| Vitamin D deficiency linked to serious illnesses | ||
Although Vitamin D is commonly called the "sunshine" vitamin, it is actually a steroid hormone, not an essential dietary vitamin. An essential dietary vitamin is something that an organism cannot produce on its own and must get from a dietary source. Vitamin D is found in few dietary sources, however. For most people, sunlight exposure is the primary source of vitamin D, other than supplements. Vitamin D was originally thought to play a role only in the mineralization of bones and teeth by maintaining the correct phosphorous/calcium ratio. Over time, though, research has linked low vitamin D levels with other problems, such as obesity, diabetes, cardiovascular disease, autoimmune disease, osteoporosis and cancer. According to a report released by the CDC in 2006, nearly a quarter of the U.S. population is deficient in vitamin D. One percent of the population has Vitamin D levels low enough to be considered imminently harmful. There are many theories as to why this is happening. One is that Americans today do not spend as much time outdoors as they did in generations past. In Arizona, our 300 days of sunshine every year provides plenty of opportunity to soak up the sun. Those who do get plenty of sun, however, tend to slather on the sunscreen for protection against skin cancer. The problem is, sunscreen inhibits UVB rays (the rays responsible for suntans) from penetrating the skin. Without those UVB rays, vitamin D cannot be naturally produced. Other factors also impact upon how much UVB rays reach the skin. Factors such as time of day, the season, the altitude, the latitude and more make a difference in the natural production of Vitamin D. Vitamin D levels can become especially depleted during the winter months when we stay inside more and the sun is not as intense. A growing amount of research links depression to Vitamin D levels but results are mixed. Research does seem to show a link between low levels of vitamin D and symptoms of depression. However, it's unclear whether low vitamin D levels cause depression, or whether depression results in low vitamin D levels. Here are a few important things to note: • The healing properties of natural sunlight cannot penetrate glass. You cannot reap the Vitamin D benefits of sunshine while sitting inside your home or car. You must go outside. • Darker-skinned individuals can require as much as 25 times more exposure time as a light skinned person to get the same amount of vitamin D. • Unless your body has sufficient levels of vitamin D, it cannot absorb calcium no matter how much calcium you take. • If you are diagnosed with a vitamin D deficiency, it will take months of adequate sunlight and/or supplements to return your body to normal levels. • Kidney disease or liver damage will hinder your body's ability to activate vitamin D when needed. Have your vitamin D level checked by a simple blood test. High quality Vitamin D supplements can be found at www.opc411.com. 
Despite the fact that there are many vitamin D supplements to choose from, Isotonix Vitamin D with K2 proves that all supplements are not created equal. By being the first of its kind to combine vitamin D with vitamin K2 in an isotonic form, this product supports vascular health and calcium utilization. By enhancing vitamin D's role in bone health, heart health and immune support, the addition of vitamin K also helps to support normal calcium absorption and the promotion of healthy arteries.
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Showing posts with label vitamin d deficiency. Show all posts
Showing posts with label vitamin d deficiency. Show all posts
Monday, July 21, 2014
Vitamin D deficiency linked to serious illnesses
Thursday, January 23, 2014
Vitamin D and fertility in men and women
Vitamin D and fertility in men and women
Dr John Cannell
Every year, billions are spent in fertility clinics; the result of which is often in vitro fertilization (IVF). About 5 years ago, I began receiving emails from a nurse practitioner in Indiana who works in a fertility clinic. Her experience was dramatic; 5,000 IU/day for both the man and woman frequently resulted in a healthy baby. However, her last email to me was quite sad, she was in danger of losing her job as her boss, a gynecologist, was losing money due to vitamin D. He ordered her to stop advocating it or lose her job.
Today, the Daily Mail and several other newspapers reviewed a lengthy article in The European Journal of Endocrinology that concluded, “Given the high prevalence of infertility as well as vitamin D insufficiency in otherwise healthy young women and men and the possible role of vitamin D in human reproduction, research might lead to new therapeutic approaches such as vitamin D supplementation in the treatment of female and male reproductive disorders.”
Critical to this carefully caged advice is the fact that men need help as frequently as the women do. “Population-based studies found that in 30-40% of infertile couples the underlying cause is the male factor. In this context it should be mentioned that the overall semen quality of men is decreasing, which might partly be explained by environmental factors. Indeed, as much as 20% of young men have sperm concentration below the WHO recommendation level and 40% present with sperm concentrations below a level that is considered optimal for fertility.” Pretty amazing, especially when you realize these men have normal testosterone levels but that vitamin D levels are steadily decreasing.
Elisabeth Lerchbaum and Barbara Obermayer-Pietsch Vitamin D and fertility-a systematic review. European Journal of Endocrinology January 30, 2012
The authors go onto say, “In northern countries, where a strong seasonal contrast in luminosity (sunshine intensity) exists, the conception rate is decreased during the dark winter months, whereas a peak in conception rate during summer leading to a maximum in birth rate in spring has been observed. Moreover, ovulation rates and endometrial receptivity seem to be reduced during long dark winters in northern countries.”
While no direct studies exist of vitamin D levels and fertility per se, the authors report, “In a study among 84 infertile women undergoing in vitro fertilization, women with higher levels of 25(OH)D in serum and follicular fluid were significantly more likely to achieve clinical pregnancy following in vitro fertilization . . .”
If you don’t want to work your way through the entire 42 page paper, read the excellent synopsis in the Daily Mail below.
Carey T. Sunny break may be alternative to in vitro fertilization: How the sunshine vitamin can help boost fertility. Daily Mail Online, January 30, 2012.
The takeaway message is the same as always, a message so common I should just start saying “ditto.” If you want to get pregnant, make sure you and your partner take 5,000 IU/day. If you don’t want to get pregnant, make sure you and your partner are on 5,000 IU/day plus a reliable method of birth control. I take no responsibility for surprise pregnancies.
Every year, billions are spent in fertility clinics; the result of which is often in vitro fertilization (IVF). About 5 years ago, I began receiving emails from a nurse practitioner in Indiana who works in a fertility clinic. Her experience was dramatic; 5,000 IU/day for both the man and woman frequently resulted in a healthy baby. However, her last email to me was quite sad, she was in danger of losing her job as her boss, a gynecologist, was losing money due to vitamin D. He ordered her to stop advocating it or lose her job.
Today, the Daily Mail and several other newspapers reviewed a lengthy article in The European Journal of Endocrinology that concluded, “Given the high prevalence of infertility as well as vitamin D insufficiency in otherwise healthy young women and men and the possible role of vitamin D in human reproduction, research might lead to new therapeutic approaches such as vitamin D supplementation in the treatment of female and male reproductive disorders.”
Critical to this carefully caged advice is the fact that men need help as frequently as the women do. “Population-based studies found that in 30-40% of infertile couples the underlying cause is the male factor. In this context it should be mentioned that the overall semen quality of men is decreasing, which might partly be explained by environmental factors. Indeed, as much as 20% of young men have sperm concentration below the WHO recommendation level and 40% present with sperm concentrations below a level that is considered optimal for fertility.” Pretty amazing, especially when you realize these men have normal testosterone levels but that vitamin D levels are steadily decreasing.
