
• Evelyn Fox Keller, Refiguring Life:  metaphors of Twentieth-Century biology (New York: Columbia University Press, 1995).
• MF Lee and others, Total intestinal lactase and sucrase activities are reduced in aged rats,@ The Journal of Nutrition 127, no. 7 (July) (1997): 1382-7.
• Mark E. Lowe, A Molecular mechanisms of rat and human pancreatic triglyceride lipase,@ Journal of Nutrition 127, no. 4  (April) (1997): 549-57.
• Dolinoy, D.C., et al., Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome. Environ Health Perspect, 2006. 114(4): p. 567-72.

Would You Take a Simple Test To Obtain an Inside Look at YOUR DNA?

What if you could learn about your health with a simple test, one that could give you realistic and reasonable recommendations to promote your quality of life?  Would you take it?  A current Time.com article,What Your Doctor Isn’t Telling You About Your DNA by Bonnie Rochman poses the question, should doctors share the bad news if they test a child's DNA and find that the child possesses a genetic mutation that may cause a health challenge later in life?  It is one of those questions that can be debated back and forth because there are NO right or wrong answers.  However, what most people don't know, is that there IS a simple and painless way for anybody to check their genetics...so that people can take action in accordance to their DNA.

When it comes to our bodies, we want to make choices that have a positive impact on our health. But some of those decisions – eating the wrong foods, making certain lifestyle choices, even the way we exercise – could impact our body's ability to maintain optimum health. Even if we think we’re making the right choices, there are other factors that help determine our overall picture of health.

Genetics play a huge role in how our bodies process nutrients, how they respond to activity and how we react to our environment and surroundings. When it comes to your health, the answers are in your genes. Your DNA tells a story: how you process foods, how you react to exercise, how your environment affects your body, how your family history plays a part in your health.

What if you could learn about your health with a simple test, one that could give you realistic and reasonable recommendations to promote your quality of life? It’s time to make informed decisions about your health – no more guesswork, just facts.

The Gene SNP DNA Analysis combines your individual diet, lifestyle and environment information and is scientifically merged with your genetic background to provide an exclusive Health Action Plan designed specifically for you. It will help provide practical suggestions intended to promote your health and wellness. Based on variations in your DNA and lifestyle factors, the Gene SNP DNA Analysis will make recommendations based on how your body metabolizes food, utilizes nutrients, removes toxins and responds to physical activity. By understanding how your genetic profile affects your well-being, the Gene SNP DNA Analysis will help you take charge of optimizing your wellness. The Gene SNP DNA Analysis examines a wide variety of genes and SNPs, providing a customized Health Action plan that focuses on diet, nutrition, exercise and supplementation based on your genetic profile.    

Now you can be sure your personalized Health Action Plan includes the best possible supplementation thanks to the integration of the most advanced nutraceutical products available, Isotonix. Each product has been carefully chosen to provide you with the best supplementation based on your individualized Health Action Plan. By integrating the Gene SNP DNA Analysis with the Isotonix product line, you’ll be receiving the very best supplementation support to maintain the healthiest of lifestyles.

No longer will you have to accept a “one-size-fits-all” vitamin and nutrition regimen. Using our exclusive patent rights to screen genetic variations, Gene SNP DNA Analysis uncovers the ability of your genes to respond to nutritional and environmental factors that affect various areas of your health.

The best part is that the results remain accurate throughout your life since your gene makeup does not change. Since your genes don’t change, you have the ability to optimize the function of your genes through diet, exercise and nutritional supplementation. And while you can’t change your genes, you can change your lifestyle. As you progress through your Health Action Plan, following the recommendations specifically suited for you and your body, you can make changes to your online customer profile and receive an updated Health Action Plan with recommendations based on your new, healthier lifestyle.

Frequently Asked Questions About the Gene SNP™ DNA Analysis:
What is the Gene SNP DNA Analysis?

The Gene SNP DNA Analysis is a comprehensive kit that provides a laboratory analysis of specific gene variants in your genetic material (DNA) that have been found to influence health and an Online Customer Profile survey that provides valuable information about various lifestyle habits that relate to the gene variants being tested. These two pieces of information are then analyzed together to provide you with a personalized Health Action Plan outlining diet, nutrition, exercise and supplementation recommendations.

Who should use this product?

Everyone over the age 18 concerned about how their genetic makeup plays a role in diet, nutrition and exercise should use this product.

