Primary Benefits of nutraMetrix Isotonix® Magnesium*:
- Promotes head comfort
- Promotes optimal muscle health and comfort
- Helps maintain normal blood sugar levels
- Supports a healthy sleep quality
- Helps maintain normal blood pressure
- Supports cardiovascular health
- Promotes cognitive health
- Supports bone health
- Helps the body maintain a healthy (or sufficient or proper) level of magnesium, combating magnesium deficiency
Key Ingredients Found in nutraMetrix Isotonix® Magnesium*:
Magnesium (Citrate & Glycinate) 400 mg Magnesium
is a component of the mineralized part of bone and supports the normal
metabolism of potassium and calcium in adults. It helps maintain normal
levels of potassium, phosphorus, calcium, adrenaline and insulin. It
also promotes the normal mobilization of calcium, transporting it inside
the cell for further utilization. It plays a key role in supporting the
normal functioning of muscle and nervous tissue. Magnesium promotes the
normal synthesis of all proteins, nucleic acids, nucleotides, cyclic
adenosine monophosphate, lipids and carbohydrates.
Magnesium is
required for release of energy and it promotes the normal regulation of
body temperature and proper nerve function, it helps the body handle
stress, and it promotes a healthy metabolism. Magnesium works together
with calcium to help maintain the normal regulation of the heart and
blood pressure. Importantly, magnesium also supports the body’s ability
to build healthy bones and teeth, and promotes proper muscle
development. It works together with calcium and vitamin D to help keep
bones strong. Magnesium also promotes cardiovascular health by
supporting normal platelet activity and helping to maintain normal
cholesterol levels.
Potassium (Bicarbonate) 150 mg Potassium
is an electrolyte stored in the muscles. Foods rich in potassium
include bananas, oranges, cantaloupe, avocado, raw spinach, cabbage and
celery. Potassium is an essential macromineral that helps maintain fluid
balance in the body. It also supports a wide variety of biochemical and
physiological processes. Among other things, potassium supports the
normal transmission of nerve impulses, contraction of cardiac, skeletal
and smooth muscle, synthesis of nucleic acids, maintenance of
intracellular tonicity and maintenance of normal blood pressure.
In
1928, it was first suggested that high potassium intake could help
maintain cardiovascular health. Potassium supports normal muscle
relaxation and insulin release. It also promotes glycogen and protein
synthesis. Potassium is an electrolyte that promotes normal heartbeat.
Potassium supports the body’s ability to regulate water balance, recover
from exercise and eliminate wastes.
Scientific Support for nutraMetrix Isotonix® Magnesium*:
- Houston
M. The role of magnesium in hypertension and cardiovascular disease. J
Clin Hypertens (Greenwich). 13(11):843-7, 2011. Review.
- Institute
of Medicine. Food and Nutrition Board. Dietary Reference Intakes:
Calcium, Phosphorus, Magnesium, Vitamin D and Fluoride. National Academy
Press. Washington, DC, 1999.
- Appel LJ. Nonpharmacologic therapies that reduce blood pressure: A fresh perspective. Clin Cardiol. 22:1111-5, 1999.
- Svetkey
LP et al. Effects of dietary patterns on blood pressure: Subgroup
analysis of the Dietary Approaches to Stop Hypertension (DASH)
randomized clinical trial. Arch Intern Med. 159:285-93, 1999.
- Peacock
JM et al. Relationship of serum and dietary magnesium to incident
hypertension: the Atherosclerosis Risk in Communities (ARIC) Study.
Annals of Epidemiology. 9:159-65, 1999.
- Widman
L et al. The dose-dependent reduction in blood pressure through
administration of magnesium. A double blind placebo controlled
cross-over study. Am J Hypertens. 6:41-5, 1993.
- Altura
BM and Altura BT. Magnesium and cardiovascular biology: An important
link between cardiovascular risk factors and atherogenesis. Cell Mol
Biol Res. 41:347-59, 1995.
- Wester PO. Magnesium. Am J Clin Nutr. 45:1305-12, 1987.
- Saris
NE, Mervaala E, et al. Magnesium: an update on physiological, clinical,
and analytical aspects. Clinica Chimica Acta. 294:1-26, 2000.
- Sanjuliani
AF et al. Effects of magnesium on blood pressure and intracellular ion
levels of Brazilian hypertensive patients. Int J Cardiol. 56:177-83,
1996.
- Shechter M et al.
Effects of oral magnesium therapy on exercise tolerance,
exercise-induced chest pain, and quality of life in patients with
coronary artery disease. Am J Cardiol. 91:517-21, 2003.
- Jee
SH et al. The effect of magnesium supplementation on blood pressure: a
meta-analysis of randomized clinical trials. Am J Hypertens. 15:691-6,
2002.