Elisabeth Lerchbaum and Barbara Obermayer-Pietsch Vitamin D and fertility-a systematic review. European Journal of Endocrinology January 30, 2012
The authors go onto say, “In northern countries, where a strong seasonal contrast in luminosity (sunshine intensity) exists, the conception rate is decreased during the dark winter months, whereas a peak in conception rate during summer leading to a maximum in birth rate in spring has been observed. Moreover, ovulation rates and endometrial receptivity seem to be reduced during long dark winters in northern countries.”
While no direct studies exist of vitamin D levels and fertility per se, the authors report, “In a study among 84 infertile women undergoing in vitro fertilization, women with higher levels of 25(OH)D in serum and follicular fluid were significantly more likely to achieve clinical pregnancy following in vitro fertilization . . .”
If you don’t want to work your way through the entire 42 page paper, read the excellent synopsis in the Daily Mail below.
Carey T. Sunny break may be alternative to in vitro fertilization: How the sunshine vitamin can help boost fertility. Daily Mail Online, January 30, 2012.
The takeaway message is the same as always, a message so common I should just start saying “ditto.” If you want to get pregnant, make sure you and your partner take 5,000 IU/day. If you don’t want to get pregnant, make sure you and your partner are on 5,000 IU/day plus a reliable method of birth control. I take no responsibility for surprise pregnancies.
****
nutraMetrix Isotonix® Vitamin D with K2
nutraMetrix Isotonix Vitamin D with K2 contains vitamin D3, the metabolically active form of vitamin D, along with vitamin K2, a form of vitamin K which supports vascular health and calcium utilization. Vitamin D plays an important role in bone health, heart health and immune support, while working with vitamin K to support normal absorption of calcium and promote healthy arteries. nutraMetrix Isotonix Vitamin D is the first of its kind to deliver both of these powerful vitamins with isotonic delivery.
Vitamin K is included in nutraMetrix Isotonix Vitamin D with K2 because of its unique partnership with vitamin D. Vitamins K and D work together to support calcium absorption and utilization. Vitamin K supports the normal delivery of calcium to the bones and promotes healthy arteries.
At least two naturally-occurring forms of vitamin K have been identified and are known as K1 and K2. While there are many similarities between these two forms of vitamin K, they are distinguished by their important differences. The most significant difference between K1 and K2 is their chemical structure which results in different pharmacokinetic properties. Vitamin K1 is retained primarily in the liver where, at high doses, it may interfere with the action of warfarin and other anticoagulant medications.
Vitamin K2 has a different mechanism of action. It is transported primarily to bones and blood vessels. Vitamin K2 helps to maintain bone mass, support calcium utilization and promote elasticity of blood vessels.
Some studies have concluded that vitamin K2 does not interfere with anticoagulant medications.* However, most products containing vitamin K (including K1 and/or K2) warn users taking anticoagulants not to take the product. If you are currently taking warfarin or another anticoagulant medication, you should consult your physician before taking any product containing vitamin K1 or K2.
Isotonix dietary supplements are delivered in an isotonic solution. This means that the body has less work to do to obtain maximum absorption of the nutrients. The isotonic state of the suspension allows nutrients to pass directly into the small intestine and rapidly absorb into the bloodstream. With Isotonix products, little nutritive value is lost, making the absorption of nutrients highly efficient while delivering maximum results.
Key Ingredients Found in nutraMetrix Isotonix® Vitamin D with K2:
Vitamin D3 (Cholecalciferol) 5000 IU
Vitamin D is a fat-soluble vitamin that is found in some foods and endogenously produced when sunlight strikes the skin and activates vitamin D synthesis. Vitamin D promotes the efficient intestinal absorption of calcium, primarily in the duodenum and jejunum by supporting the synthesis of calcium-binding proteins to promote normal calcium absorption and retention. Vitamin D also promotes the normal formation of bone and normal bone growth and bone remodeling by osteoblasts and osteoclasts. Vitamin D deficiency can be caused by factors such as lack of exposure to sunlight, reduced skin synthesis of vitamin D, lower dietary intake, impaired intestinal absorption and reduced metabolism to active forms of vitamin D by the kidneys, all of which increase with aging. Deficiency has been linked to numerous health concerns, and insufficient levels of this vitamin are associated with weak bones and muscle weakness. In addition to promoting strong bones, vitamin D also has other roles in health, including supporting the body’s normal modulation of neuromuscular function and immune function. Vitamin D has been shown to support immune-modulation, and it is thought that supplementation promotes immune health by promoting the body’s normal regulation of T-cell function. In reference to cellular health, vitamin D supports the modulation of many genes that are responsible for encoding proteins that regulate normal cell cycle activity. Vitamin D levels have been strongly correlated to healthy cells. Lastly, through its interaction with VDR (vitamin D receptor), vitamin D supports the healthy expression of the gene encoding renin, thus helping to maintain healthy blood pressure.*
Vitamin D is a fat-soluble vitamin that is found in some foods and endogenously produced when sunlight strikes the skin and activates vitamin D synthesis. Vitamin D promotes the efficient intestinal absorption of calcium, primarily in the duodenum and jejunum by supporting the synthesis of calcium-binding proteins to promote normal calcium absorption and retention. Vitamin D also promotes the normal formation of bone and normal bone growth and bone remodeling by osteoblasts and osteoclasts. Vitamin D deficiency can be caused by factors such as lack of exposure to sunlight, reduced skin synthesis of vitamin D, lower dietary intake, impaired intestinal absorption and reduced metabolism to active forms of vitamin D by the kidneys, all of which increase with aging. Deficiency has been linked to numerous health concerns, and insufficient levels of this vitamin are associated with weak bones and muscle weakness. In addition to promoting strong bones, vitamin D also has other roles in health, including supporting the body’s normal modulation of neuromuscular function and immune function. Vitamin D has been shown to support immune-modulation, and it is thought that supplementation promotes immune health by promoting the body’s normal regulation of T-cell function. In reference to cellular health, vitamin D supports the modulation of many genes that are responsible for encoding proteins that regulate normal cell cycle activity. Vitamin D levels have been strongly correlated to healthy cells. Lastly, through its interaction with VDR (vitamin D receptor), vitamin D supports the healthy expression of the gene encoding renin, thus helping to maintain healthy blood pressure.*
Vitamin K2 45 mcg
Vitamin K is a fat-soluble vitamin found in meat, eggs, dairy and natto. Although a fat-soluble vitamin, the body stores very little K2, and its stores are rapidly depleted without regular dietary intake. Natural vitamin K2, also known as menaquinone-7 (MK-7), is the most bioavailable form of K2 and has the longest half-life in the blood of any form of vitamin K. The Japanese soy food natto is particularly rich in menaquinone-7 (MK-7). Studies of natto consumption in Japan have linked menaquinone-7 to bone and cardiovascular health. The correlation of vitamin K to cardiovascular and bone health directly focuses on supporting proper calcium utilization, whereby adequate metabolism of calcium supports arterial and bone health. This is often referred to as the calcium paradox. The calcium paradox is explained simply as getting calcium in the right place (i.e., into the bone structures instead of the arterial vessel walls.) These events are dependent upon the synthesis of the vitamin K-dependent proteins osteocalcin and matrix Gla protein in a process called carboxylation. The carboxylation of these proteins is a post-translational step; that is, osteocalcin and matrix Gla protein are translated from their respective messenger RNA and then modified by enzymes to the active forms. These carboxylated forms support the healthy binding and releasing of calcium. This reaction is essential for optimal and healthy utilization of calcium. Vitamin K2 promotes the synthesis of proteins involved with calcium utilization, thereby supporting bone retention and arterial health. While Vitamin D supports the healthy regulation and synthesis of osteocalcin, the mineral-binding capacity of this protein requires vitamin K-dependent carboxylation and is thought to be related to bone mineralization. Gas6 is a vitamin K-dependent protein found throughout the nervous system, as well in the heart, lungs, stomach, kidneys and cartilage. Although the exact mechanism of its action has not been determined, Gas6 appears to be a cellular growth regulator involved in cellular activities such as cell adhesion, cell proliferation and protection against apoptosis.