How can understanding your genes promote a long, healthy life?Your health is a result of interactions between your genes and lifestyle factors such as diet, exercise, stress, smoking and alcohol. It is your genetic makeup that determines which nutrients are utilized, how they are used, the way toxins are removed and how effective these key processes are within the body. The best part is that the results remain accurate throughout your life since your gene makeup does not change. Since your genes don’t change, you have the ability to optimize the functioning of your genes through diet, exercise and nutritional supplementation. And while you can’t change your genes, you can change your lifestyle. As you progress through your Health Action Plan, following the recommendations specifically suited for you and your body, you can make changes to your online customer profile and receive an updated Health Action Plan with recommendations based on your new, healthier lifestyle.

Can I alter my genes through diet or lifestyle, or by using a vaccine?

No matter what we do, our genes remain the same throughout our lifetime. No amount of food or exercise can physically alter our genes. With proper nutritional supplementation and lifestyle changes, you can maintain the functioning of your gene variations to maintain optimal health.

Will you be able to tell me if I’m ill?

No, we can only determine what types of genes people have and how they relate to certain metabolic factors involved in well-being. If you think you may be ill, you should consult your doctor.

What is included in the Gene SNP DNA Analysis?

Your Gene SNP DNA Analysis kit includes:

• Access to a secure Online Customer Profile
• Bubble envelope
• Pre-addressed return FedEx stamp for the envelope
• Two swabs
• One small paper envelope
• Gene SNP booklet
• Consent form, Genetic Assessment Request Form, instructions and Gene SNP Code wallet-card

What do I do with the Consent and the Genetic Assessment Forms? 

Both forms have to be filled out and signed before the laboratory can accept your swabs for processing and DNA analysis. Send the completed forms with your swabs in the padded envelope using the prepaid shipping label to the laboratory. 

How does the Gene SNP DNA Analysis testing process work?

In the privacy of your home, you simply use a mouth swab to collect cheek cells, which contain your DNA. The swabs are put into the white swab envelope provided after drying. Send the swabs with the Genetic Assessment Request Form and the Consent Form in the padded envelope with a prepaid shipping label provided in the kit to the processing laboratory. Once at our certified laboratory, DNA is extracted from your swabs and then prepared for analysis. The DNA is analyzed using the latest genotyping technology to give the most accurate results. Your DNA analysis is then matched with the answers you provided into the Online Customer Profile. Once all of this data is compiled, it is entered into a sophisticated, algorithm-based computer software program that generates your confidential, easy-to-follow Gene SNP Health Action Plan. 

How long does it take to get my Gene SNP DNA Analysis results?

Typically, it takes three to four weeks for you to receive your Gene SNP Health Action Plan. 

How accurate are the results of my Gene SNP analysis? 

The analysis of your DNA is in compliance with the Quality Assurance and Accuracy Verification Standards of the CLIA certified laboratory. The accuracy of the genetic analysis is greater than 95 percent. 

How can my sample fail the Gene SNP DNA Analysis? 

Sometimes the sample provided does not contain enough DNA because you just brushed your teeth, or if you did not let the swabs dry long enough before putting the swabs in the envelope, or if it took too long (longer than 10 days) to reach the laboratory for analysis. It is important to follow the Swab instructions in your kit.

How is my privacy protected?

Protecting your privacy is at the core of Gene SNP DNA Analysis. We recognize your need for strong privacy protection and the careful management of your personal information. Any information you share is kept strictly confidential and is secured electronically using sophisticated encryption technology. The laboratory personnel and others who are required in the processing of your genetic results have been trained and tested to meet the requirements of Health Insurance Portability and Accountability Act (HIPAA). Your results are handled as Protected Health Information (PHI), as defined in HIPAA and regulations promulgated by the U.S. Department of Health and Human Services in accordance to that defined in 45 CFR, §160 and Subparts A and E of §164.

Should I worry about privacy issues?

Your genetic information will be encrypted and will not be directly associated with your personal information collected from your Online Customer Profile, but will be stored in a database maintained in accordance to CLIA and HIPAA standards. While this information may be used by the laboratory research affiliates to conduct further analyses for commercial purposes, under no conditions will this information be released to third parties in a way that discloses personal information, except with your written permission, unless required by law. The laboratory is vigilant against breaches of security and improves security and privacy safeguards on a regular basis.

Can I use my PCID to allow more than person to take the Online Customer Profile?

No, the PCID number is used to authenticate a unique person who is logging on and is used to identify specifically the supplements recommended for that person. 

Does my Gene SNP DNA Analysis Kit have an expiration date?You must send in your cheek swabs, consent forms and complete your Online Customer Profile within 180 days of the date the kit was purchased. All sales of the Gene SNP DNA Analysis kit are final.

