Grapes make chemotherapy obsolete?

(Courtesy of Natural News)

Combination of two powerful nutrients in wild grapes found to destroy cancer stem cells without harming healthy cells

Grapes might be one of the smaller fruits out there, but they punch far above their weight when it comes to providing health benefits. They’ve been revered for everything from their ability to make wine to their convenience and portability compared to other superfoods. Not content to stop there, however, this overachieving fruit is now making headlines for its potential to destroy cancer stem cells.
A team of researchers at Pennsylvania State University tested the effects of grape seed extract and a polyphenol compound found in the fruit known as resveratrol. Working on the theory that nearly all cancerous tumors are fueled by cancer stem cells, they examined 52 mice who had colon cancer tumors. The animals were divided into three groups for the study, one of which was fed the combination of grape compounds. A second group was given an anti-inflammatory drug that can reduce tumors known as sulindac, while the third group stuck to a normal diet and served as the control.

50 percent decrease in tumors

In the group of mice who were fed the grape compound, the number of tumors fell by an impressive 50 percent. While a similar decrease was seen in the group taking sulindac, that group suffered gastrointestinal toxicity; those taking the grape compound did not.
Interestingly, these two nutrients did not suppress the cancer stem cells as much when they were taken in small doses separately. Instead, researchers found that they got the best results when the two were combined. Best of all, the combination is not toxic to healthy cells, which means they could form the basis of a cancer treatment that is far safer than chemotherapy.
Resveratrol is found in the skin and seed of grapes, and you can also find it in foods like pomegranates, blueberries and cranberries. Past studies have shown that it can cut your risk of heart disease and keep some types of cancer at bay, like pancreatic cancer. Grape seed extract, meanwhile, has been found to help stave off tooth decay, kill leukemia cells, and enhance brain health.

Nature has the answers

This is just the latest example of nature providing the answer to one of life’s problems. Professor Vanamala, who led the study, said that plant-based diets provide the body with vital compounds that can kill cancer stem cells, so he recommends that people eat a variety of colorful vegetables and fruits to help prevent colon cancer, promote bacterial diversity, and prevent chronic illnesses. Of course, it’s important to seek out organic produce or you could be doing more harm than good.
Professor Vanamala pointed out that cultures that eat a plant-based diet typically have the lowest rates of colon cancer, and he feels this is because their food is covering all the bases by giving people a wide variety of compounds that can target the different pathways cancer stem cells depend on for their survival.
It is hoped that these compounds’ effects can be studied on humans and eventually lead to a new solution for protecting against colon cancer and preventing its recurrence in survivors. It couldn’t come at a better time as nearly 100,000 people are expected to develop the disease this year, according to estimates from the American Cancer Society. It’s the second most common type of cancer in women and the third most common in men. Finding a safe way to destroy these cells could prove to be a game-changer in the fight against cancer. In the meantime, why not grab a handful of grapes or a glass of red wine and enjoy the benefits of resveratrol?

600 Reasons Turmeric May Be The World’s Most Important Herb

courtesy of GreenMedInfo.com

There is a medicinal spice so timelessly interwoven with the origins of human culture and metabolism, so thoroughly supported by modern scientific inquiry, as to be unparalleled in its proven value to human health and well-being.

Indeed, turmeric turns the entire drug-based medical model on its head.  Instead of causing far more side effects than therapeutic ones, as is the case for most patented pharmaceutical medications, turmeric possesses hundreds of potential side benefits, having been empirically demonstrated to positively modulate over 160 different physiological pathways in the mammalian body.

While no food or herb is right for everyone, and everything has the potential for unintended, adverse side effects, turmeric is truly unique in its exceptionally high margin of safety vis-à-vis the drugs it has been compared with, e.g. hydrocortisone, ibuprofen, chemotherapy agents. Furthermore, nothing within the modern-day pharmaceutical armamentarium comes even remotely close to turmeric’s 6,000 year track record of safe use in Ayurvedic medicine.[1]

Despite its vast potential for alleviating human suffering, turmeric will likely never receive the FDA stamp of approval, due to its lack of exclusivity, patentability and therefore profitability. Truth be told, the FDA’s “gold standard” for proving the value of a prospective medicinal substance betrays the age old aphorism: “he who owns the gold makes the rules,” and unless an investor is willing to risk losing the 800+ million dollars that must be spent upfront, the FDA-required multi-phased double-blind, randomized clinical trials will not occur. For additional details on this rather seedy arrangement read our article on the topic: Why The Law Forbids The Medicinal Use of Natural Substances.

GreenMedInfo.com has reviewed over 5,000 study abstracts from the National Library of Medicine’s bibliographic database known as MEDLINE and have discovered over 600 potential health benefits of turmeric, and/or its primary polyphenol known as curcumin. These can be viewed on our turmeric research page which is dedicated to disseminating the research on the topic to a larger audience.

Some of the most amazing demonstrated properties include:

• Destroying Multi-Drug Resistant Cancer
• Destroying Cancer Stem Cells (arguably, the root of all cancer)
• Protecting Against Radiation-Induced Damage
• Reducing Unhealthy Levels of Inflammation
• Protecting Against Heavy Metal Toxicity
• Preventing and Reversing Alzheimer’s Disease Associated Pathologies

Again, what is so amazing is not that turmeric may have value in dozens of health conditions simultaneously, or that it may improve conditions that are completely resistant to conventional treatment, but that there are over six hundred additional health conditions it may also be valuable in preventing and/or treating. Consider also the fact that turmeric grows freely on the Earth, and you will understand why its very existence threatens billions of dollars in pharmaceutical industry revenue.

*****

Curcumin Extreme

Why Curcumin Extreme!

