Resveratrol with radiation kills more tumors

Story Courtesy of Christian Basi, BasiC@missouri.edu

Resveratrol, a compound found commonly in grape skins and red wine, has been shown to have several beneficial effects on human health, including cardiovascular health and stroke prevention. Now, a University of Missouri researcher has discovered that the compound can make prostate tumor cells more susceptible to radiation treatment, increasing the chances of a full recovery from all types of prostate cancer, including aggressive tumors.



“Other studies have noted that resveratrol made tumor cells more susceptible to chemotherapy, and we wanted to see if it had the same effect for radiation therapy,” said Michael Nicholl, an assistant professor of surgical oncology in the MU School of Medicine. “We found that when exposed to the compound, the tumor cells were more susceptible to radiation treatment, but that the effect was greater than just treating with both compounds separately.”

Prostate tumor cells contain very low levels of two proteins, perforin and granzyme B, which can function together to kill cells. However, both proteins need to be highly “expressed” to kill tumor cells. In his study, when Nicholl introduced resveratrol into the prostate tumor cells, the activity of the two proteins increased greatly. Following radiation treatment, Nicholl found that up to 97 percent of the tumor cells died, which is a much higher percentage than treatment with radiation alone.

“It is critical that both proteins, perforin and granzyme B, are present in order to kill the tumor cells, and we found that the resveratrol helped to increase their activity in prostate tumor cells,” Nicholl said. “Following the resveratrol-radiation treatment, we realized that we were able to kill many more tumor cells when compared with treating the tumor with radiation alone. It’s important to note that this killed all types of prostate tumor cells, including aggressive tumor cells.”

Resveratrol is present in grape skins and red wine and available over-the-counter in many health food sections at grocery stores. However, the dosage needed to have an effect on tumor cells is so great that many people would experience uncomfortable side effects.

“We don’t need a large dose at the site of the tumor, but the body processes this compound so efficiently that a person needs to ingest a lot of resveratrol to make sure enough of it ends up at the tumor site. Because of that challenge, we have to look at different delivery methods for this compound to be effective,” Nicholl said. “It’s very attractive as a therapeutic agent since it is a natural compound and something that most of us have consumed in our lifetimes.”

Nicholl said that the next step would be to test the procedure in an animal model before any clinical trials can be initiated. Nicholl’s studies were published in the Journal of Andrology and Cancer Science. The early-stage results of this research are promising. If additional studies, including animal studies, are successful within the next few years, MU officials will request authority from the federal government to begin human drug development (this is commonly referred to as the “investigative new drug” status). After this status has been granted, researchers may conduct human clinical trials with the hope of developing new treatments for cancer.

nutraMetrix Isotonix® Resveratrol

Isotonix Resveratrol is an isotonic-capable supplement made from three patented ingredients: Resveravine with 20% resveratrol extract, BioVin® Advanced with 5% resveratrol extract, and VitaBlue® (wild blueberry extract), designed to promote normal cell health. Isotonix Resveratrol works to maintain cell health, promote normal cell cycle activity, promote apoptosis (programmed cell death) in unhealthy cells, support the normal activity of the SIRT-1 gene, and promote cardiovascular health by promoting healthy platelet activity, promoting vasorelaxation, and providing antioxidant protection of LDL particles. Resveravine is a combination of trans-resveratrol (20% purity) and viniferin extracted from vine stems, which work synergistically to enhance the effectiveness of resveratrol extract. Trans-resveratrol is the predominate isomer found in red wine grapes and juice, and Resveravine is 100 to 300 times more concentrated in trans-resveratrol than other products from grape skin. According to the Linus Pauling Institute at Oregon State University, trans-resveratrol may have a higher bioavailability than other isomers of resveratrol. Resveravine provides a higher level of free radical defense against oxidative stress, stronger promotion of normal cellular activity and higher antioxidant protection of LDL particles than pure resveratrol extract.

Isotonic, which means “same pressure,” bears the same chemical resemblance of the body’s blood, plasma and tears. All fluids in the body have a certain concentration, referred to as osmotic pressure. The body’s common osmotic pressure, which is isotonic, allows a consistent maintenance of body tissues. In order for a substance to be absorbed and used in the body’s metabolism, it must be in an isotonic state. 

Isotonic dietary supplements are delivered in an isotonic solution. This means that the body has less work to do to obtain maximum absorption of the nutrients. The isotonic state of the suspension allows nutrients to pass directly into the small intestine and rapidly absorb into the bloodstream. With Isotonic capable products, little nutritive value is lost, making the absorption of nutrients highly efficient while delivering maximum results.

Buy nutraMetrix Isotonix® Resveratrol

 

Orlampa Enterprises, Inc. specializes in helping individuals lose sickness and find wellness.  

Orlampa Enterprises also helps health care professionals implement holistic wellness programs into their existing practice with the goal to educate both the health care provider and the patient. The programs, which provide the health care professional with a substantial additional income stream in this ever changing medical marketplace, allow the patient to achieve true wellness instead of receiving a traditional treatment for symptoms.

Orlampa Enterprises is an internet based product broker specializing in personalized health and wellness related services. Orlampa Enterprises is primed to continue its growth by duplicating its successful business model of educating, training, and developing entrepreneurial leaders as business partners. As an Unfranchise™ business owner, Orlampa Enterprises, proudly utilizes highly researched products including nutraMetrix® nutritional supplements. 

 Orlampa Enterprises' motto is "Eat well, exercise, and supplement intelligently."

Contact Beth at bb@orlampa.com or 

727.492.8212 

for more information about nutraMetrix® partnership opportunities available.

 

* These statements have not been evaluated by the Food and Drug Administration.
This product(s) is not intended to diagnose, treat, cure or prevent any disease.