Click Here to Learn More about the DNA Gene SNP Analysis Kit

Scientific Studies Which Support the Gene SNP™ DNA Screening Analysis: 
Genes associated with cholesterol metabolism, triglyceride balance, vascular flow and tissue development: APOC3, IL-6, eNOS, LPL, CETP, MTHFR:

• Brousseau, M.E., et al, Cholesteryl ester transfer protein TaqI b2b2 Genotype is associated with higher HDL cholesterol levels and lower risk of coronary heart disease end points in men with HDL deficiency: Veterans Affairs HDL Cholesterol Intervention Trial. Arterioscler Thromb Vasc Biol 22, 1148-1154 (2002)
• Brull, D.J., et al, Interleukin-6 gene -174g>c and -572g>c promoter polymorphisms are strong predictors of plasma interleukin-6 levels after coronary artery bypass surgery. Arterioscler Thromb Vasc Biol 21, 1458-1463 (2001)
• Brull, D.J., et al, The effect of the Interleukin-6-174G > C promoter gene polymorphism on endothelial function in healthy volunteers. Eur J Clin Invest 32, 153-157 (2002)
• Chen, W. et al, Combined effects of endothelial nitric oxide synthase gene polymorphism (G894T) and insulin resistance status on blood pressure and familial risk of hypertension in young adults: the Bogalusa Heart Study. Am J Hypertens 14, 1046-1052 (2001)
• Dullaart, R.P., et al, Cholesteryl ester transfer protein gene polymorphism is a determinant of HDL cholesterol and of the lipoprotein response to a lipid-lowering diet in type 1 diabetes. Diabetes 46, 2082-2087 (1997)
• Leeson, C.P., Glu298Asp endothelial nitric oxide synthase gene polymorphism interacts with environmental and dietary factors to influence endothelial function. Circ Res 90, 1153-1158 (2002)
• Miyamoto, Y., et al, Endothelial nitric oxide synthase gene is positively associated with essential hypertension. Hypertension 32, 3-8 (1998)
• Shoji, M., et al, Positive association of endothelial nitric oxide synthase gene polymorphism with hypertension in northern Japan. Life Sci 66, 2557-2562 (2000)
• Brown, C.A., et al, A common polymorphism in methionine synthase reductase increases risk of premature coronary artery disease. J Cardiovasc Risk 7, 197-200 (2000)
• Christensen, B., et al, Genetic polymorphisms in methylenetetrahydrofolate reductase and methionine synthase, folate levels in red blood cells, and risk of neural tube defects. Am J Med Genet 84, 151-157 (1999)
• Chen, J, et al, A methylenetetrahydrofolate reductase polymorphism and the risk of colorectal cancer. Cancer Res 56, 4862-4864 (1996)
• Jacques, P.F., et al, Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation 93, 7-9 (1996)
• Ma, J., et al, Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer. Cancer Res 57, 1098-1102 (1997)
• Martinez de Villarreal, L.E., et al, Folate levels and N(5),N(10)-methylenetetrahydrofolate reductase genotype (MTHFR) in mothers of offspring with neural tube defects: a case-control study. Arch Med Res 32, 277-282 (2001)
• Slattery, M.L., et al, Methylenetetrahydrofolate reductase, diet, and risk of colon cancer. Cancer Epidemiol Biomarkers Prev 8, 513-518 (1999)
• Brown, S., et al. Interaction between the APOC3 gene promoter polymorphisms, saturated fat intake and plasma lipoproteins. Atherosclerosis. 170: 307-313, 2003.
• Fisher, R., et al. Common variation in the lipoprotein lipase gene effects on plasma lipids and risk of atherosclerosis. Atherosclerosis. 135: 145-159, 1997.
• Guzik, T., et al. Relationship between the G894T (Glu298Asp variant) in endothelial nitric oxide synthase and nitric oxide-mediated endothelial function in human atherosclerosis. American Journal of Medical Genetics. 100: 130-137, 2001.
• Wallace, A., et al. Variants in the cholesterol ester transfer protein and lipoprotein lipase genes are predictors of plasma cholesterol response to dietary change. Atherosclerosis. 152: 327-336, 2000.               