Curcumin Extreme

There are many curcumin products on the market, but Curcumin Extreme with BCM-95® has superior bioavailability and absorption. BCM-95 contains the natural spectrum of the turmeric rhizome and is 100 percent natural. Curcumin Extreme promotes liver detoxification, promotes healthy glutathione levels and normal cellular regeneration. Taking Curcumin Extreme every day can help detoxify impurities in your body that build up over time.*
Curcumin Extreme also includes 167 mg of broccoli seed extract, a powerful source of sulphoraphane glucosinolates. Sulforaphanes support the normal production of Phase II liver detoxification enzymes, including glutathione synthase, heme-oxygenase and catalase. Sulforaphanes also support gene transcription, the process by which genetic information is copied from DNA to RNA. They also support the body’s natural defense systems. Glutathione is the master antioxidant in the human body, which serves to preserve and protect the brain and other body tissues by protecting them from the damage of free radicals. Furthermore, glutathione recycles vitamins C and E, which are also powerful antioxidants.*

_{*These statements have not been evaluated by the Food and Drug Administration. This product(s) is not intended to diagnose, treat, cure or prevent any disease.}

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Health, Wellness, and the Microwave Oven

From "Microwave And The Risk of Cancer?" by Dr. Janey Little

The ubiquitous microwave oven, loved for its convenience in defrosting, reheating and preparing meals in a matter of minutes may not be quite the indispensable kitchen asset you once thought. Based on an alternating current, the microwave oven creates an electromagnetic radiation that forces the atoms, molecules and cells within the food to reverse polarity over a billion times per second. This remarkably high frequency creates an oscillating action of the molecules within the food and the high friction created as a result is the reason why microwave ovens can so quickly generate heat in food.

However, the cells and molecules within food are delicate and cannot withstand this violent force. As a result the food molecules are torn apart and rearranged into new chemical compositions that are foreign to the human body. Unable to recognize these new configurations or radiolytic products (unknown fusions, not found in nature and resulting from radiation) that are created as a result of the action of the microwaves, the body is not able to utilize it as food, and instead deposits it in and around the cells as toxic (or effectively nuclear) waste.

This has numerous, undesirable effects on the body:

• The nutritional value of the food is significantly reduced (by 60-90%)

• Brain-damaging radiolytics are created

• Hemoglobin levels of the blood are reduced (hemoglobin is crucial for its role in carrying oxygen to all the cells of the body)

• Your immune system which is so crucial in protecting the body from cancer and other illnesses is suppressed

• Cancer-forming free radicals are released causing a higher % of cancerous cells in the blood

• Disorders of the digestive system are caused (including stomach and intestinal cancers)

Initial symptoms may present in the form of memory loss, anxiety, irritability, sleep disturbance, depression, migraines, disconnected thoughts/attention disorders, reproductive disorders, high blood pressure etc and over time, chronic degenerative diseases such as heart disease or cancer may develop.

And if this were not enough, all microwave ovens have unavoidable leaks of radiation into the environment causing radiation to you when standing in front of it.

According to the Forensic Research Document of Agricultural and Resource Economics (AREC), 'The effects of microwaved food by-products are long-term and permanent within the human body. Minerals, vitamins and nutrients of all microwaved food is reduced or altered so that the human body gets little or no benefit, or the human body absorbs altered compounds that cannot be broken down.'

When microwaves destroy the nutritional content of our food, our cells are starved of nutrients and our immune system is overburdened with dealing with a build-up of this unrecognizable toxic waste in the body. When we consider that this process of toxin accumulation in and around the cells contributes to the suffocation of cells from oxygen - the primary cause of cancer - it leads one to ask the question......could it be coincidence then that the cancer epidemic is most prevalent in the countries of the western world that rely so heavily on the microwave oven??

In summary, the microwave oven must be considered an insidious threat to long term health and simply has no place in your home if vibrant health is something you aspire to!

 

*****

Years ago, when our son was in middle school, he had to complete a science project.  His project was to grow (from seed) and water two plants.  One seed received "standard" filtered tap water and the other seed received water that was first microwaved.  He photographed the results day by day.  The seed that received standard tap water grew as expected.  The seed that received microwaved water never sprouted.  After this project, we discarded our microwave oven.

PAB - Lose Sickness and Find Wellness

*****

Vitamin D protects against colon cancer: Study

Courtesy International News Network

A new study has confirmed the pivotal role of vitamin D, specifically its receptor (VDR), in slowing down the action of a key protein in the carcinogenic transformation process of colon cancer cells.

Researchers at the Vall d`Hebron Institute of Oncology (VHIO) collaborated with the Alberto Sols Institute of Biomedical Research (CSIC-UAB) for the study. 

This protein, known as beta-catenin, which is normally found in intestinal epithelial cells where it facilitates their cohesion, builds up in large quantities in other areas of the cells when the tumor transformation begins.
As a result of these changes, the protein is retained in the cell nucleus, where it facilitate the carcinogenic process, and this is the point at which vitamin D intervenes, or rather, the vitamin D receptor (VDR). 

“Our study has confirmed the pivotal role of the VDR in controlling the anomalous signal that sparks off the growth and uncontrolled proliferation of colon cells which, in the final instance, ends up causing a tumor to emerge,” said Hector Palmer, the coordinator of the study and head of the VHIO’s Stem Cells and Cancer laboratory. 

“The stimulation of this receptor suppresses the action of the beta-catenin protein, intercepting the series of events that change the intestinal cell into a malignant tumor cell,” he added. 

The researchers analyzed the effect of the VDR on human colon cancer cell cultures and observed that the concentration of the altered protein, beta-catenin, increased in cells without the VDR.
In light of these findings, chronic vitamin D deficiency represents a risk factor in the development of more aggressive colon tumors. 

These results were being published in the journal PLoS One.

*****

nutraMetrix Isotonix Vitamin D with K2 contains vitamin D3, the metabolically active form of vitamin D, along with vitamin K2, a form of vitamin K which supports vascular health and calcium utilization. Vitamin D plays an important role in bone health, heart health and immune support, while working with vitamin K to support normal absorption of calcium and promote healthy arteries. nutraMetrix Isotonix Vitamin D is the first of its kind to deliver both of these powerful vitamins with isotonic delivery.