Vitamin K is a fat-soluble vitamin found in meat, eggs, dairy and natto. Although a fat-soluble vitamin, the body stores very little K2, and its stores are rapidly depleted without regular dietary intake. Natural vitamin K2, also known as menaquinone-7 (MK-7), is the most bioavailable form of K2 and has the longest half-life in the blood of any form of vitamin K. The Japanese soy food natto is particularly rich in menaquinone-7 (MK-7). Studies of natto consumption in Japan have linked menaquinone-7 to bone and cardiovascular health. The correlation of vitamin K to cardiovascular and bone health directly focuses on supporting proper calcium utilization, whereby adequate metabolism of calcium supports arterial and bone health. This is often referred to as the calcium paradox. The calcium paradox is explained simply as getting calcium in the right place (i.e., into the bone structures instead of the arterial vessel walls.) These events are dependent upon the synthesis of the vitamin K-dependent proteins osteocalcin and matrix Gla protein in a process called carboxylation. The carboxylation of these proteins is a post-translational step; that is, osteocalcin and matrix Gla protein are translated from their respective messenger RNA and then modified by enzymes to the active forms. These carboxylated forms support the healthy binding and releasing of calcium. This reaction is essential for optimal and healthy utilization of calcium. Vitamin K2 promotes the synthesis of proteins involved with calcium utilization, thereby supporting bone retention and arterial health. While Vitamin D supports the healthy regulation and synthesis of osteocalcin, the mineral-binding capacity of this protein requires vitamin K-dependent carboxylation and is thought to be related to bone mineralization. Gas6 is a vitamin K-dependent protein found throughout the nervous system, as well in the heart, lungs, stomach, kidneys and cartilage. Although the exact mechanism of its action has not been determined, Gas6 appears to be a cellular growth regulator involved in cellular activities such as cell adhesion, cell proliferation and protection against apoptosis.
Orlampa Health
www.orlampahealth.com
727.492.8212
Vitamin D Can Effectively Treat Fibromyalgia
Vitamin D Can Effectively Treat Fibromyalgia
Reviewed by John M. Grohol, Psy.D. on January 20, 2014
New research suggests vitamin D supplements can reduce pain and may be a cost-effective alternative, or an adjunct to other treatment, for individuals with fibromyalgia syndrome (FMS).
The supplementation is helpful for fibromyalgia patients suffering from low vitamin D levels, say researchers in the journal PAIN®.
In addition to pain and fatigue, individuals diagnosed with FMS may experience sleep disorders, morning stiffness, poor concentration, and occasionally mild-to-severe mental symptoms such as anxiety or depression.
The condition can have a significant impact on the patient’s quality of life, resulting in loss of employment and/or withdrawal from social life.
There is no cure, and no treatment will address all of the symptoms, but some symptoms may be alleviated by physical therapy, cognitive behavioral therapy, temporary drug therapy (such as amitriptyline, duloxetine, or pregabaline) and multimodal therapies.
Calcifediol is a prehormone produced in the liver by the enzyme cholecalciferol (vitamin D3).
Calcifediol is then converted to calcitriol (1,25-(OH)2D3), which is the active form of vitamin D. The concentration of calcifediol in blood is considered the best indicator of vitamin D status.
Researchers hypothesized that vitamin D supplementation would reduce the degree of chronic pain experienced by FMS patients with low levels of calcifediol and also might improve other symptoms.
“Low blood levels of calcifediol are especially common in patients with severe pain and fibromyalgia. But although the role of calcifediol in the perception of chronic pain is a widely discussed subject, we lack clear evidence of the role of vitamin D supplementation in fibromyalgia patients,” said lead investigator Florian Wepner, M.D.
“We therefore set out to determine whether raising the calcifediol levels in these patients would alleviate pain and cause a general improvement in concomitant disorders.”
In a randomized controlled trial, 30 women with FMS with low serum calcifediol levels (below 32ng/ml) were randomized to a treatment or control group.
The goal for the treatment group was to achieve serum calcifediol levels between 32 and 48ng/ml for 20 weeks via oral cholecalciferol supplements.
Serum calcifediol levels were reevaluated after five and 13 weeks, and the dose was reviewed based on the results. The calcifediol levels were measured again 25 weeks after the start of the supplementation, at which time treatment was discontinued, and after a further 24 weeks without supplementation.
Twenty-four weeks after supplementation was stopped, a marked reduction in the level of perceived pain occurred in the treatment group.
Between the first and the 25th week on supplementation, the treatment group improved significantly on a scale of physical role functioning, while the placebo group remained unchanged.
The treatment group also scored significantly better on a Fibromalgia Impact Questionnaire (FIQ) on the question of “morning fatigue.” However, there were no significant alterations in depression or anxiety symptoms.
“We believe that the data presented in the present study are promising. FMS is a very extensive symptom complex that cannot be explained by a vitamin D deficiency alone.
“However, vitamin D supplementation may be regarded as a relatively safe and economical treatment for FMS patients and an extremely cost-effective alternative or adjunct to expensive pharmacological treatment as well as physical, behavioral, and multimodal therapies,” said Wepner.
“Vitamin D levels should be monitored regularly in FMS patients, especially in the winter season, and raised appropriately.”
nutraMetrix Isotonix Vitamin D with K2 contains vitamin D3, the metabolically active form of vitamin D, along with vitamin K2, a form of vitamin K which supports vascular health and calcium utilization. Vitamin D plays an important role in bone health, heart health and immune support, while working with vitamin K to support normal absorption of calcium and promote healthy arteries. nutraMetrix Isotonix Vitamin D is the first of its kind to deliver both of these powerful vitamins with isotonic delivery.