Genes associated with antioxidant function and detoxification: MnSOD, SOD3, GSTM1, GSTT1, GSTP1: 

• Ambrosone, C.B., et al, Manganese superoxide dismutase 9MsSOD) genetic polymorphisms, dietary antioxidants, and risk of breast cancer. Cancer Res 59(3), 602-606 (1999)
• Hirvonen, A, et al, Association between manganese superoxide dismutase (MsSOD) gene polymorphism and breast cancer risk. Carcinogenesis 5(22), 827-829 (2001)
• Kimura, K.Y., et al, Genetic association of manganese superoxide dismutase with exudative age-related macular degeneration. Am J Ophthalmol 130(6), 769-73 (2000)
• Stoehlmacher, J., et al, A genetic polymorphism of manganese superoxide dismutase (9MnSOD) predicts for risk of colorectal cancer in young individuals. Annals of Oncology 11(Suppl 4), 59 (2000)
• Wang, X.L., et al, Plasma extracellular cuperoxide dismutase levels in an Australian population with coronary artery disease. Arterioscler Thromb Vasc Biol 18, 1915-1921 (1998)
• Purdie, D., et al, Dietary antioxidants, manganese superoxide dismutase (MnSOD), and risk of epithelial ovarian cancer. Proc. American Assoc. for Cancer Res. 43, 4227 (2002)
• Cotton, S.C., et al, Glutathione S-transferase polymorphisms and colorectal cancer: a HuGE review. Am J Epidemiol 151(1), 7-32 (2000)
• Lampe, J.W., et al, Modulation of human glutathione S-transferases by botanically defined vegetable diets. Cancer Epidemiol Biomarkers Prev 8, 787-93
• Lin, H.J., et al, Glutathione transferase GSTT1, broccoli, and prevalence of colorectal adenomas. Pharmacogenetics 12, 175-179
• Mitrunen, K.N., et al, Glutathione S-transferase M1, M3, P1, and T1 genetic polymorphisms and susceptibility to breast cancer. Cancer Epidemiol Biomarkers Prev 10(3), 229-36 (2001)
• Pool-Zobul, B, et al, Mechanisms by which vegetable consumption reduces genetic damage in humans. Cancer Epidemiol. Biomarkers Prev. 7, 891-99 (1998)
• Rock, C.L., et al, Nutrition genetics and risks of cancer. Annu Rev Public Health 21, 47-64 (2000)
• Steinkellner, H., et al, Effects of crusiferous vegetables and their constituents on drug metabolizing enzymes involved in the bioactivation of DNA-reactive dietary carcinogens. Mutation Research, 480-481,285-297 (2001)
• Ambrosone, C., et al. Manganese superoxide dismutase (MnSOD) genetic polymorphisms, dietary antioxidants, and risk of breast cancer. Cancer Research. 59(3): 602-606, 1999.
• Chistyakov, D. A., et al. Polymorphisms in the Mn-SOD and EC-SOD genes and their relationship to diabetic neuropathy in type 1 diabetes mellitus. BMC Medical Genetics. 2(1): 4, 2001.
• Parke, D.V. “Antioxidants and disease prevention: mechanisms of action”. Antioxidants in Human Health. CABI Publishing, 1999.
• Gaudet, M., et al. Diet, GSTM1, and GSTT1 and head and neck cancer. Carcinogenesis. 25(5): 735-740, 2003
• Lampe, J.W., et al. Modulation of human glutathione S-transferases by botanically defined vegetable diets. Cancer Epidemiology Biomarkers Preview. 9(8):787-793, 2000.
• Verhoeff, B., et al. The effect of a common methylenetetrahydrofolate reductase mutation on levels of homocysteine, folate, vitamin B12 and on the risk of premature atherosclerosis. Atherosclerosis. 141(1): 161-166, 1998
• Change, A., et al. The effect of 677 C T and 1298 A C mutations on plasma homocysteine and 5,10- methylenetetrahydrofolate reductase activity in healthy subjects. British Journal of Nutrition. 83(6): 593-596, 2000.
• Jacques, P., et al. Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation. 93(1): 7-9, 1996.
• Miller M., and Mohrenweiser, H. Genetic variability in susceptibility and response to toxicants. Toxicology Letters. 120(1-3): 269-280, 2001.
• Cosma, G., et al. Relationship between genotype and function of the human CYP1A1 gene. Journal of Toxicology and Environmental Health. 40(2-3): 309-316, 1993.
• Bosron, W. and Ting-Kai, L. Genetic polymorphism of human liver alcohol and aldehyde dehydrogenases, and their relationship to alcohol metabolism and alcoholism. Hepatology. 6(3):502 - 510, 1986.
• Takeshita, T. and Morimoto, K. Accumulation of hemoglobin-associated acetaldehyde with habitual alcohol drinking in the atypical ALDH2 genotype. Alcohol Clinical and Experimental Research. 24(1): 1-7, 2000.