- Preuss HG, Gondal
JA, Lieberman S. Association of macronutrients and energy intake with
hypertension. J Am Coll Nutr. 15:21-35, 1996.
- Shechter
M et al. Oral magnesium therapy improves endothelial function in
patients with coronary artery disease. Circulation.102:2353-58, 2000.
- Khosh, F. Natural approach to hypertension. Alternative Medicine Review. 6(6), 2001.
- Vormann J. Magnesium: nutrition and metabolism. Molecular Aspects of Medicine. 24:27-37, 2003.
- Rude KR. Magnesium metabolism and deficiency. Endocrinol Metab Clin North Am. 22:377-95, 1993.
- Kobrin SM and Goldfarb S. Magnesium Deficiency. Semin Nephrol.10:525-35, 1990.
- Lopez-Ridaura R et al. Magnesium intake and risk of type 2 diabetes in men and women. Diabetes Care. 27:134-40, 2004.
- Paolisso G et al. Daily magnesium supplements improve glucose handling in elderly subjects. Am J Clin Nutr. 55:1161-7, 1992.
- Rodriguez-Moran
M and Guerrero-Romero F. Oral magnesium supplementation improves
insulin sensitivity and metabolic control in type 2 diabetic subjects.
Diabetes Care. 26:1147-52, 2003.
- Kobrin SM and Goldfarb S. Magnesium Deficiency. Semin Nephrol. 10:525-35, 1990.
- Meyer KA et al. Carbohydrates, dietary fiber, and incident type 2 diabetes in older women. Am J Clin Nutr. 71:921-30, 2000.
- Song
Y et al. Dietary magnesium intake in relation to plasma insulin levels
and risk of type 2 diabetes in women. Diabetes Care. 27:59-65, 2004.
- Huerta
MG, Roemmich JN, Kington ML, et al. Magnesium deficiency is associated
with insulin resistance in obese children. Diabetes Care. 28:1175-81,
2005.
- Sales CH et al.
Influence of magnesium status and magnesium intake on the blood glucose
control in patients with type 2 diabetes. Clin Nutr. 30(3):359-64, 2011.
- Trauninger, A., et al. Oral magnesium load test in patients with migraine. Headache. 42(4):114-119, 2002.
- Sinclair,
S., et al. Migraine headaches: nutritional, botanical and other
alternative approaches. Alternative Medicine Review. 4(2):86-95, 1999.
- Maizels,
M., et al. A combination of riboflavin, magnesium, and feverfew for
migraine prophylaxis: a randomized trial. Headache. 44(9):885-90, 2004.
- Woolhouse,
M. Migraine and tension headache--a complementary and alternative
medicine approach. Aust Fam Physician. 34(8):647-51, 2005. Review.
- Brown
R. and Gerbarg P. Herbs and nutrients in the treatment of depression,
anxiety, insomnia, migraine, and obesity. J Psychiatr Pract. 7(2):75-91,
2001.
- Peikert, A., et
al. Prophylaxis of migraine with oral magnesium: Results from a
prospective, multi-center, placebo-controlled and double-blind
randomized study. Cephalalgia. 16(4):257-63, 1996.
- Mauskop, A., et al. Role of magnesium in the pathogenesis and treatment of migraines. Clin Neurosci. 5(1):24-27, 1998.
- Demirkaya
S et al. A comparative study of magnesium, flunarizine and
amitriptyline in the prophylaxis of migraine. J Headache Pain. 1:179-86,
2000.
- Wang, F., et al.
Oral magnesium oxide prophylaxis of frequent migrainous headache in
children: a randomized, double-blind, placebo-controlled trial.
Headache. 43(6):601-610, 2003.
- Tucker
KL, Hannan MT, Chen H, Cupples LA, Wilson PW, Kiel DP. Potassium,
magnesium, and fruit and vegetable intakes are associated with greater
bone mineral density in elderly men and women. Am J Clin Nutr.
69(4):727-36, 1999.
- Elisaf
M, Milionis H, Siamopoulos K. Hypomagnesemic hypokalemia and
hypocalcemia: Clinical and laboratory characteristics. Mineral
Electrolyte Metab. 23:105-12, 1997.
- Stendig-Lindberg
G et al. Trabecular bone density in a two year controlled trial of
peroral magnesium in osteoporosis. Magnes Res. 6:155-63, 1993.
- Tranquilli
AL et al. Calcium, phosphorus and magnesium intakes correlate with bone
mineral content in postmenopausal women. Gynecol Endocrinol. 8:55-8,
1994.
- Institute of
Medicine. Food and Nutrition Board. Dietary Reference Intakes: Calcium,
Phosphorus, Magnesium, Vitamin D and Fluoride. National Academy Press.
Washington, DC, 1999.