Vitamin K is included in nutraMetrix Isotonix Vitamin D with K2 because of its unique partnership with vitamin D. Vitamins K and D work together to support calcium absorption and utilization. Vitamin K supports the normal delivery of calcium to the bones and promotes healthy arteries.
At least two naturally-occurring forms of vitamin K have been identified and are known as K1 and K2. While there are many similarities between these two forms of vitamin K, they are distinguished by their important differences. The most significant difference between K1 and K2 is their chemical structure which results in different pharmacokinetic properties. Vitamin K1 is retained primarily in the liver where, at high doses, it may interfere with the action of warfarin and other anticoagulant medications.  

Vitamin K2 has a different mechanism of action. It is transported primarily to bones and blood vessels. Vitamin K2 helps to maintain bone mass, support calcium utilization and promote elasticity of blood vessels.   


Some studies have concluded that vitamin K2 does not interfere with anticoagulant medications.* However, most products containing vitamin K (including K1 and/or K2) warn users taking anticoagulants not to take the product. If you are currently taking warfarin or another anticoagulant medication, you should consult your physician before taking any product containing vitamin K1 or K2.

Isotonix dietary supplements are delivered in an isotonic solution. This means that the body has less work to do to obtain maximum absorption of the nutrients. The isotonic state of the suspension allows nutrients to pass directly into the small intestine and rapidly absorb into the bloodstream. With Isotonix products, little nutritive value is lost, making the absorption of nutrients highly efficient while delivering maximum results.

For Smokers, Low Levels of Vitamin D May Lead to Cancer

WASHINGTON, March 15, 2013 /PRNewswire/ -- New research appearing online today in Clinical Chemistry, the journal of AACC, shows that decreased levels of vitamin D may predispose smokers to developing tobacco-related cancer. This study illustrates that simple vitamin D blood tests and supplements have the potential to improve smokers' health.

In the U.S. alone, cigarette smoking accounts for more deaths annually than HIV, illegal drugs, alcohol, motor vehicle injuries, suicides, and murders combined. It is the primary causal factor for at least 30% of all cancer deaths, and can lead to multiple kinds of cancer, including bladder, cervical, esophageal, head and neck, kidney, liver, lung, pancreatic, and stomach, as well as myeloid leukemia. According to the Centers for Disease Control and Prevention, the healthcare expenditures and productivity losses due to smoking cost the economy approximately $193 billion per year. 

In this paper, Afzal et al. measured plasma vitamin D levels in blood samples collected in 1981–1983 from 10,000 Danes from the general population. Researchers then followed the study participants for up to 28 years through the Danish Cancer Registry. Of the participants, 1,081 eventually developed a tobacco-related cancer. The authors determined that the median vitamin D concentration among these participants was only 14.8 ng/mL, versus the higher 16.4 ng/mL median concentration found for all participants together.

These results show for the first time that the risk of tobacco-related cancers as a group is associated with lower concentrations of vitamin D. The data also indicate that tobacco smoke chemicals may influence vitamin D metabolism and function, while vitamin D may conversely modify the carcinogenicity of tobacco smoke chemicals. If further research confirms this, it would be consistent with previous studies demonstrating the anti-tumorigenic effects of vitamin D derivatives, as well as the correlation of vitamin D deficiency with favorable cancer-forming conditions and increased susceptibility to tobacco smoke carcinogens. Interestingly, though, low vitamin D levels were not connected with risk of other cancer types.

"Our analyses show that the association between lower concentrations of plasma vitamin D and higher risk of cancer may be driven by tobacco-related cancer as a group, which has not been shown before," stated author Borge G. Nordestgaard, MD, DMSc, in the paper. "This is important for future studies investigating the association between plasma vitamin D and risk of cancer."

About AACC
The American Association for Clinical Chemistry, AACC, brings together the global laboratory medicine community in the pursuit of improving health and healthcare through laboratory medicine. With more than 8,500 members including MDs, PhDs, research scientists, and others involved in developing tests and directing laboratory operations, AACC advances scientific collaboration, knowledge, expertise and innovation through its many programs, publications and initiatives. For more information, visit www.aacc.org  

Clinical Chemistry is the leading international journal of clinical laboratory science, providing 2,000 pages per year of peer-reviewed papers that advance the science of the field. With an impact factor of 7.9, Clinical Chemistry covers everything from molecular diagnostics to laboratory management.

Molly Polen
AACC
Director of Communications & PR
(p) 202.420.7612
(c) 703.598.0472
mpolen@aacc.org

SOURCE AACC

****

 

 

nutraMetrix Isotonix® Vitamin D with K2

 

Primary Benefits of nutraMetrix Isotonix® Vitamin D with K2*:

• Promotes normal bone mineral density
• Promotes healthy arteries
• Supports immune health
• Helps maintain bone health
• Helps maintain bone mass by supporting normal osteoclast activity
• Helps maintain cardiovascular health
• Promotes elasticity of blood vessels
• Helps maintain normal blood pressure
• Women with low bone density have been found to be deficient in vitamin K

Key Ingredients Found in nutraMetrix Isotonix® Vitamin D with K2:

Vitamin D3 (Cholecalciferol) 5000 IU
Vitamin D is a fat-soluble vitamin that is found in some foods and endogenously produced when sunlight strikes the skin and activates vitamin D synthesis. Vitamin D promotes the efficient intestinal absorption of calcium, primarily in the duodenum and jejunum by supporting the synthesis of calcium-binding proteins to promote normal calcium absorption and retention. Vitamin D also promotes the normal formation of bone and normal bone growth and bone remodeling by osteoblasts and osteoclasts. Vitamin D deficiency can be caused by factors such as lack of exposure to sunlight, reduced skin synthesis of vitamin D, lower dietary intake, impaired intestinal absorption and reduced metabolism to active forms of vitamin D by the kidneys, all of which increase with aging. Deficiency has been linked to numerous health concerns, and insufficient levels of this vitamin are associated with weak bones and  muscle weakness. In addition to promoting strong bones, vitamin D also has other roles in health, including supporting the body’s normal modulation of neuromuscular function and immune function. Vitamin D has been shown to support immune-modulation, and it is thought that supplementation promotes immune health by promoting the body’s normal regulation of T-cell function. In reference to cellular health, vitamin D supports the modulation of many genes that are responsible for encoding proteins that regulate normal cell cycle activity. Vitamin D levels have been strongly correlated to healthy cells. Lastly, through its interaction with VDR (vitamin D receptor), vitamin D supports the healthy expression of the gene encoding renin, thus helping to maintain healthy blood pressure.*