 Genes associated with bone structure: VDR, COL1A1, IL6, TNFα: 

• Chen, H.Y., et al, Relation of vitamin D receptor FokI start codon polymorphism to bone mineral density and occurrence of osteoporosis in postmenopausal woman in Taiwan. Acta Obstet Gynecol Scan 81, 93-98 (2002)
• Dennison, E.M., at al, Birthweight, vitamin D receptor genotype and the programming of osteoporosis. Paediatr Perinat Epidemiol 15, 211-219 (2001)
• Eastell, R. and Lambert, H., Diet and healthy bones., Calcif Tissue Int 70, 400-404 (2002)
• Ferrari, S., et al, Bone mineral mass and calcium and phosphate metabolism in young men: relationships with vitamin D receptor allelic polymorphisms. J Clin Endocrinol Metab 84, 2043-2048 (1999)
• Ferrari. S.L., Osteoporosis, vitamin D receptor gene polymorphisms and response to diet. World Rev Nutr Diet 89, 83-92 (2001)
• Garnero, P., et al, Association between a functional interleukin-6 gene polymorphism and peak bone mineral density and postmenopausal bone loss in women: the ofely study. Bone 31, 43-50 (2002)
• Gong, G., et al, The association of bone mineral density with vitamin D receptor gene polymorphisms. Osteoporos Int 9, 55-64 (1999)
• Lorentzon, M., et al, Vitamin D receptor gene polymorphism is related to bone density, circulating osteocalcin, and parathyroid hormone in healthy adolescent girls. J Bone Miner Metab 19, 302-307
• MacDonald, H.M., et al, COL1A1 Sp1 polymorphism predicts perimenopausal and early postmenopausal spinal bone loss. J Bone Miner Res 16, 1634-1641 (2001)
• Mann, V., et al, A COL1A1 Sp1 binding site polymorphism predisposes to osteoporotic fracture by affecting bone density and quality. J Clin Invest 107, 899-907 (2001)
• Prentice, A., The relative contribution of diet and genotype to bone development. Proc Nutr Soc 60, 45-52 (2001)
• Ralston, S.H., Genetic control of susceptibility to osteoporosis. J Clin Endocrinol Metab 87, 2460-2466 (2002)
• Grant, S., et al. Reduced bone density and osteoporosis associated with a polymorphic Sp1 binding site in the collagen type 1 alpha 1 gene. Nature Genetics. 14: 203-205, 1996.
• Ortlepp, J., et al. The vitamin D receptor gene variant and physical activity predicts fasting glucose levels in healthy young men. Diabetic Medicine. 20: 451-454, 2003.
• Uitterlinden, A., et al. Interaction between the vitamin D receptor gene and collagen type 1alpha1 gene susceptibility for fracture. Journal of Bone and Mineral Research. 16: 379-385, 2001. 

Genes associated with inflammatory response: TNF, IL-6: 

• Abraham, L.J., et al, Impact of the -308 TNF promoter polymorphism on the transcriptional regulation of the TNF gene: relevance to disease. J Leukoc Biol 66, 552-566 (1999)
• Chung, H.Y., et al, The inflammation hypothesis of aging: molecular modulation by calorie restriction. Ann NY Acad Sci 928, 327-335 (2001)
• Grimble, R.F., Nutritional modulation of immune function. Proc Nutr Soc 60, 389-397 (2001)
• Nakajima, T., et al, Allelic variants in the interleukin-6 gene and essential hypertension in Japanese women. Genes Immun 1, 115-119 (1999)
• Terry, C.F., et al, Cooperative influence of genetic polymorphisms on interleukin 6 transcriptional regulation. J Biol Chem 275, 18138-18144 (2000)
• Vickers, M.A., et al, Genotype at a promoter polymorphism of the interleukin-6 gene is associated with baseline levels of plasma C-reactive protein. Cardiovasc Res 53, 1029-1034 (2002)
• Ferrari, S., et al. Two promoter polymorphisms regulating interleukin-6 gene expression are associated with circulating levels of C-reactive protein and markers of bone resorption in postmenopausal women. Journal of Clinical Endocrinology & Metabolism. 88: 255-259, 2003.
• Grimble R., et al. The ability of fish oil to suppress tumor necrosis factor alpha production by peripheral blood mononuclear cells in healthy men is associated with polymorphisms in genes that influence tumor necrosis factor alpha production. American Journal of Clinical Nutrition. 76(2): 454-459, 2002.
• Terry, c., et al. Cooperative influence of genetic polymorphisms on interleukin 6 transcriptional regulation. Journal of Biological Chemistry. 275: 18138-18144, 2000.
• Vendrell, J., et al. A polymorphism in the promoter of the tumor necrosis factor-alpha gene (-308) is associated with coronary heart disease in type 2 diabetic patients. Atherosclerosis. 167: 257-264, 2003.
• Witte, J.S., et al, Relation between tumour necrosis factor polymorphism TNFalpha-308 and risk of asthma. Eur J Hum Genet 10, 82-85 (2002)