Vitamin K is included in nutraMetrix Isotonix Vitamin D with K2 because of its unique partnership with vitamin D. Vitamins K and D work together to support calcium absorption and utilization. Vitamin K supports the normal delivery of calcium to the bones and promotes healthy arteries.
At least two naturally-occurring forms of vitamin K have been identified and are known as K1 and K2. While there are many similarities between these two forms of vitamin K, they are distinguished by their important differences. The most significant difference between K1 and K2 is their chemical structure which results in different pharmacokinetic properties. Vitamin K1 is retained primarily in the liver where, at high doses, it may interfere with the action of warfarin and other anticoagulant medications.
Vitamin K2 has a different mechanism of action. It is transported primarily to bones and blood vessels. Vitamin K2 helps to maintain bone mass, support calcium utilization and promote elasticity of blood vessels.
Some studies have concluded that vitamin K2 does not interfere with anticoagulant medications.* However, most products containing vitamin K (including K1 and/or K2) warn users taking anticoagulants not to take the product. If you are currently taking warfarin or another anticoagulant medication, you should consult your physician before taking any product containing vitamin K1 or K2.
Isotonix dietary supplements are delivered in an isotonic solution. This means that the body has less work to do to obtain maximum absorption of the nutrients. The isotonic state of the suspension allows nutrients to pass directly into the small intestine and rapidly absorb into the bloodstream. With Isotonix products, little nutritive value is lost, making the absorption of nutrients highly efficient while delivering maximum results.
To learn more about Isotonix Vitamin D with K2 or to order, please contact us at:
orlampahealth.com
727.492.8212
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Ask about our Heart Health Month Specials
Friday, November 1, 2013
Vitamin D Day Celebrated, 11/2
Courtesy of FitnessWorld.com
Vitamin D Day, Saturday, Nov. 2, is a day to recognize vitamin D deficiency as a world problem. Researchers agree that at least one third of the world is deficient in vitamin D, and some scientists even think a greater percent of people are deficient in vitamin D. Why are so many people deficient, it's simple really, vitamin D from sun exposure. Now, more than ever, the world's population lives an indoor lifestyle, avoiding the sun daily.
Vitamin D awareness is particularly important this time of year because from around mid-October to mid-March the sun in Canada is not strong enough to stimulate natural vitamin D production. There are more than 100 good reasons to know your vitamin D level and take action to raise them to ideal levels. Most vitamin D experts recommend a vitamin D blood serum level between 100 and 150 nmol/L.
It's an exciting time for the vitamin D community. Doctors are beginning to discover that vitamin D deficiency is a risk factor for many diseases and may make some diseases more severe. They're also discovering that vitamin D can be an important piece in the treatment of some illnesses and diseases.
Supporting Vitamin D Day is easy. Just learn, education, and participate by checking out the website. Then, take a little time to educate your family and friends. Conquering world vitamin D deficiency starts with better awareness on how we get vitamin D and how we can make sure we're getting enough. Share a simple key fact from the link above, something your family and friends may not know about. The more people know, the more we can ensure people are getting enough vitamin D. And finally, participate. The easiest ways to get involved are to change your social media avatars to the official Vitamin D Day image, join the conversation on Twitter with the hashtag #VitaminDDay, and purchase vitamin D awareness bracelets to raise awareness and support further research and education
Please take the time and learn about vitamin D deficiency this November 2nd, and share what you know with others. Learn, educate and participate; let's get the word out!
"Isotonix Vitamin D with K2 may be the most cost effective supplement you can add to your regimen."
Key Ingredients Found in nutraMetrix Isotonix® Vitamin D with K2:
Vitamin D3 (Cholecalciferol) 5000 IU
Vitamin D is a fat-soluble vitamin that is found in some foods and endogenously produced when sunlight strikes the skin and activates vitamin D synthesis. Vitamin D promotes the efficient intestinal absorption of calcium, primarily in the duodenum and jejunum by supporting the synthesis of calcium-binding proteins to promote normal calcium absorption and retention. Vitamin D also promotes the normal formation of bone and normal bone growth and bone remodeling by osteoblasts and osteoclasts. Vitamin D deficiency can be caused by factors such as lack of exposure to sunlight, reduced skin synthesis of vitamin D, lower dietary intake, impaired intestinal absorption and reduced metabolism to active forms of vitamin D by the kidneys, all of which increase with aging. Deficiency has been linked to numerous health concerns, and insufficient levels of this vitamin are associated with weak bones and muscle weakness. In addition to promoting strong bones, vitamin D also has other roles in health, including supporting the body’s normal modulation of neuromuscular function and immune function. Vitamin D has been shown to support immune-modulation, and it is thought that supplementation promotes immune health by promoting the body’s normal regulation of T-cell function. In reference to cellular health, vitamin D supports the modulation of many genes that are responsible for encoding proteins that regulate normal cell cycle activity. Vitamin D levels have been strongly correlated to healthy cells. Lastly, through its interaction with VDR (vitamin D receptor), vitamin D supports the healthy expression of the gene encoding renin, thus helping to maintain healthy blood pressure.*
Vitamin K2 45 mcg
Vitamin K is a fat-soluble vitamin found in meat, eggs, dairy and natto. Although a fat-soluble vitamin, the body stores very little K2, and its stores are rapidly depleted without regular dietary intake. Natural vitamin K2, also known as menaquinone-7 (MK-7), is the most bioavailable form of K2 and has the longest half-life in the blood of any form of vitamin K. The Japanese soy food natto is particularly rich in menaquinone-7 (MK-7). Studies of natto consumption in Japan have linked menaquinone-7 to bone and cardiovascular health. The correlation of vitamin K to cardiovascular and bone health directly focuses on supporting proper calcium utilization, whereby adequate metabolism of calcium supports arterial and bone health. This is often referred to as the calcium paradox. The calcium paradox is explained simply as getting calcium in the right place (i.e., into the bone structures instead of the arterial vessel walls.) These events are dependent upon the synthesis of the vitamin K-dependent proteins osteocalcin and matrix Gla protein in a process called carboxylation. The carboxylation of these proteins is a post-translational step; that is, osteocalcin and matrix Gla protein are translated from their respective messenger RNA and then modified by enzymes to the active forms. These carboxylated forms support the healthy binding and releasing of calcium. This reaction is essential for optimal and healthy utilization of calcium. Vitamin K2 promotes the synthesis of proteins involved with calcium utilization, thereby supporting bone retention and arterial health. While Vitamin D supports the healthy regulation and synthesis of osteocalcin, the mineral-binding capacity of this protein requires vitamin K-dependent carboxylation and is thought to be related to bone mineralization. Gas6 is a vitamin K-dependent protein found throughout the nervous system, as well in the heart, lungs, stomach, kidneys and cartilage. Although the exact mechanism of its action has not been determined, Gas6 appears to be a cellular growth regulator involved in cellular activities such as cell adhesion, cell proliferation and protection against apoptosis.*
Learn More
Vitamin D Day, Saturday, Nov. 2, is a day to recognize vitamin D deficiency as a world problem. Researchers agree that at least one third of the world is deficient in vitamin D, and some scientists even think a greater percent of people are deficient in vitamin D. Why are so many people deficient, it's simple really, vitamin D from sun exposure. Now, more than ever, the world's population lives an indoor lifestyle, avoiding the sun daily.