Vitamin K2 45 mcg
Vitamin K is a fat-soluble vitamin found in meat, eggs, dairy and natto. Although a fat-soluble vitamin, the body stores very little K2, and its stores are rapidly depleted without regular dietary intake. Natural vitamin K2, also known as menaquinone-7 (MK-7), is the most bioavailable form of K2 and has the longest half-life in the blood of any form of vitamin K. The Japanese soy food natto is particularly rich in menaquinone-7 (MK-7). Studies of natto consumption in Japan have linked menaquinone-7 to bone and cardiovascular health. The correlation of vitamin K to cardiovascular and bone health directly focuses on supporting proper calcium utilization, whereby adequate metabolism of calcium supports arterial and bone health. This is often referred to as the calcium paradox. The calcium paradox is explained simply as getting calcium in the right place (i.e., into the bone structures instead of the arterial vessel walls.) These events are dependent upon the synthesis of the vitamin K-dependent proteins osteocalcin and matrix Gla protein in a process called carboxylation. The carboxylation of these proteins is a post-translational step; that is, osteocalcin and matrix Gla protein are translated from their respective messenger RNA and then modified by enzymes to the active forms. These carboxylated forms support the healthy binding and releasing of calcium. This reaction is essential for optimal and healthy utilization of calcium. Vitamin K2 promotes the synthesis of proteins involved with calcium utilization, thereby supporting bone retention and arterial health. While Vitamin D supports the healthy regulation and synthesis of osteocalcin, the mineral-binding capacity of this protein requires vitamin K-dependent carboxylation and is thought to be related to bone mineralization. Gas6 is a vitamin K-dependent protein found throughout the nervous system, as well in the heart, lungs, stomach, kidneys and cartilage. Although the exact mechanism of its action has not been determined, Gas6 appears to be a cellular growth regulator involved in cellular activities such as cell adhesion, cell proliferation and protection against apoptosis.*

Scientific Studies Which Support nutraMetrix Isotonix® Vitamin D with K2:

·         Knapen M et al. Vitamin K2 supplementation improves hip bone geometry and bone strength indices in postmenopausal women. Osteoporosis International. 18(7):963-72, 2007.

·         Shiraki, M., et al.  Vitamin K2 (menatetrenone) effectively prevents fractures and sustains lumbar bone mineral density in osteoporosis.  Journal of Bone & Mineral Research.  15:515-522, 2000.

·         Hiruma Y et al.  Vitamin K(2) and geranylgeraniol, its side chain component, inhibited osteoclast formation in a different manner.  Biochemical Biophysical Research Communications.  314(1):24-30, 2004.

·         Plaza S and Lamson D. Vitamin K2 in bone metabolism and osteoporosis. Alternative Medicine Reviews. 10(1):24-35, 2005. Review.

·         Kameda T et al.  Vitamin K2 inhibits osteoclastic bone resorption by inducing osteoclast apoptosis.  Biochemical and Biophysical Research Communications.  220(3):515-519, 1996.

·         Taira H et al.  Menatetrenone (vitamin K2) acts directly on circulating human osteoclast precursors.  Calcified Tissue International. 73(1):78-85, 2003.
Hidaka T et al.  Treatment for patients with postmenopausal osteoporosis who have been placed on HRT and show a decrease in bone mineral density: effects of concomitant administration of vitamin K(2).  Journal of Bone and Mineral Metabolism.  20(4):235-239, 2002.

·         Iwamoto J et al.  Effects of vitamin K2 on osteoporosis.  Current Pharmaceutical Design.  10(21):2557-2576, 2004.

·         Iwamoto J et al. Treatment with vitamin D3 and/or vitamin K2 for postmenopausal osteoporosis. The Keio Journal of Medicine. 2003 Sep;52(3):147-50. Review.

·         Neogi, T., et al.  Low vitamin K status is associated with osteoarthritis in the hand and knee.  Arthritis and Rheumatism.  54(4):1255-1261, 2006.
Price P.  Role of vitamin K-dependent proteins in bone metabolism.  Annual Review of Nutrition.  8:565-583, 1988.

·         Bekner K.  The vitamin K-dependent carboxylase.  Journal of Nutrition.  130(8):1877-1880, 2000.

·         Nelsestuen G et al.  Vitamin K-dependent proteins.  Vitamins and Hormones.  58:355-389, 2000.

·         Shearer M.  Role of vitamin K and Gla proteins in the pathophysiology of osteoporosis and vascular calcification.  Current Opinion in Clinical Nutrition and Metabolic Care.  3(6):433-438, 2000.

·         Gundberg C et al.  Vitamin K status and bone health:  an analysis of methods for determination under carboxylated osteocalcin.  Journal of Clinical Endocrinology and Metabolism.  83(9):3258-3266, 1998.

·         Weber P.  Management of osteoporosis: is there a role for vitamin K?  International Journal for Vitamin and Nutrition Research.  67(5):350-6, 1997.

·         Garber, A. K., et al.  Comparison of phylloquinone bioavailability from food sources or a supplement in human subjects.  Journal of Nutrition.  129(6):1201-1203, 1999.

·         Binkley N et al.  Vitamin K nutrition and osteoporosis. Journal of Nutrition.  125(7):1812-1821, 1995.

·         Bischoff-Ferrari Het al.  Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials.  JAMA.  293(18):2257-2264, 2005.

·         Guirguis-Blake J et al.  Oral vitamin D3 decreases fracture risk in the elderly.  Journal of Family Practice.  52(6):431-435, 2003.

·         Schaafsma, A., et al.  Vitamin D3 and vitamin K1 supplementation of Dutch postmenopausal women with normal and low bone mineral densities:  effects on serum 25-hydroxyvitamin D and carboxylated osteocalcin.  European Journal of Clinical Nutrition.  54:626-631, 2000.