- New
SA et al. Nutritional influences on bone mineral density: a
cross-sectional study in premenopausal women. Am J Clin Nutr. 65:1831-9,
1997.
- Gruber H et al.
Magnesium deficiency: effect on bone mineral density in the mouse
appendicular skeleton. BMC Musculoskelet Disord. 4(1):7, 2003.
- Ryder
K et al. Magnesium intake from food and supplements is associated with
bone mineral density in healthy older white subjects. J Am Geriatr
Soc. 53(11):1875-1880, 2005.
- Rude R et al. Magnesium deficiency and osteoporosis: animal and human observations. J Nutr Biochem. 15(12):710-716, 2004.
- Bilbey, D.L. J., et al. Muscle cramps and magnesium deficiency: case reports. Can Fam Physician. 42:1348-51, 1996.
- Dahle,
L. O., et al. The effect of oral magnesium substitution on
pregnancy-induced leg cramps. Am J Obstet Gynecol. 173(1):175-180,
1995.
- Roffe, C., et al.
Randomised, cross-over, placebo controlled trial of magnesium citrate in
the treatment of chronic persistent leg cramps. Med Sci Monit.
8(5):CR326-CR330, 2002.
- Saris,
N.-E. L., et al. Magnesium: an update on physiological, clinical and
analytical aspects. Clinica Chimica Acta. 294:1-26, 2000.
- Yu-Yahiro, J. A. Electrolytes and their relationship to normal and abnormal muscle function. Orthop Nurs. 13(5):38-40, 1994.
- Brilla,
L. R., et al. Effect of magnesium supplementation on strength training
in humans. J Am Coll Nutr. 11(3):326-329, 1992.
- Caddell
JL. Magnesium deficiency promotes muscle weakness, contributing to the
risk of sudden infant death (SIDS) in infants sleeping prone. Magnes
Res. 14(1-2):39-50, 2001. Review.
- Hornyak
M et al. Magnesium therapy for periodic leg movements-related insomnia
and restless legs syndrome: an open pilot study. Sleep. 21:501-5, 1998.
- Popoviciu
L et al. Clinical, EEG, electromyographic and polysomnographic studies
in restless legs syndrome caused by magnesium deficiency (abstract). Rom
J Neurol Psychiatry. 31:55-61, 1993.
- Tanabe,
K., et al. Erythrocyte magnesium and prostaglandin dynamics in chronic
sleep deprivation. Clin Cardiol. 20(3):265-268, 1997.
- Tanabe,
K., et al. Efficacy of oral magnesium administration on decreased
exercise tolerance in a state of chronic sleep deprivation. Jpn Circ
J. 62(5):341-346, 1998.
- Chollet
D et al. Blood and brain magnesium in inbred mice and their
correlation with sleep quality. Am J Physiol Regul Integr Comp
Physiol. 279(6):R2173-8, 2000.
- Barker J. Insomnia options; natural medicine choices. Townsend Letter for Doctors and Patients. April 2004.
- Sato-Mito
N et al. The midpoint of sleep is associated with dietary intake and
dietary behavior among young Japanese women. Sleep Med. 12(3):289-94,
2011.
- Corsonello A et al.
Serum magnesium levels and cognitive impairment in hospitalized
hypertensive patients. Magnes Res. 14(4):273-82, 2001.
- Saris,
N.-E. L., et al. Magnesium: an update on physiological, clinical and
analytical aspects. Clinica Chimica Acta. 294:1-26, 2000.
- Huskisson
E et al. The influence of micronutrients on cognitive function and
performance. J Int Med Res. 35(1):1-19, 2007. Review.
- Guran T et al. Cognitive and psychosocial development in children with familial hypomagnesaemia. Magnes Res. 24(1):7-12, 2011.
- Inna Slutsky et al. Enhancement of Learning and Memory by Elevating Brain Magnesium. Neuron. 65(2):165-77, 2010.
What Makes nutraMetrix Isotonix® Magnesium Unique?
Magnesium
is the fourth most abundant mineral in the body and supports more than
300 enzyme systems. It is required for energy, regulation of the body
temperature, nerve function, adaptation to stress, metabolism and much
more.
One of the main mechanisms of magnesium in the body is its
support of normal protein synthesis. Normal protein synthesis relies on
optimal magnesium concentrations, as magnesium supports the normal
delivery to the building blocks of life – our DNA – of signals that
trigger the expression of amino acids. In other words, this process
supports the body’s normal ability to "make" proteins.
The
recommended daily value for adults is 400 mg of magnesium. However,
average daily intakes are much less. A study published in the Journal of Nutrition
found that most U.S. adults – especially those over the age of 30 –
were receiving, on average, approximately 290 mg of magnesium daily.
That study also showed that dietary intake is particularly low among
women.