Vitamin D awareness is particularly important this time of year because from around mid-October to mid-March the sun in Canada is not strong enough to stimulate natural vitamin D production. There are more than 100 good reasons to know your vitamin D level and take action to raise them to ideal levels. Most vitamin D experts recommend a vitamin D blood serum level between 100 and 150 nmol/L.
It's an exciting time for the vitamin D community. Doctors are beginning to discover that vitamin D deficiency is a risk factor for many diseases and may make some diseases more severe. They're also discovering that vitamin D can be an important piece in the treatment of some illnesses and diseases.
Supporting Vitamin D Day is easy. Just learn, education, and participate by checking out the website. Then, take a little time to educate your family and friends. Conquering world vitamin D deficiency starts with better awareness on how we get vitamin D and how we can make sure we're getting enough. Share a simple key fact from the link above, something your family and friends may not know about. The more people know, the more we can ensure people are getting enough vitamin D. And finally, participate. The easiest ways to get involved are to change your social media avatars to the official Vitamin D Day image, join the conversation on Twitter with the hashtag #VitaminDDay, and purchase vitamin D awareness bracelets to raise awareness and support further research and education
Please take the time and learn about vitamin D deficiency this November 2nd, and share what you know with others. Learn, educate and participate; let's get the word out!
"Isotonix Vitamin D with K2 may be the most cost effective supplement you can add to your regimen."
Primary Benefits of nutraMetrix Isotonix® Vitamin D with K2*:
- Promotes normal bone mineral density
- Promotes healthy arteries
- Supports immune health
- Helps maintain bone health
- Helps maintain bone mass by supporting normal osteoclast activity
- Helps maintain cardiovascular health
- Promotes elasticity of blood vessels
- Helps maintain normal blood pressure
- Women with low bone density have been found to be deficient in vitamin K
Key Ingredients Found in nutraMetrix Isotonix® Vitamin D with K2:
Vitamin D3 (Cholecalciferol) 5000 IU
Vitamin D is a fat-soluble vitamin that is found in some foods and endogenously produced when sunlight strikes the skin and activates vitamin D synthesis. Vitamin D promotes the efficient intestinal absorption of calcium, primarily in the duodenum and jejunum by supporting the synthesis of calcium-binding proteins to promote normal calcium absorption and retention. Vitamin D also promotes the normal formation of bone and normal bone growth and bone remodeling by osteoblasts and osteoclasts. Vitamin D deficiency can be caused by factors such as lack of exposure to sunlight, reduced skin synthesis of vitamin D, lower dietary intake, impaired intestinal absorption and reduced metabolism to active forms of vitamin D by the kidneys, all of which increase with aging. Deficiency has been linked to numerous health concerns, and insufficient levels of this vitamin are associated with weak bones and muscle weakness. In addition to promoting strong bones, vitamin D also has other roles in health, including supporting the body’s normal modulation of neuromuscular function and immune function. Vitamin D has been shown to support immune-modulation, and it is thought that supplementation promotes immune health by promoting the body’s normal regulation of T-cell function. In reference to cellular health, vitamin D supports the modulation of many genes that are responsible for encoding proteins that regulate normal cell cycle activity. Vitamin D levels have been strongly correlated to healthy cells. Lastly, through its interaction with VDR (vitamin D receptor), vitamin D supports the healthy expression of the gene encoding renin, thus helping to maintain healthy blood pressure.*
Vitamin K2 45 mcg
Vitamin K is a fat-soluble vitamin found in meat, eggs, dairy and natto. Although a fat-soluble vitamin, the body stores very little K2, and its stores are rapidly depleted without regular dietary intake. Natural vitamin K2, also known as menaquinone-7 (MK-7), is the most bioavailable form of K2 and has the longest half-life in the blood of any form of vitamin K. The Japanese soy food natto is particularly rich in menaquinone-7 (MK-7). Studies of natto consumption in Japan have linked menaquinone-7 to bone and cardiovascular health. The correlation of vitamin K to cardiovascular and bone health directly focuses on supporting proper calcium utilization, whereby adequate metabolism of calcium supports arterial and bone health. This is often referred to as the calcium paradox. The calcium paradox is explained simply as getting calcium in the right place (i.e., into the bone structures instead of the arterial vessel walls.) These events are dependent upon the synthesis of the vitamin K-dependent proteins osteocalcin and matrix Gla protein in a process called carboxylation. The carboxylation of these proteins is a post-translational step; that is, osteocalcin and matrix Gla protein are translated from their respective messenger RNA and then modified by enzymes to the active forms. These carboxylated forms support the healthy binding and releasing of calcium. This reaction is essential for optimal and healthy utilization of calcium. Vitamin K2 promotes the synthesis of proteins involved with calcium utilization, thereby supporting bone retention and arterial health. While Vitamin D supports the healthy regulation and synthesis of osteocalcin, the mineral-binding capacity of this protein requires vitamin K-dependent carboxylation and is thought to be related to bone mineralization. Gas6 is a vitamin K-dependent protein found throughout the nervous system, as well in the heart, lungs, stomach, kidneys and cartilage. Although the exact mechanism of its action has not been determined, Gas6 appears to be a cellular growth regulator involved in cellular activities such as cell adhesion, cell proliferation and protection against apoptosis.*
Learn More
Wednesday, June 12, 2013
Vitamin D Deficiency Can Trigger Hypertension
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| nutraMetrix Isotonix Vitamin D with K2 |
London: Findings of a large-scale genetic study suggest that vitamin D deficiency can trigger hypertension among people.
Researchers say the results of the D-CarDia collaboration -- world's largest study to examine the causal association between vitamin D and hypertension -- provide a strong case for food fortification with vitamin D in order to prevent some kinds of cardiovascular disease.
Although observational studies have already shown this link, a large-scale genetic study was necessary before the cause and effect could be proven.
The findings will be presented by Vimal Karani S. from the Institute of Child Health, University College London at the annual conference of the European Society of Human Genetics (ESHG) in Paris on Tuesday.
The research data, involving 35 studies, over 155,000 individuals, and numerous centres in Europe and North America, showed that those with high concentrations of 25-hydroxyvitamin D (25(OH)D) had reduced blood pressure and, therefore, a reduced risk of hypertension.
"We knew from earlier observational studies that low 25(OH)D concentrations were likely to be associated with increases in blood pressure and hypertension, but correlation is not causality," Vimal Karani says.
"Additionally, randomised controlled trials of vitamin D supplementation in humans have produced inconsistent effects on cardiovascular outcomes. The whole picture was somewhat confused, and we decided to try to figure it out once and for all," the researcher adds.
The researchers used genetic variants known as single nucleotide polymorphisms, or SNPs, as proxy markers to reflect individual's vitamin D status in order to test for a causal association with blood pressure and hypertension, reports a daily.