·         Trivedi Det al.  Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial.  British Medical Journal.  326(7387):469, 2003.

·         Van den Berghe G et al.  Bone turnover in prolonged critical illness: effect of vitamin D.  Journal of Clinical Endocrinology and Metabolism.  88(10):4623-4632, 2003.

·         Chapuy M et al.  Vitamin D3 and calcium to prevent hip fractures in the elderly women. New England Journal of Medicine. 327(23):1637-1642, 1992.

·         Grant W and Holick M. Benefits and requirements of vitamin D for optimal health. Alternative Medicine Review. 10:94-111, 2005.

·         Plaza S and Lamson D. Vitamin K2 in bone metabolism and osteoporosis. Alternative Medicine Reviews. 10(1):24-35, 2005. Review.

·         Zitterman A et al.  Low vitamin D status: a contributing factor in the pathogenesis of congestive heart failure?  Journal of the American College of Cardiology.  41(1):105-112, 2003.

·         Schleithoff S et al.  Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: a double-blind, randomized, placebo-controlled trial.  American Journal of Clinical Nutrition. 83(4):754-759, 2006.
Argiles A et al.  Blood pressure is correlated with vitamin D(3) serum levels in dialysis patients.  Blood Purification.  20(4):370-375, 2002.

·         Kristal-Boneh E et al.  Association of calcitriol and blood pressure in normotensive men.  Hypertension.  30(5):1289-1294, 1997.

·         Li Y et al.  1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system.  Journal of Clinical Investigation.  110(2):229-238, 2002.

·         Li Y et al.  Vitamin D regulation of the renin-angiotensin system.  Journal of Cell Biochemistry.  88(2):327-331, 2003.

·         Li Y et al.  Vitamin D: a negative endocrine regulator of the renin-angiotensin system and blood pressure.  Journal of Steroid Biochemistry and Molecular Biology.  89-90(1-5):387-392, 2004.

·         Pfeifer M et al.  Effects of a short-term vitamin D(3) and calcium supplementation on blood pressure and parathyroid hormone levels in elderly women.  Journal of Clinical Endocrinology and Metabolism.  86(4):1633-1637, 2001.

·         Sigmund C.  Regulation of renin expression and blood pressure by vitamin D(3).  Journal of Clinical Investigation.  110(2):155-156, 2002.
Vasquez A et al.  The clinical importance of vitamin D (cholecalciferol):  a paradigm shift with implications for all healthcare providers.  Alternative Therapies.  10(5):28-38, 2004.

·         Nimptsch K et al. Dietary intake of vitamin K and risk of prostate cancer in the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition. American Journal of Clinical Nutrition. 87:985-992, 2008.

·         Habu D et al.  Role of vitamin K2 in the development of hepatocellular carcinoma in women with viral cirrhosis of the liver.  JAMA.  292(3):358-361, 2004.

·         Yoshida T et al.  Apoptosis induction of vitamin K2 in lung carcinoma cell lines: the possibility of vitamin K2 therapy for lung cancer.  International Journal of Oncology.  23(3):627-632, 2003.

·         Lamson D and Plaza S. The anticancer effects of vitamin K. Alternative Medicine Review. 8(3):303-18, 2003.
Yokoyama T et al.  Combination of vitamin K2 plus imatinib mesylate enhances induction of apoptosis in small cell lung cancer cell lines.  International Journal of Oncology.  26(1):33-40, 2005.

·         Chlebowski R et al.  Vitamin K in the treatment of cancer.  Cancer Treatment Review.  12:49-63, 1985.

·         Lamson D et al.  The anticancer effects of vitamin K.  Alternative Medicine Review.  8(3):303-318, 2003.

·         Hitomi M et al. Antitumor effects of vitamins K1, K2 and K3 on hepatocellular carcinoma in vitro and in vivo.  International Journal of Oncology.  26(3):713-720, 2005.

·         Nouso K et al.  Regression of hepatocellular carcinoma during vitamin K administration.  World Journal of Gastroenterology.  11(42):6722-6724, 2005.

·         Blackmore K et al. Vitamin D from dietary intake and sunlight exposure and the risk of hormone-receptor-defined breast cancer. American Journal of Epidemiology. 168(8):915-24, 2008.

·         Deluca H et al.  Vitamin D: its role and uses in immunology.  FASEB Journal. 15(14):2579-2585, 2001.
Adorini L.  Immunomodulatory effects of vitamin D receptor ligands in autoimmune diseases.  International Immunopharmacology.  2(7):1017-1028, 2002.

·         Cantorna M et al.  Mounting evidence for vitamin D as an environmental factor affecting autoimmune disease prevalence.  Experimental Biology and Medicine (Maywood).  229(11):1136-1142, 2004.

·         Cantorna M. Vitamin D and autoimmunity: is vitamin D status an environmental factor affecting autoimmune disease prevalence? Society for Experimental Biology and Medicine. 223:230-233, 2000.

·         Garland C et al.  The role of vitamin D in cancer prevention.  American Journal of Public Health.  96(2):252-61, 2006.

·         Giovannucci E et al.  Prospective study of predictors of vitamin D status and cancer incidence and mortality in men.  Journal of the National Cancer Institute.  98(7):451-459, 2006.

·         Holick, M.  Vitamin D:  Its role in cancer prevention and treatment.  Progress in Biophysics and Molecular Biology. 92(1):49-59, 2006.

·         Gorham E et al.  Vitamin D and prevention of colorectal cancer.  Journal Steroid Biochemistry and Molecular Biology. 97(1-2):179-94, 2005.

·         Grant W et al.  Reviews: A critical review of studies on vitamin D in relation to colorectal cancer.  Nutrition and Cancer.  48(2):115-123, 2004.

·         Harris D et al.  Vitamin D and colon carcinogenesis.  Journal of Nutrition.  134(12):3463S-3471S, 2004.

·         Hayes C et al.  The immunological functions of the vitamin D endocrine system.  Cellular and Molecular Biology.  49(2):277-300, 2003.

