MS and Vitamin D Study- A follow-up

This is a follow-up to my earlier exciting post about the Vitamin D study taking place to determine if vitamin D can PREVENT multiple sclerosis. This article comes from ABC News Australia. Stay tuned.

MS study into link with Vitamin D

Nance Haxton reported this story on Tuesday, October 16, 2012 08:16:00

Listen to MP3 of this story ( minutes)

TONY EASTLEY: Multiple Sclerosis is a condition that still holds many mysteries. Its symptoms vary widely between sufferers and the cause of the condition is still unknown.

Researchers involved in what they say is a world first study hope to prove that a lack of vitamin D plays a key role.

The clinical trial will focus on those people newly diagnosed with MS to see if doses of Vitamin D stall or prevent its development.

Nance Haxton reports.

NANCE HAXTON: One of the most puzzling aspects of multiple sclerosis is that people who live in Tasmania are 10 times more likely to develop the condition than their counterparts in Darwin.

Sharlene Brown is one Tasmanian who hopes that this study will make sense of how she developed the disease.

SHARLENE BROWN: Oh chronic fatigue, pins and needles, the numbness from the waist down. I couldn't feel my legs but I was actually walking so it was a really bizarre symptom. Heat intolerance, eyesight going blurry in the heat.

And of course over time I have historically thought about what I used to do. I'm a bit of a bookworm, I must say I spend a lot of time inside. I often wonder whether if I'd spent more time out in the playground instead of the library, whether that would have made a difference.

NANCE HAXTON: It's long been suspected that Vitamin D, or a lack thereof, has a large part to play in the development of multiple sclerosis.

Menzies Research Institute professor Bruce Taylor says this placebo controlled trial will hopefully give scientific proof to that hypothesis.

BRUCE TAYLOR: We know that MS is not evenly distributed around the world. The further you get away from the equator in a genetically susceptible population, the great your risk of getting MS. That means about 90 per cent of your risk of getting MS can be due to your environment.

And we think, and our science all points to this, that vitamin D, derived from solar radiation, may be one of the clues.

NANCE HAXTON: Because there's still a lot of mystery surrounding MS isn't there, just even the varying symptoms that different people have?

BRUCE TAYLOR: Oh yeah well MS is one of the most difficult diseases to study. And that's why it's unfortunately been very badly studied in the past, because it has a huge what we call interpersonal and intrapersonal variation.

So one can have very bad MS for a period of time and then they can just stop having attacks.

We spent a lot of time designing the study to (inaudible) which means that if there is a significant effect of MS, we will be able to pick this is up in this study.

And this is unique - no-one else in the world is doing this. This is an Australian and New Zealand first and this is really a major scientific step forward for MS.

NANCE HAXTON: The chief executive of MS Research Australia Jeremy Wright says this study launched today at Royal Hobart Hospital has provided new hope to those battling multiple sclerosis.

JEREMY WRIGHT: We know a lot about the, if you like, the circumstantial evidence that links vitamin D deficiency and MS and we want to take that fact and act on it and see if vitamin D at the earliest stage of MS can really effect the progress of the disease, slow it or stop it.

NANCE HAXTON: Sharlene Brown celebrated her 40th birthday on the weekend. But despite being in remission from MS for more than nine years, her future health remains uncertain.

She hopes the results of this study will prevent a similar outcome for people yet to develop the condition.

SHARLENE BROWN: If you can help prevent future generations suffering from this type of illness and it can be done as simply as monitoring your vitamin D levels then that's really exciting I think for people who have it or for those people who think they might actually be in the early stages of it.

And I think that's the exciting part of the study. It could be something so simple.

TONY EASTLEY: MS sufferer Sharlene Brown ending Nance Haxton's report. 

*****

Commentary:

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New trial will test if Vitamin D can prevent MS

Courtesy HealthCanal.com (10/17/12)

World first clinical trial
One of the most important developments in the prevention of multiple sclerosis (MS) is a world first clinical trial set to take place in Australia and New Zealand.  It will test whether Vitamin D can prevent MS in those at risk of developing the disease.

Tasmania, with the highest incidence of MS in Australia, will play a key role in the trial. The PrevANZ study was launched recently in Hobart by Hon Julie Collins, the Federal Minister for Community Services, the Status of Women and Indigenous Employment and Economic Development.

The trial will focus on the possibility of using vitamin D supplementation to prevent a diagnosis of MS following a person’s presentation with the first symptoms that may lead to a diagnosis of MS.  It will also test appropriate dosage levels and safety; information that may eventually lead to an effective prevention strategy for MS.

Multiple Sclerosis is an inflammatory disease that affects the brain and spinal cord. Though the causes of the disease are unknown, a deficiency of Vitamin D (which is primarily synthesized in the skin by exposure to UV light) is now thought to play a major role in some patients. Three out of four people with MS are women who are usually diagnosed in their 20s and 30s.

Australian researchers, including Prof Bruce Taylor, of the Menzies Research Institute Tasmania and the Royal Hobart Hospital, have been pivotal in establishing the link between Vitamin D deficiency and MS.