When the results were analysed, they found a significant link. For every 10 percent increase in 25(OH)D concentrations, there was a 8.1 percent decrease in the risk of developing hypertension.
Sunday, March 17, 2013
For Smokers, Low Levels of Vitamin D May Lead to Cancer
WASHINGTON, March 15, 2013 /PRNewswire/ -- New research appearing online today in Clinical Chemistry, the journal of AACC,
shows that decreased levels of vitamin D may predispose smokers to
developing tobacco-related cancer. This study illustrates that simple vitamin D blood tests and supplements have the potential to improve
smokers' health.
In
the U.S. alone, cigarette smoking accounts for more deaths annually
than HIV, illegal drugs, alcohol, motor vehicle injuries, suicides, and
murders combined. It is the primary causal factor for at least 30% of
all cancer deaths, and can lead to multiple kinds of cancer, including
bladder, cervical, esophageal, head and neck, kidney, liver, lung,
pancreatic, and stomach, as well as myeloid leukemia. According to the
Centers for Disease Control and Prevention, the healthcare expenditures
and productivity losses due to smoking cost the economy approximately $193 billion per year.
In
this paper, Afzal et al. measured plasma vitamin D levels in blood
samples collected in 1981–1983 from 10,000 Danes from the general
population. Researchers then followed the study participants for up to
28 years through the Danish Cancer Registry. Of the participants, 1,081
eventually developed a tobacco-related cancer. The authors determined
that the median vitamin D concentration among these participants was
only 14.8 ng/mL, versus the higher 16.4 ng/mL median concentration found
for all participants together.
These
results show for the first time that the risk of tobacco-related
cancers as a group is associated with lower concentrations of vitamin D.
The data also indicate that tobacco smoke chemicals may influence
vitamin D metabolism and function, while vitamin D may conversely modify
the carcinogenicity of tobacco smoke chemicals. If further research
confirms this, it would be consistent with previous studies
demonstrating the anti-tumorigenic effects of vitamin D derivatives, as
well as the correlation of vitamin D deficiency with favorable
cancer-forming conditions and increased susceptibility to tobacco smoke
carcinogens. Interestingly, though, low vitamin D levels were not
connected with risk of other cancer types.
"Our
analyses show that the association between lower concentrations of
plasma vitamin D and higher risk of cancer may be driven by
tobacco-related cancer as a group, which has not been shown before,"
stated author Borge G. Nordestgaard, MD, DMSc, in the paper. "This is
important for future studies investigating the association between
plasma vitamin D and risk of cancer."
About AACC
The American Association for Clinical Chemistry, AACC, brings together the global laboratory medicine community in the pursuit of improving health and healthcare through laboratory medicine. With more than 8,500 members including MDs, PhDs, research scientists, and others involved in developing tests and directing laboratory operations, AACC advances scientific collaboration, knowledge, expertise and innovation through its many programs, publications and initiatives. For more information, visit www.aacc.org
The American Association for Clinical Chemistry, AACC, brings together the global laboratory medicine community in the pursuit of improving health and healthcare through laboratory medicine. With more than 8,500 members including MDs, PhDs, research scientists, and others involved in developing tests and directing laboratory operations, AACC advances scientific collaboration, knowledge, expertise and innovation through its many programs, publications and initiatives. For more information, visit www.aacc.org
Clinical Chemistry
is the leading international journal of clinical laboratory science,
providing 2,000 pages per year of peer-reviewed papers that advance the
science of the field. With an impact factor of 7.9, Clinical Chemistry covers everything from molecular diagnostics to laboratory management.
****
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nutraMetrix Isotonix® Vitamin D with K2
Primary Benefits of nutraMetrix Isotonix® Vitamin D with K2*:
Key Ingredients Found in nutraMetrix Isotonix® Vitamin D with K2:
Vitamin D3 (Cholecalciferol) 5000 IU
Vitamin D is a fat-soluble vitamin that is found in some foods and endogenously produced when sunlight strikes the skin and activates vitamin D synthesis. Vitamin D promotes the efficient intestinal absorption of calcium, primarily in the duodenum and jejunum by supporting the synthesis of calcium-binding proteins to promote normal calcium absorption and retention. Vitamin D also promotes the normal formation of bone and normal bone growth and bone remodeling by osteoblasts and osteoclasts. Vitamin D deficiency can be caused by factors such as lack of exposure to sunlight, reduced skin synthesis of vitamin D, lower dietary intake, impaired intestinal absorption and reduced metabolism to active forms of vitamin D by the kidneys, all of which increase with aging. Deficiency has been linked to numerous health concerns, and insufficient levels of this vitamin are associated with weak bones and muscle weakness. In addition to promoting strong bones, vitamin D also has other roles in health, including supporting the body’s normal modulation of neuromuscular function and immune function. Vitamin D has been shown to support immune-modulation, and it is thought that supplementation promotes immune health by promoting the body’s normal regulation of T-cell function. In reference to cellular health, vitamin D supports the modulation of many genes that are responsible for encoding proteins that regulate normal cell cycle activity. Vitamin D levels have been strongly correlated to healthy cells. Lastly, through its interaction with VDR (vitamin D receptor), vitamin D supports the healthy expression of the gene encoding renin, thus helping to maintain healthy blood pressure.*
Vitamin K2 45 mcg
Vitamin K is a fat-soluble vitamin found in meat, eggs, dairy and natto. Although a fat-soluble vitamin, the body stores very little K2, and its stores are rapidly depleted without regular dietary intake. Natural vitamin K2, also known as menaquinone-7 (MK-7), is the most bioavailable form of K2 and has the longest half-life in the blood of any form of vitamin K. The Japanese soy food natto is particularly rich in menaquinone-7 (MK-7). Studies of natto consumption in Japan have linked menaquinone-7 to bone and cardiovascular health. The correlation of vitamin K to cardiovascular and bone health directly focuses on supporting proper calcium utilization, whereby adequate metabolism of calcium supports arterial and bone health. This is often referred to as the calcium paradox. The calcium paradox is explained simply as getting calcium in the right place (i.e., into the bone structures instead of the arterial vessel walls.) These events are dependent upon the synthesis of the vitamin K-dependent proteins osteocalcin and matrix Gla protein in a process called carboxylation. The carboxylation of these proteins is a post-translational step; that is, osteocalcin and matrix Gla protein are translated from their respective messenger RNA and then modified by enzymes to the active forms. These carboxylated forms support the healthy binding and releasing of calcium. This reaction is essential for optimal and healthy utilization of calcium. Vitamin K2 promotes the synthesis of proteins involved with calcium utilization, thereby supporting bone retention and arterial health. While Vitamin D supports the healthy regulation and synthesis of osteocalcin, the mineral-binding capacity of this protein requires vitamin K-dependent carboxylation and is thought to be related to bone mineralization. Gas6 is a vitamin K-dependent protein found throughout the nervous system, as well in the heart, lungs, stomach, kidneys and cartilage. Although the exact mechanism of its action has not been determined, Gas6 appears to be a cellular growth regulator involved in cellular activities such as cell adhesion, cell proliferation and protection against apoptosis.*
Scientific Studies Which Support nutraMetrix Isotonix® Vitamin D with K2:
· Knapen
M et al. Vitamin K2 supplementation improves hip bone geometry and bone
strength indices in postmenopausal women. Osteoporosis International.