Unfortunately, inadequate levels of magnesium have been
linked to poorer concentration, memory and cognitive function and muscle
discomfort. Sleep quality is associated with higher levels of magnesium
and when these levels are low, sleep quality may suffer.
nutraMetrix
Isotonix Magnesium provides the body with 100 percent of the
recommended daily value of magnesium in a highly-bioavailable formula.
Thanks to its unique formula, which includes two different types of
magnesium to increase its absorption by the body, Isotonix Magnesium
helps maintain normal blood pressure and supports bone health and sleep
quality, while promoting head comfort and optimal muscle health.
Frequently Asked Questions about nutraMetrix Isotonix® Magnesium*:
What benefits does magnesium provide the body? With
its involvement in supporting over 300 enzyme reactions, magnesium
plays roles in many aspects of health. It is required for normal energy
release, regulation of the body temperature, nerve function, adaptation
to stress and metabolism.
With
regards to bone health, it is an important component of the mineralized
part of bone and supports the normal metabolism of calcium and
potassium in adults. Magnesium works together with calcium and vitamin D
to help keep bones strong and support bone mineral density.
Magnesium
also supports muscle development and movement and the transmission of
nerve impulses to the muscles. Studies clearly demonstrate the effects
of supplemental magnesium on muscular health. Adequate magnesium levels
are also important for cardiovascular health.
Studies show
magnesium supports a regular heartbeat, thus promoting a healthy heart.
Additionally, magnesium helps maintain normal blood pressure. Magnesium
helps maintain normal blood pressure.
Magnesium supports normal
protein synthesis. As such, there is evidence that magnesium helps
maintain normal blood sugar levels.
How much magnesium should I be getting, and why do I need a magnesium supplement versus getting it from my normal diet? The
recommended daily intake for adults, established by the Institute of
Medicine of the National Academy of Sciences, states that adult males
between the ages of 19 and 30 should be receiving 400 mg of magnesium
daily. Adult females of the same age should receive 310 mg daily. For
older males, the recommendation is 420 mg daily, while older females
should consume 320 mg daily.
Daily lifestyle factors and poor
dietary choices adversely affect the amount of magnesium we are
ingesting. Foods rich in magnesium include whole grains, nuts and green
vegetables, which are potent sources of magnesium because of their
chlorophyll content. Meats, starches, dairy products and refined and
processed foods – which make up a large portion of the typical diet in
today’s society – contain low amounts of magnesium. High-fat diets not
only provide lesser amounts of magnesium, but studies have shown that
such a diet might even cause less magnesium to be absorbed by the body.
Even
with a proper, balanced diet, the amount of nutrients in foods today
vastly differs from those of even a generation ago. In addition, food
preparation methods may decrease the magnesium content of food. For
these reasons, it is important to help balance our diets with
nutritional supplements that can provide additional nutritional
assistance.
Why were these forms of magnesium (citrate and glycinate) chosen? Both
of these forms of magnesium were carefully chosen based on the latest
scientific rationale, as they have been shown to have excellent oral
absorption rates and work well within the Isotonix® delivery system.
What is the Isotonix delivery system, and how does it work? Isotonic,
which means “same pressure,” bears the same chemical resemblance of the
body’s blood, plasma and tears. All fluids in the body have a certain
concentration, referred to as osmotic pressure. The body’s common
osmotic pressure, which is isotonic, allows a consistent maintenance of
body tissues. In order for a substance to be absorbed and used in the
body’s metabolism, it must be transported in an isotonic state.
When
an isotonic substance enters the body, it will be absorbed into the
bloodstream rapidly. Isotonix dietary supplements are delivered in an
isotonic solution, allowing nutrients to pass directly into the small
intestine and be rapidly absorbed into the bloodstream. With Isotonix
products, little nutritive value is lost, making the absorption of
nutrients highly efficient while delivering maximum results.
Does this product need to be taken on an empty stomach? Yes. For maximum absorption, the product should be taken on an empty stomach.
Is there anyone who should not take this product? Anyone
who has an ongoing medical condition, is pregnant or breastfeeding, or
is taking prescription medication should speak with their healthcare
provider before taking this product. Also, magnesium should be used
cautiously by those with reduced kidney function.
What other health & nutrition products would complement Isotonix Magnesium? The
benefits of nutraMetrix Isotonix Magnesium are complemented by nutraMetrix Isotonix OPC-3®, nutraMetrix Isotonix Calcium Plus,
nutraMetrix Isotonix Vitamin D with K2 and Heart Health™ Omega III Fish
Oil with Vitamin E.
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Enterprises, Inc. specializes in helping individuals, groups, & companies
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also helps health care professionals implement holistic wellness programs into
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Orlampa Enterprises' motto is "Eat well, exercise, and
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