Genes associated with glucose balance: VDR, PPARg2, ACE, TNF: 

• Chiu, K.C., et al, The vitamin D receptor polymorphism in the translation initiation codon is a risk factor for insulin resistance in glucose tolerant Caucasians. BMC Med Genet 2,2 (2001)
• Dalziel, B., et al, Association of the TNF-alpha -308G/A promoter polymorphism with insulin resistance in obesity. Obes Res 10, 401-407 (2002)
• Deeb, S.S., et al, A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. Nat Genet 20, 284-287 (1998)
• Dengel, D.R., et al, Exercise-induced changes in insulin action are associated with ACE gene polymorphisms in older adults. Physiol Genomics 11, 73-80 (2002)
• Kadowaki, T., et al, The role PPARgamma in high-fat diet-induced obesity and insulin resistance. J Diabetes Complications 16, 41-45 (2002)
• Nicaud, V., et al, The TNF alpha/G-308A polymorphism influences insulin sensitivity in offspring of patients with coronary heart disease: the European Atherosclerosis Research Study II. Atherosclerosis 161, 317-325 (2002)
• Paolisso, G., et al, ACE gene polymorphism and insulin action in older subjects and healthy centenarians. J Am Geriatr Soc 49, 610-614 (2001)
• Li, S., et al. The peroxisome proliferator-activated receptor-gamma2 gene polymorphism (Pro12Ala) beneficially influences insulin resistance and its tracking from childhood to adulthood: the Bogalusa Heart Study. Diabetes. 52: 1265-1269, 2003.
• Ostgren, C., et al. Peroxisome proliferator-activated receptor-gammaPro12Ala polymorphism and the association with blood pressure in type 2 diabetes: Skaraborg hypertension and diabetes project. Journal of Hypertension. 21: 1657-1662, 2003.
• Paolisso, G., et al. ACE gene polymorphism and insulin action in older subjects and healthy centenarians. Journal of American Geriatric Society. 49: 610-614, 2001.
• Perticone, F., et al. Relationship between angiotensin-converting enzyme gene polymorphism and insulin resistance in never-treated hypertensive patients. Journal of Clinical Endocrinology & Metabolism. 86: 172-178, 2001.

* These statements have not been evaluated by the Food and Drug Administration.
This product(s) is not intended to diagnose, treat, cure or prevent any disease.

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ALL the Vaccines Are Contaminated - Every Last One of Them

The article below comes from www.Salem-News.com and was published November 29, 2011.  I have not altered the text or removed the hyperlinks. This is ONE opinion. I strongly suggest you do YOUR research and make the best decision for you and your family. However, make an educated and informed decision. Do not EVER allow yourself or your family to be pushed or forced into taking anything you are not comfortable with. YOU are in charge of YOUR wellness. If you are a parent, YOU are in charge of your children's wellness. TAKE THE ROLE seriously. YOU have the rest of their lives in your hands. DO NOT TRUST anybody else. Understand your rights, educate yourself and MAKE AN INFORMED DECISION.

Nov-29-2011 01:22 
S. Edmonson for Salem-News.com

"The chief, if not the sole, cause of the monstrous increase in cancer has been vaccination" - Dr. Robert Bell, once Vice President International Society for Cancer Research at the British Cancer Hospital.

Experts say families need to take a critical look at vaccines.

(WASHINGTON, D.C.) - Have you been rushing out to get a yearly flu vaccine or diligently taking your children for the 40 or so mandated childhood vaccines?

That's really a shame because you have unwittingly been trading a run-of-the-mill flu or just the measles, for loading up your or your children's bodies with cancer and other deadly viruses, a destructive bacteria, a chemical selected to damage fertility, and with synthetic DNA that threatens to damage your own DNA - the biologic code for your existence.

Who is saying the vaccines are contaminated?