“I’m very pleased to be launching this groundbreaking international clinical trial here in Tasmania,” Minister Collins said.

“It is great that Tasmanian patients will not only contribute to this research, but could also be among the first to benefit from its results.

“I want to congratulate MS Research Australia on their outstanding work and wish them the very best of luck with this very important trial.

This vitamin D MS prevention trial, known as PrevANZ, is being funded by MS Research Australia (MSRA), through the support of Australian state-based MS societies, especially from Western Australia, Queensland and Tasmania.

“This is a gold-standard, placebo controlled trial,” said Professor Bruce Taylor, Menzies Research Institute Tasmania and member of the PrevANZ steering committee.
“This is the first trial of its kind in the world, to see whether oral Vitamin D supplementation can benefit people who may be in the earliest stages of MS – Australia has a very real opportunity here to help reduce the impact of MS around the world .”

While $2.5 million has been secured to commence the trial, and significant funding has been provided by the Royal Hobart Hospital Research Foundation in its appointment of Prof Taylor as a Research Fellow, a further $1 million is needed to extend the sample size and achieve a robust and conclusive answer.  Trial subjects will be recruited solely through neurologists.  People already diagnosed with MS who are concerned about their vitamin D status should discuss this with their GP or neurologist.

*****

Commentary

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What Makes nutraMetrix Isotonix® Vitamin D with K2 Unique?
nutraMetrix Isotonix Vitamin D with K2 contains vitamin D3, the metabolically active form of vitamin D, along with vitamin K2, a form of vitamin K which supports vascular health and calcium utilization. Vitamin D plays an important role in bone health, heart health and immune support, while working with vitamin K to support normal absorption of calcium and promote healthy arteries. nutraMetrix Isotonix Vitamin D is the first of its kind to deliver both of these powerful vitamins with isotonic delivery.
Vitamin K is included in nutraMetrix Isotonix Vitamin D with K2 because of its unique partnership with vitamin D. Vitamins K and D work together to support calcium absorption and utilization. Vitamin K supports the normal delivery of calcium to the bones and promotes healthy arteries.
At least two naturally-occurring forms of vitamin K have been identified and are known as K1 and K2. While there are many similarities between these two forms of vitamin K, they are distinguished by their important differences. The most significant difference between K1 and K2 is their chemical structure which results in different pharmacokinetic properties. Vitamin K1 is retained primarily in the liver where, at high doses, it may interfere with the action of warfarin and other anticoagulant medications. 
Vitamin K2 has a different mechanism of action. It is transported primarily to bones and blood vessels. Vitamin K2 helps to maintain bone mass, support calcium utilization and promote elasticity of blood vessels.  
Some studies have concluded that vitamin K2 does not interfere with anticoagulant medications.* However, most products containing vitamin K (including K1 and/or K2) warn users taking anticoagulants not to take the product. If you are currently taking warfarin or another anticoagulant medication, you should consult your physician before taking any product containing vitamin K1 or K2.
Isotonix dietary supplements are delivered in an isotonic solution. This means that the body has less work to do to obtain maximum absorption of the nutrients. The isotonic state of the suspension allows nutrients to pass directly into the small intestine and rapidly absorb into the bloodstream. With Isotonix products, little nutritive value is lost, making the absorption of nutrients highly efficient while delivering maximum results.
Related terms: vitamin D, vitamin K, bone health, cardiovascular health, immune support, D3, K2


Frequently Asked Questions about nutraMetrix Isotonix® Vitamin D with K2:
Why is vitamin K included in nutraMetrix Isotonix Vitamin D with K2?
Vitamin K is included in this product because of its unique partnership with vitamin D. Vitamins K and D work together to promote healthy calcium absorption and utilization. Vitamin K supports the delivery of calcium to the bones and helps maintain arterial health.* 
Is nutraMetrix Isotonix Vitamin D with K2 safe for people on anticoagulant medications?Some studies have concluded that vitamin K2 does not interfere with anticoagulant medications. However, most products containing vitamin K (including K1 and/or K2) warn users taking anticoagulants not to take the product. If you are currently taking warfarin or another anticoagulant medication, you should consult your physician before taking any product containing vitamin K1 or K2.
How do I take nutraMetrix Isotonix Vitamin D with K2?
Mix one capful of Isotonix Vitamin D with K2 with 2 ounces of water. Take one serving daily.
Is it safe to take more than 1 serving of this product daily?
One serving daily of Isotonix Vitamin D with K2 is recommended. Check with your physician before taking additional daily servings of this product.
Is there a toxicity level for vitamin D?
The recommended daily Upper Limit for vitamin D is 10,000 IU, however, safety studies indicate that up to 40,000 IU may be safe for most people. If you wish to take more than one daily serving of this product, you should check with your physician.
What are dietary sources of vitamin D?
Foods rich in vitamin D include cod liver oil, salmon, mackerel and tuna.

* These statements have not been evaluated by the Food and Drug Administration.
This product(s) is not intended to diagnose, treat, cure or prevent any disease.

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