What Makes nutraMetrix Isotonix® Vitamin D with K2 Unique?

nutraMetrix Isotonix Vitamin D with K2 contains vitamin D3, the metabolically active form of vitamin D, along with vitamin K2, a form of vitamin K which supports vascular health and calcium utilization. Vitamin D plays an important role in bone health, heart health and immune support, while working with vitamin K to support normal absorption of calcium and promote healthy arteries. nutraMetrix Isotonix Vitamin D is the first of its kind to deliver both of these powerful vitamins with isotonic delivery.

Vitamin K is included in nutraMetrix Isotonix Vitamin D with K2 because of its unique partnership with vitamin D. Vitamins K and D work together to support calcium absorption and utilization. Vitamin K supports the normal delivery of calcium to the bones and promotes healthy arteries.

At least two naturally-occurring forms of vitamin K have been identified and are known as K1 and K2. While there are many similarities between these two forms of vitamin K, they are distinguished by their important differences. The most significant difference between K1 and K2 is their chemical structure which results in different pharmacokinetic properties. Vitamin K1 is retained primarily in the liver where, at high doses, it may interfere with the action of warfarin and other anticoagulant medications. 

Vitamin K2 has a different mechanism of action. It is transported primarily to bones and blood vessels. Vitamin K2 helps to maintain bone mass, support calcium utilization and promote elasticity of blood vessels.  

Some studies have concluded that vitamin K2 does not interfere with anticoagulant medications.* However, most products containing vitamin K (including K1 and/or K2) warn users taking anticoagulants not to take the product. If you are currently taking warfarin or another anticoagulant medication, you should consult your physician before taking any product containing vitamin K1 or K2.

Isotonix dietary supplements are delivered in an isotonic solution. This means that the body has less work to do to obtain maximum absorption of the nutrients. The isotonic state of the suspension allows nutrients to pass directly into the small intestine and rapidly absorb into the bloodstream. With Isotonix products, little nutritive value is lost, making the absorption of nutrients highly efficient while delivering maximum results.

Related terms: vitamin D, vitamin K, bone health, cardiovascular health, immune support, D3, K2

Frequently Asked Questions about nutraMetrix Isotonix® Vitamin D with K2:

Why is vitamin K included in nutraMetrix Isotonix Vitamin D with K2?
Vitamin K is included in this product because of its unique partnership with vitamin D. Vitamins K and D work together to promote healthy calcium absorption and utilization. Vitamin K supports the delivery of calcium to the bones and helps maintain arterial health.* 

Is nutraMetrix Isotonix Vitamin D with K2 safe for people on anticoagulant medications?Some studies have concluded that vitamin K2 does not interfere with anticoagulant medications. However, most products containing vitamin K (including K1 and/or K2) warn users taking anticoagulants not to take the product. If you are currently taking warfarin or another anticoagulant medication, you should consult your physician before taking any product containing vitamin K1 or K2.

How do I take nutraMetrix Isotonix Vitamin D with K2?
Mix one capful of Isotonix Vitamin D with K2 with 2 ounces of water. Take one serving daily.

Is it safe to take more than 1 serving of this product daily?
One serving daily of Isotonix Vitamin D with K2 is recommended. Check with your physician before taking additional daily servings of this product.

Is there a toxicity level for vitamin D?
The recommended daily Upper Limit for vitamin D is 10,000 IU, however, safety studies indicate that up to 40,000 IU may be safe for most people. If you wish to take more than one daily serving of this product, you should check with your physician.

What are dietary sources of vitamin D?
Foods rich in vitamin D include cod liver oil, salmon, mackerel and tuna.

* These statements have not been evaluated by the Food and Drug Administration.
This product(s) is not intended to diagnose, treat, cure or prevent any disease.

Orlampa Enterprises, Inc. specializes in helping individuals, groups, & companies lose sickness and find wellness through the implementation of science based wellness programs.

Orlampa Enterprises also helps health care professionals implement holistic wellness programs into their existing practices with the goal to educate both the health care providers, their staffs, and the patients. The programs, which provide the health care professional with a substantial additional income stream in this ever changing medical marketplace, allow the patient to achieve true wellness instead of receiving a traditional treatment for symptoms.

Orlampa Enterprises is an internet based product broker specializing in personalized health and wellness related services. Orlampa Enterprises is primed to continue its growth by duplicating its successful business model of educating, training, and developing entrepreneurial leaders as business partners. As an Unfranchise™ business owner, Orlampa Enterprises, proudly utilizes highly researched products including nutraMetrix® nutritional supplements. 

 Orlampa Enterprises' motto is "Eat well, exercise, and supplement intelligently."

Contact Beth at bb@orlampa.com or 727.492.8212 for more information about nutraMetrix® partnership opportunities available.

 

 

The Power of Vitamin D

Learn More

Evidence Shows Vitamin D Helps Slow Cancer Cells

November 26, 2012

By: Lee Rannals : courtesy of redOrbit.com

McGill University researchers have discovered vitamin D helps to slow the progression of cells of cancer from premalignant to malignant states.

The researchers reported in the journal Proceedings of the National Academy of Sciences vitamin D helps to inhibit both the production and function of the protein cMYC, which drives cell division and is active at elevated levels in more than half of all cancers.

Vitamin D has been known to have a wide range of physiological effects. Scientists have understood that a correlation exists between insufficient amounts of vitamin D and increased incidence of a number of cancers.
The correlations between the vitamin and cancers are strong for those cancers of the digestive tract, including colon cancer and certain forms of leukemia.

“For years, my lab has been dedicated to studying the molecular mechanisms of vitamin D in human cancer cells, particularly its role in stopping their proliferation,” Professor John White of the Faculty of Medicine’s Department of Physiology, said in a statement.

Vitamin D can be obtained from limited dietary sources as well as from direct exposure to the sun during the spring and summer months. Having a lack of exposure to the sun, mixed with a combination of poor dietary intake, has created vitamin D deficiency or insufficiency in large populations around the world. White said the team discovered vitamin D controls both the rate of production and the degradation of cMYC. They also found it strongly stimulates the production of a natural antagonist of cMYC known as MXD1, which shuts down cMYC function.