None other than the (now deceased) head of vaccines at Merck, Dr. Maurice Hillerman, who on camera admitted that Merck's Hepatitis B vaccines, contaminated with a virus, caused the AIDS epidemic in the US.  He went on to say that all of Merck's vaccines are contaminated with cancer and other viruses.  (The US government has conceded the HEB B vaccine causes Lupus. That vaccine is mandated for every infant in the US on the day of birth, and is associated with MS as well.)  That vaccine is mandated for every infant in the US on the day of birth, and is associated with MS as well.)

For Jews who have almost religiously believed in medical authorities about vaccines and poo-pooed those worried about the safety of vaccines, they might want to notice that Hillerman was Jewish.

Or they might recognize that so is Dr. Larry Palevsky, a board certified NY pediatrician, who for ten years routinely gave vaccines to his patients until he noticed them losing eye contact and then began looking into the vaccines he had blindly trusted.  He found that they are ALL contaminated with viruses that are so small they can never be removed.  He no longer gives any vaccines.  He now treats his young patients for autism and other neurologic injuries from vaccines.

Donald W. Scott, the editor of The Journal of Degenerative Diseases and the co-founder of the Common Cause Medical Research Foundation, links vaccines to AIDS (as did Hillerman) and to US bio-weapons research, and says they are contaminated with mycoplasma, a primitive bacteria that takes apart cell walls.

Perhaps the highest scientific authority saying vaccines are contaminated is Garth Nicolson. He is a cell biologist and editor of the Journal of Clinical and Experimental Metastasis, and the Journal of Cellular Biochemistry. He is one of the most cited scientists in the world, having published over 600 medical and scientific peer-reviewed papers, edited over 14 books, and served on the editorial boards of 28 medical and scientific journals. He is not just saying that vaccines are contaminated with mycoplasma but is warning the US that they are. Nicolson goes further and says that we are all being damaged by them and contracting chronic degenerative diseases that.

 That damage translates into lifelong patients (and thus life-long profit) for the pharmaceutical industry making the vaccines and he says doesn't appear to be accidental.  

According To CIA Statistics:  As Shots Increase, U.S. Lifespan Is DECREASING

1980: 9 vaccines, autism is rare
2009: 36 vaccines before age 5
2010: 55 vaccines before age 6

Vaccines vs. Autism, 2009	Vaccinations before age 5	Deaths per 1000 under 5 yrs old	Autism Rate	Lifespan Ranking
United States (c)	36	7.8	1 in 91	34
Norway	13	4.4	1 in 2,000 ab	5
Denmark	12	5.8	1 in 2,200 ab	18 d
Japan	11	4.2	1 in 475 a	4
Sweden	11	4.0	1 in 862 a	2
Iceland	11	3.9	1 in 1,1000 ab	1

All the vaccines mandated to children and many other vaccines as well, including the seasonal flu vaccines being mandated to health care workers, are contaminated with polysorbate 80, the central ingredient in a pharmaceutical industry patent to damage fertility. The pharmaceutical industry has a long history of of seeking a vaccine that would covertly sterilize whole populations So, in addition to being contaminated with cancer and other viruses, and with the bacteria mycoplasma, vaccines are intentionally "contaminated" with a chemical as well, which is, given the patent, a "patently" sought-after sterilizing agent.
 

Beyond containing polysorbate 80 and cancer and other viruses, and likely mycoplasma, the Gardasil vaccines are contaminated in an additional way.  It and all the new vaccines are contaminated with genetically engineered DNA.  It can contaminate people's DNA, just a genetically engineered crops can contaminate normal crops.  Gardasil itself is contaminated with a man-made version of the HPV DNA, the very virus it was supposed to protect against, which now it threatens not only altering kids' healthy DNA with synthetic DNA (!) but with a diseased version.  

Gardasil was suspended in India after 4 girls died but the killing has gone on in the US despite the confirmed deaths of 100 girls. and now the CDC, with special ties to Merck, its maker, wants all boys to take it, too.

Informed consent is the core of the Nuremberg Code that was created by the Nuremberg Tribunal to keep the pharmaceutical industry from ever again committing the hideous "medical" abuses it did during the Holocaust. In California, Jerry Brown is dismantling informed consent in order to get these deadly  vaccines associated with infertility, into all school children.  And it was during the Holocaust that the pharmaceutical experimented on Jewish women prisoners at Auschwitz to develop a vaccine that sterilized covertly.  Henry Kissinger recommended the development of covertly sterilizing vaccines in a major report to the US government and as late as 2009 a Finnish Health Minister said he was behind the H1N1 vaccine that was meant to lower population.