18(7):963-72, 2007.
· Shiraki,
M., et al. Vitamin K2 (menatetrenone) effectively prevents fractures
and sustains lumbar bone mineral density in osteoporosis. Journal of
Bone & Mineral Research. 15:515-522, 2000.
· Hiruma
Y et al. Vitamin K(2) and geranylgeraniol, its side chain component,
inhibited osteoclast formation in a different manner. Biochemical
Biophysical Research Communications. 314(1):24-30, 2004.
· Plaza S and Lamson D. Vitamin K2 in bone metabolism and osteoporosis. Alternative Medicine Reviews. 10(1):24-35, 2005. Review.
· Kameda
T et al. Vitamin K2 inhibits osteoclastic bone resorption by inducing
osteoclast apoptosis. Biochemical and Biophysical Research
Communications. 220(3):515-519, 1996.
· Taira
H et al. Menatetrenone (vitamin K2) acts directly on circulating human
osteoclast precursors. Calcified Tissue International. 73(1):78-85,
2003.
Hidaka T et al. Treatment for patients with postmenopausal osteoporosis who have been placed on HRT and show a decrease in bone mineral density: effects of concomitant administration of vitamin K(2). Journal of Bone and Mineral Metabolism. 20(4):235-239, 2002.
· Iwamoto J et al. Effects of vitamin K2 on osteoporosis. Current Pharmaceutical Design. 10(21):2557-2576, 2004.
· Iwamoto
J et al. Treatment with vitamin D3 and/or vitamin K2 for postmenopausal
osteoporosis. The Keio Journal of Medicine. 2003 Sep;52(3):147-50.
Review.
· Neogi,
T., et al. Low vitamin K status is associated with osteoarthritis in
the hand and knee. Arthritis and Rheumatism. 54(4):1255-1261, 2006.
Price P. Role of vitamin K-dependent proteins in bone metabolism. Annual Review of Nutrition. 8:565-583, 1988.
· Bekner K. The vitamin K-dependent carboxylase. Journal of Nutrition. 130(8):1877-1880, 2000.
· Nelsestuen G et al. Vitamin K-dependent proteins. Vitamins and Hormones. 58:355-389, 2000.
· Shearer
M. Role of vitamin K and Gla proteins in the pathophysiology of
osteoporosis and vascular calcification. Current Opinion in Clinical
Nutrition and Metabolic Care. 3(6):433-438, 2000.
· Gundberg
C et al. Vitamin K status and bone health: an analysis of methods for
determination under carboxylated osteocalcin. Journal of Clinical
Endocrinology and Metabolism. 83(9):3258-3266, 1998.
· Weber
P. Management of osteoporosis: is there a role for vitamin K?
International Journal for Vitamin and Nutrition Research. 67(5):350-6,
1997.
· Garber,
A. K., et al. Comparison of phylloquinone bioavailability from food
sources or a supplement in human subjects. Journal of Nutrition.
129(6):1201-1203, 1999.
· Binkley N et al. Vitamin K nutrition and osteoporosis. Journal of Nutrition. 125(7):1812-1821, 1995.
· Bischoff-Ferrari
Het al. Fracture prevention with vitamin D supplementation: a
meta-analysis of randomized controlled trials. JAMA.
293(18):2257-2264, 2005.
· Guirguis-Blake
J et al. Oral vitamin D3 decreases fracture risk in the elderly.
Journal of Family Practice. 52(6):431-435, 2003.
· Schaafsma,
A., et al. Vitamin D3 and vitamin K1 supplementation of Dutch
postmenopausal women with normal and low bone mineral densities:
effects on serum 25-hydroxyvitamin D and carboxylated osteocalcin.
European Journal of Clinical Nutrition. 54:626-631, 2000.
· Trivedi
Det al. Effect of four monthly oral vitamin D3 (cholecalciferol)
supplementation on fractures and mortality in men and women living in
the community: randomised double blind controlled trial. British
Medical Journal. 326(7387):469, 2003.
· Van
den Berghe G et al. Bone turnover in prolonged critical illness:
effect of vitamin D. Journal of Clinical Endocrinology and Metabolism.
88(10):4623-4632, 2003.
· Chapuy M et al. Vitamin D3 and calcium to prevent hip fractures in the elderly women. New England Journal of Medicine. 327(23):1637-1642, 1992.
· Grant W and Holick M. Benefits and requirements of vitamin D for optimal health. Alternative Medicine Review. 10:94-111, 2005.
· Plaza S and Lamson D. Vitamin K2 in bone metabolism and osteoporosis. Alternative Medicine Reviews. 10(1):24-35, 2005. Review.
· Zitterman
A et al. Low vitamin D status: a contributing factor in the
pathogenesis of congestive heart failure? Journal of the American College of Cardiology. 41(1):105-112, 2003.
· Schleithoff
S et al. Vitamin D supplementation improves cytokine profiles in
patients with congestive heart failure: a double-blind, randomized,
placebo-controlled trial. American Journal of Clinical Nutrition.
83(4):754-759, 2006.
Argiles A et al. Blood pressure is correlated with vitamin D(3) serum levels in dialysis patients. Blood Purification. 20(4):370-375, 2002.
· Kristal-Boneh E et al. Association of calcitriol and blood pressure in normotensive men. Hypertension. 30(5):1289-1294, 1997.
· Li
Y et al. 1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator
of the renin-angiotensin system. Journal of Clinical Investigation.
110(2):229-238, 2002.
· Li Y et al. Vitamin D regulation of the renin-angiotensin system. Journal of Cell Biochemistry. 88(2):327-331, 2003.
· Li
Y et al. Vitamin D: a negative endocrine regulator of the
renin-angiotensin system and blood pressure. Journal of Steroid
Biochemistry and Molecular Biology. 89-90(1-5):387-392, 2004.
· Pfeifer
M et al. Effects of a short-term vitamin D(3) and calcium
supplementation on blood pressure and parathyroid hormone levels in
elderly women. Journal of Clinical Endocrinology and Metabolism.
86(4):1633-1637, 2001.
· Sigmund
C. Regulation of renin expression and blood pressure by vitamin D(3).
Journal of Clinical Investigation. 110(2):155-156, 2002.
Vasquez A et al. The clinical importance of vitamin D (cholecalciferol): a paradigm shift with implications for all healthcare providers. Alternative Therapies. 10(5):28-38, 2004.
· Nimptsch K et al. Dietary intake of vitamin K and risk of prostate cancer in the Heidelberg
cohort of the European Prospective Investigation into Cancer and
Nutrition. American Journal of Clinical Nutrition. 87:985-992, 2008.
· Habu
D et al. Role of vitamin K2 in the development of hepatocellular
carcinoma in women with viral cirrhosis of the liver. JAMA.