For the study, the researchers applied vitamin D to the skin of mice and observed a drop in the level of cMYC, discovering evidence of a decrease in its function. They also found strongly elevated levels of cMYC in a number of tissues, including skin and the lining of the colon.

“Taken together, our results show that vitamin D puts the brakes on cMYC function, suggesting that it may slow the progression of cells from premalignant to malignant states and keep their proliferation in check,” White said in the statement.

He said the team hopes the study will encourage people to maintain adequate vitamin D levels. Also, he said they hope the results will stimulate the development of large trials to test the effects of adequate supplementation.

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nutraMetrix Isotonix® Vitamin D with K2

What Makes nutraMetrix Isotonix® Vitamin D with K2 Unique?

nutraMetrix Isotonix Vitamin D with K2 contains vitamin D3, the metabolically active form of vitamin D, along with vitamin K2, a form of vitamin K which supports vascular health and calcium utilization. Vitamin D plays an important role in bone health, heart health and immune support, while working with vitamin K to support normal absorption of calcium and promote healthy arteries. nutraMetrix Isotonix Vitamin D is the first of its kind to deliver both of these powerful vitamins with isotonic delivery.

Vitamin K is included in nutraMetrix Isotonix Vitamin D with K2 because of its unique partnership with vitamin D. Vitamins K and D work together to support calcium absorption and utilization. Vitamin K supports the normal delivery of calcium to the bones and promotes healthy arteries.

At least two naturally-occurring forms of vitamin K have been identified and are known as K1 and K2. While there are many similarities between these two forms of vitamin K, they are distinguished by their important differences. The most significant difference between K1 and K2 is their chemical structure which results in different pharmacokinetic properties. Vitamin K1 is retained primarily in the liver where, at high doses, it may interfere with the action of warfarin and other anticoagulant medications. 

Vitamin K2 has a different mechanism of action. It is transported primarily to bones and blood vessels. Vitamin K2 helps to maintain bone mass, support calcium utilization and promote elasticity of blood vessels.  

Some studies have concluded that vitamin K2 does not interfere with anticoagulant medications.* However, most products containing vitamin K (including K1 and/or K2) warn users taking anticoagulants not to take the product. If you are currently taking warfarin or another anticoagulant medication, you should consult your physician before taking any product containing vitamin K1 or K2.

Isotonix dietary supplements are delivered in an isotonic solution. This means that the body has less work to do to obtain maximum absorption of the nutrients. The isotonic state of the suspension allows nutrients to pass directly into the small intestine and rapidly absorb into the bloodstream. With Isotonix products, little nutritive value is lost, making the absorption of nutrients highly efficient while delivering maximum results.

 

Orlampa Enterprises, Inc. specializes in helping individuals, groups, & companies lose sickness and find wellness through the implementation of science based wellness programs.

Orlampa Enterprises also helps health care professionals implement holistic wellness programs into their existing practices with the goal to educate both the health care providers, their staffs, and the patients. The programs, which provide the health care professional with a substantial additional income stream in this ever changing medical marketplace, allow the patient to achieve true wellness instead of receiving a traditional treatment for symptoms.

Orlampa Enterprises is an internet based product broker specializing in personalized health and wellness related services. Orlampa Enterprises is primed to continue its growth by duplicating its successful business model of educating, training, and developing entrepreneurial leaders as business partners. As an Unfranchise™ business owner, Orlampa Enterprises, proudly utilizes highly researched products including nutraMetrix® nutritional supplements. 

 Orlampa Enterprises' motto is "Eat well, exercise, and supplement intelligently."

Contact Beth at bb@orlampa.com or 727.492.8212 for more information about nutraMetrix® partnership opportunities available.

 

 

Resveratrol helps in fight against cancer

By Janese Silvey

Courtesy of the Columbia Daily Tribune

Saturday, December 1, 2012

A compound found in grapes can make prostate tumor cells more susceptible to radiation treatment, increasing a patient's chances of recovery, a University of Missouri researcher has found. 

Michael Nicholl, an assistant professor of surgical oncology in the MU School of Medicine, tested resveratrol on cells relatively resistant to radiation. He found that when the compound is added, the cells stopped growing and died at a much faster rate than when treated by either the compound or the radiation alone. 

Resveratrol is found in grape skins, red wine and also in over-the-counter pill form at health food stores.The finding isn't an excuse to up one's intake of wine, though. 

Although there might be some benefits to that, Nicholl stressed that his study only tested high doses delivered right to the tumor cells. In real-world scenarios, injecting large doses of resveratrol would cause harmful side effects. 

"What we really need to design is a nice delivery mechanism for higher doses to be effective," he said. Nicholl also discovered the resveratrol activated two proteins that further assisted in the fight against the cancer cells. 

The next step is to test the treatment in an animal model before clinical tests could be initiated. Nicholl anticipates studies on mice in the next several months. 

If additional studies are successful in the next few years, MU will request authority from the federal government to begin human drug testing that could lead to clinical trials. 

His initial study was published in the Journal of Andrology and Cancer Science. 

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nutraMetrix Isotonix® Resveratrol

Primary Benefits of nutraMetrix Isotonix® Resveratrol*:

• Maintains cell health
• Promotes normal cell cycle activity
• Promotes apoptosis (programmed cell death) in unhealthy cells
• Promotes normal nuclear factor kappa B (NF-Kappa B – protein) and cyclooxygenase-2 (COX-2 - enzyme) activity
• Promotes normal activity of the SIRT-1 gene (involved in calorie restriction, fat mobilization, mitochondrial function)
• Promotes cardiovascular health (promotes normal platelet activity, helps maintain normal vasorelaxation, provides antioxidant protection of LDL particles).
• Superior antioxidant and high ORAC value
• Promotes a healthy prostate gland
• Helps promote apoptosis in unhealthy prostate cells

Key Ingredients Found In nutraMetrix® Isotonix® Resveratrol:

Resveravine® (20% resveratrol extract): 10 mg

Resveratrol is a natural antioxidant found in red wine. Resveravine is a natural extract from Vitis vinifera standardized to contain 20% oligostilbenes. Resveravine is 100 to 300 times more concentrated in trans-resveratrol than other products made from grape skin. It provides antioxidant protection of low-density lipoprotein (LDL) particles, promotes normal platelet activity, vasorelaxation and blood flow, all which support cardiovascular health. It has been shown to promote apoptosis (programmed cell death) in unhealthy cells. Another proposed mechanism of action involves the study of the SIRT-1 gene (also known as the longevity gene). Sirtuins, known as Silent Information Regulators (SIRs), are deacetylase enzymes identified in all living creatures. Sirtuin proteins are known to play an important role in keeping regions of chromosomes turned off. Sirtuin controls the enzyme that converts acetate, a source of calories, into acetyl-CoA, a key component of cellular respiration. In humans, there are seven different sirtuins, SIRT-1 to SIRT-7. SIRT-1 has been studied by scientist for its potential effect on human cell lifespan.*

Resveratrol promotes normal activity of SIRT-1. Studies have shown that SIRT-1 activates a critical component of calorie restriction in mammals and promotes fat mobilization. The most recent study (Nature 2006) demonstrated that obese mice fed red wine extract (resveratrol) were in better health and lived longer than obese mice that were not fed the red wine extract. The resveratrol group were more able to maintain heart health compared to mice that were not fed resveratrol. SIRT-1 activation also supports healthy mitochondrial function and supports energy expenditure. Resveratrol has also been shown to have phytoestrogen activity and may support optimal estradiol activity. Other studies have documented neuroprotective benefits associated with resveratrol supplementation.*

A comparison test was made to evaluate the activating effect on human SIRT-1 of Resveravine and pure trans-resveratrol. Only the trans-resveratrol form of the molecule promotes normal activation of the mammalian SIRT-1 gene in vitro test. Resveravine was more than eight times more likely to promote SIRT-1 activity than pure trans-resveratrol, showing that Resveravine is more efficient than resveratrol in promoting the normal activity of SIRT-1. Therefore, while the specific mechanisms of SIRT-1 and resveratrol are still unclear, the studies show that SIRT-1 is essential in lifespan extension and health improvement, and resveratrol promotes SIRT-1 activity.*

Studies in numerous species have demonstrated that reduction of calories 30 to 50 percent below ad libitium levels of a nutritious diet can promote a longer lifespan, improve overall health, promote normal stress resistance and decelerate functional decline. Studies showed that, SIRT-1 activates a critical component of calorie restriction in mammals, and promotes fat mobilization in adipocytes by repressing PPAR (test conducted on mice). Because healthy fat levels have been shown to promote a longer murine lifespan, it is suggested that calorie restriction could be connected to SIRT-1 and life extension in mammals.

As an alternative strategy, new research has focused on the development of calorie restriction mimetics, compounds that mimic the effect of calorie restriction by targeting metabolic and stress response pathways affected by calorie restriction, but without restricting caloric intake. Resveratrol has been suggested as a potential calorie restriction mimetic.  

Supplementing mice with resveratrol significantly increases their aerobic capacity. By promoting healthy SIRT-1 activity, resveratrol promotes healthy mitochondrial function and supports energy expenditure, thereby promoting healthy weight. In vivo test conducted on mice on a high-calorie diet, resveratrol shifts the physiology of middle-aged mice on a high-calorie diet towards that of mice on a standard diet and promotes their overall health.  

BioVin® Advanced (French Red Wine Extract with 5% resveratrol): 200 mg

Red wine extract containing oligomeric proanthocyanins (OPCs), known to be extremely effective in supporting cardiovascular health by supporting normal blood circulation, strengthening blood vessels, and promoting normal platelet activity. BioVin Advanced provides OPCs and additional Resveratrol. The red wine grape contains two main constituents shown to be of significant antioxidant value: red wine polyphenols (flavonoids) and trans-resveratrol (mentioned above). Oligomeric proanthocyanins are flavonoid complexes that act as super potent antioxidants in the human body. BioVin Advanced combines the antioxidant properties of OPCs with trans-resveratrol to promote phase 2 metabolizing enzymes, which are involved in the detoxification of the body’s cells, promoting apoptosis (programmed cell death) in unhealthy cells, promoting healthy cholesterol levels, and general free-radical scavenging properties.*

VitaBlue® Wild Blueberry Extract (12.5% anthocyanins): 50 mg

Blueberries rank highest among many fruits and vegetables for ORAC activity and contain 25-30 different types of anthocyanins. Anthocyanin gives blueberries (and other fruits) their rich blue and red coloring, and is a powerful flavonoid antioxidant. The mechanism of action surrounding anthocyanins has been studied at the molecular level, demonstrating effects such as the promotion of healthy cells and apoptosis (programmed cell death). Blueberries provide large amounts of chlorogenic acid, which is thought to be important in promoting cellular health. VitaBlue Wild Blueberry Extract supports the body’s COX-2 inhibitors and provides powerful antioxidants in much higher quantities than fresh blueberries, and show to be effective in promoting cardiovascular health, contributing to normal cell cycle traverse, and maintaining overall cellular health.

 

 

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Orlampa Enterprises, Inc. specializes in helping individuals lose sickness and find wellness.  

Orlampa Enterprises also helps health care professionals implement holistic wellness programs into their existing practice with the goal to educate both the health care provider and the patient. The programs, which provide the health care professional with a substantial additional income stream in this ever changing medical marketplace, allow the patient to achieve true wellness instead of receiving a traditional treatment for symptoms.

Orlampa Enterprises is an internet based product broker specializing in personalized health and wellness related services. Orlampa Enterprises is primed to continue its growth by duplicating its successful business model of educating, training, and developing entrepreneurial leaders as business partners. As an Unfranchise™ business owner, Orlampa Enterprises, proudly utilizes highly researched products including nutraMetrix® nutritional supplements. 

 Orlampa Enterprises' motto is "Eat well, exercise, and supplement intelligently."

Contact Beth at bb@orlampa.com or 727.492.8212 for more information about nutraMetrix® partnership opportunities available.