Jerry Brown has just signed into law a bill that will allow children as young as 12 to decide whether to take a vaccine for sexually transmitted disease.  Parental consent is not needed and parents will not even be allowed knowledge as to whether the child has taken the vaccine.  Merck's Hepatitis B vaccine is one that is included, as is another Merck vaccine, Gardasil, allegedly for ovarian cancer.  A Gardasil researcher says there is no evidence it works.  "This raises questions about the CDC's recommendation that the series of shots be given to girls as young as 11-years old. 'If we vaccinate 11 year olds and the protection doesn't last... we've put them at harm from side effects, small but real, for no benefit,' says Dr. Harper. 'The benefit to public health is nothing, there is no reduction in cervical cancers … ' "

Current Data for Gardasil up to AUG 12, 2011 

Disabled 763 
Deaths 103 
Did Not Recover 4777 
Abnorm. Pap Smear 430 
Cervical Dysplasia 157 
Cervical Cancer 41 
Life Threatening 444 
Emergency Rm. Visit 9115 

Hospitalized 2307 
Extended Hosp. Stay 201 
Serious 3111 
Adverse Events 23388

But these figures are based on statistics from medical professionals who do not wish to be sued.  In reality, "less than 10% of deaths, seizures, paralysis, etc., are being reported as caused by the vaccinations that doctors gave in their office.

The following real-world estimates are based on reports from a law firm:

“

840 young girls and 2 boys have died after receiving the Gardasil HPV Vaccine 201,010 young girls have suffered debilitating events such as fatigue, seizures, paralysis, etc. after receiving the Gardasil HPV Vaccine.

”

The California law even approves in advance, ALL yet-to-be made (and completely untested) vaccines for sexually transmitted diseases, though of the two current Merck vaccines they are pushing on children, one Merck vaccine caused AIDS and causes Lupus and the other Merck vaccine is contaminated in multiple ways and proving highly lethal. Children will be the ones decide whether to take the vaccines, and they will make that decision after being forced to see videos of people dying terrible deaths from cancer. Not only would the vaccine be given without parental consent, but parents are denied knowledge that the vaccine is going to be given or that it was given. If the child has a seizure or dies afterward, parents may not see their own children's medical records.

This is what is left of the "informed consent" meant to provide human rights to protect the world from pharmaceutical industry abuses against mankind.

After World War II, it was Merck which received the flight capital of the pharmaceutical industry indicted for crimes against humanity, human enslavement and mass murder.

In the case of children, rather than their facing childhood diseases of insignificant threat, they are, by legal mandate, being bombarded repeatedly throughout their childhood with viruses that cause diseases (including cancer), a cell-destroying bacteria, a a threat to the very integrity of their DNA, and a chemical specifically chosen to impair fertility.  And laws are being written to add to the already long list of vaccines they must take, including two mandated Merck vaccines.  One is an old Merck vaccine that caused AIDS and is causing Lupus.  The other is a Merck vaccine claiming to prevent cervical cancer though girls have little chance of contracting it in the first place (and boys, none!) and it can easily be detected by pap smear and treated successfully and there is NO evidence the vaccine prevents it.  Meanwhile, it is killing children.

Contamination of the polio vaccine and the continuing effects

FACT: Before the Polio Vaccine, there had never been a virus from another species deliberately injected into humans.

FACT: 61% of all human tumors (at autopsy) now contain the SV40 monkey virus, traceable to the Polio vaccine of the 1950s and 60s

FACT: CUTTER vaccine division and WYETH produced a deadly Polio vaccine with a live virus that actually gave the recipient POLIO

FACT: All above information was withheld from the public for years to avoid a public panic and to prevent a loss of faith in vaccines. polio was a very rare infectious disease that presented little risk to the public, but the risk was greatly exaggerated by the Polio Foundation before the introduction of the  polio vaccine, the miracle vaccine - contaminated with a monkey virus which has been the cause of soft tissue cancers for decades since.

Though facing no serious health risk, people are paying to have their bodies contaminated by contaminated vaccines.  In taking vaccines, they are trading the minimal risk of even contracting common diseases and which themselves are rarely dangerous and can be treated if contracted - for the absolute certainty of loading their bodies with

1. cancer and other infectious viruses,
2. a destructive bacteria, and
3. a fertility impairing chemical.

They are doing this because they are being terrorized by their own government with false information on the risks of various diseases and denied critical information on the scientific risk of the vaccines.

Those vaccines without a doubt threaten their own and their children's fertility, and their very lives.