292(3):358-361, 2004.
· Yoshida
T et al. Apoptosis induction of vitamin K2 in lung carcinoma cell
lines: the possibility of vitamin K2 therapy for lung cancer.
International Journal of Oncology. 23(3):627-632, 2003.
· Lamson D and Plaza S. The anticancer effects of vitamin K. Alternative Medicine Review. 8(3):303-18, 2003.
Yokoyama T et al. Combination of vitamin K2 plus imatinib mesylate enhances induction of apoptosis in small cell lung cancer cell lines. International Journal of Oncology. 26(1):33-40, 2005.
· Chlebowski R et al. Vitamin K in the treatment of cancer. Cancer Treatment Review. 12:49-63, 1985.
· Lamson D et al. The anticancer effects of vitamin K. Alternative Medicine Review. 8(3):303-318, 2003.
· Hitomi M et al. Antitumor effects of vitamins K1, K2 and K3 on hepatocellular carcinoma in vitro and in vivo. International Journal of Oncology. 26(3):713-720, 2005.
· Nouso
K et al. Regression of hepatocellular carcinoma during vitamin K
administration. World Journal of Gastroenterology. 11(42):6722-6724,
2005.
· Blackmore
K et al. Vitamin D from dietary intake and sunlight exposure and the
risk of hormone-receptor-defined breast cancer. American Journal of
Epidemiology. 168(8):915-24, 2008.
· Deluca H et al. Vitamin D: its role and uses in immunology. FASEB Journal. 15(14):2579-2585, 2001.
Adorini L. Immunomodulatory effects of vitamin D receptor ligands in autoimmune diseases. International Immunopharmacology. 2(7):1017-1028, 2002.
· Cantorna
M et al. Mounting evidence for vitamin D as an environmental factor
affecting autoimmune disease prevalence. Experimental Biology and
Medicine (Maywood). 229(11):1136-1142, 2004.
· Cantorna
M. Vitamin D and autoimmunity: is vitamin D status an environmental
factor affecting autoimmune disease prevalence? Society for Experimental
Biology and Medicine. 223:230-233, 2000.
· Garland C et al. The role of vitamin D in cancer prevention. American Journal of Public Health. 96(2):252-61, 2006.
· Giovannucci
E et al. Prospective study of predictors of vitamin D status and
cancer incidence and mortality in men. Journal of the National Cancer
Institute. 98(7):451-459, 2006.
· Holick,
M. Vitamin D: Its role in cancer prevention and treatment. Progress
in Biophysics and Molecular Biology. 92(1):49-59, 2006.
· Gorham
E et al. Vitamin D and prevention of colorectal cancer. Journal
Steroid Biochemistry and Molecular Biology. 97(1-2):179-94, 2005.
· Grant
W et al. Reviews: A critical review of studies on vitamin D in
relation to colorectal cancer. Nutrition and Cancer. 48(2):115-123,
2004.
· Harris D et al. Vitamin D and colon carcinogenesis. Journal of Nutrition. 134(12):3463S-3471S, 2004.
· Hayes
C et al. The immunological functions of the vitamin D endocrine
system. Cellular and Molecular Biology. 49(2):277-300, 2003.
What Makes nutraMetrix Isotonix® Vitamin D with K2 Unique?
nutraMetrix
Isotonix Vitamin D with K2 contains vitamin D3, the metabolically
active form of vitamin D, along with vitamin K2, a form of vitamin K
which supports vascular health and calcium utilization. Vitamin D plays
an important role in bone health, heart health and immune support, while
working with vitamin K to support normal absorption of calcium and
promote healthy arteries. nutraMetrix Isotonix Vitamin D is the first of
its kind to deliver both of these powerful vitamins with isotonic
delivery.
Vitamin
K is included in nutraMetrix Isotonix Vitamin D with K2 because of its
unique partnership with vitamin D. Vitamins K and D work together to
support calcium absorption and utilization. Vitamin K supports the
normal delivery of calcium to the bones and promotes healthy arteries.
At
least two naturally-occurring forms of vitamin K have been identified
and are known as K1 and K2. While there are many similarities between
these two forms of vitamin K, they are distinguished by their important
differences. The most significant difference between K1 and K2 is their
chemical structure which results in different pharmacokinetic
properties. Vitamin K1 is retained primarily in the liver where, at high
doses, it may interfere with the action of warfarin and other
anticoagulant medications.
Vitamin
K2 has a different mechanism of action. It is transported primarily to
bones and blood vessels. Vitamin K2 helps to maintain bone mass, support
calcium utilization and promote elasticity of blood vessels.
Some
studies have concluded that vitamin K2 does not interfere with
anticoagulant medications.* However, most products containing vitamin K
(including K1 and/or K2) warn users taking anticoagulants not to take
the product. If you are currently taking warfarin or another
anticoagulant medication, you should consult your physician before
taking any product containing vitamin K1 or K2.
Isotonix
dietary supplements are delivered in an isotonic solution. This means
that the body has less work to do to obtain maximum absorption of the
nutrients. The isotonic state of the suspension allows nutrients to pass
directly into the small intestine and rapidly absorb into the
bloodstream. With Isotonix products, little nutritive value is lost,
making the absorption of nutrients highly efficient while delivering
maximum results.
Related terms: vitamin D, vitamin K, bone health, cardiovascular health, immune support, D3, K2
Frequently Asked Questions about nutraMetrix Isotonix® Vitamin D with K2:
Why is vitamin K included in nutraMetrix Isotonix Vitamin D with K2?
Vitamin K is included in this product because of its unique partnership with vitamin D. Vitamins K and D work together to promote healthy calcium absorption and utilization. Vitamin K supports the delivery of calcium to the bones and helps maintain arterial health.*
Is nutraMetrix Isotonix Vitamin D with K2 safe for people on anticoagulant medications?Some
studies have concluded that vitamin K2 does not interfere with
anticoagulant medications. However, most products containing vitamin K
(including K1 and/or K2) warn users taking anticoagulants not to take
the product. If you are currently taking warfarin or another
anticoagulant medication, you should consult your physician before
taking any product containing vitamin K1 or K2.
How do I take nutraMetrix Isotonix Vitamin D with K2?
Mix one capful of Isotonix Vitamin D with K2 with 2 ounces of water. Take one serving daily.
Is it safe to take more than 1 serving of this product daily?
One serving daily of Isotonix Vitamin D with K2 is recommended. Check with your physician before taking additional daily servings of this product.
Is there a toxicity level for vitamin D?
The recommended daily Upper Limit for vitamin D is 10,000 IU, however, safety studies indicate that up to 40,000 IU may be safe for most people. If you wish to take more than one daily serving of this product, you should check with your physician.
What are dietary sources of vitamin D?
Foods rich in vitamin D include cod liver oil, salmon, mackerel and tuna.
* These statements have not been evaluated by the Food and Drug Administration.
This product(s) is not intended to diagnose, treat, cure or prevent any disease.
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Enterprises, Inc. specializes in helping individuals, groups, & companies
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